Viser treff 214-233 av 358

    • Mucoadhesive liposomal delivery systems : the choice of coating material 

      Karn, Pankaj Ranjan; Vanic, Zeljka; Pepic, Ivan; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Development of liposomal mucoadhesive drug delivery system, which is able to improve the bioavailability of poorly absorbed oral drugs by prolonging their gastric and intestinal residence time, through facilitating the intimate contact of the delivery system with the absorption membrane. Liposomes containing model drug atenolol were prepared by the modified ethanol injection method. Liposomes ...
    • Mucoadhesive liposomes as new formulation for vaginal delivery of curcumin 

      Berginc, Katja; Suljakovic, Sabina; Skalko-Basnet, Natasa; Kristl, Albin (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
    • Mucosal Metabolomic Profiling and Pathway Analysis Reveal the Metabolic Signature of Ulcerative Colitis 

      Diab, Joseph; Hansen, Terkel; Goll, Rasmus; Stenlund, Hans; Jensen, Einar; Moritz, Thomas; Florholmen, Jon; Forsdahl, Guro (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-27)
      The onset of ulcerative colitis (UC) is characterized by a dysregulated mucosal immune response triggered by several genetic and environmental factors in the context of host–microbe interaction. This complexity makes UC ideal for metabolomic studies to unravel the disease pathobiology and to improve the patient stratification strategies. This study aims to explore the mucosal metabolomic profile in ...
    • Mucus-PVPA (mucus Phospholipid Vesicle-based Permeation Assay): An artificial permeability tool for drug screening and formulation development 

      Falavigna, Margherita; Klitgaard, Mette; Brase, Christina; Ternullo, Selenia; Skalko-Basnet, Natasa; Flaten, Gøril Eide (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-26)
      The mucus layer covering all mucosal surfaces in our body is the first barrier encountered by drugs before their potential absorption through epithelial tissues, and could thus affect the drugs’ permeability and their effectiveness. Therefore, it is of key importance to have in vitro permeability models that can mimic this specific environment. For this purpose, the novel mucus phospholipid vesicle-based ...
    • Multi-scale modeling of drug binding kinetics to predict drug efficacy 

      Clarelli, Fabrizio; Liang, Jingyi; Martinecz, Antal; Heiland, Ines; Wiesch, Pia Abel Zur (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-25)
      Optimizing drug therapies for any disease requires a solid understanding of pharmacokinetics (the drug concentration at a given time point in different body compartments) and pharmacodynamics (the effect a drug has at a given concentration). Mathematical models are frequently used to infer drug concentrations over time based on infrequent sampling and/or in inaccessible body compartments. Models are ...
    • Multi-scale modeling of drug binding kinetics to predict drug efficacy 

      Clarelli, Fabrizio; Liang, Jingyi; Martinecz, Antal; Heiland, Ines; Abel zur Wiesch, Pia (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-25)
      Optimizing drug therapies for any disease requires a solid understanding of pharmacokinetics (the drug concentration at a given time point in different body compartments) and pharmacodynamics (the effect a drug has at a given concentration). Mathematical models are frequently used to infer drug concentrations over time based on infrequent sampling and/or in inaccessible body compartments. Models are ...
    • Multifunctional Nanofibrous Dressing with Antimicrobial and Anti-Inflammatory Properties Prepared by Needle-Free Electrospinning 

      Schulte Werning, Laura; Murugaiah, Anjanah; Singh, Bhupender; Johannessen, Mona; Engstad, Rolf Einar; Skalko-Basnet, Natasa; Holsæter, Ann Mari (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-21)
      An active wound dressing should address the main goals in wound treatment, which are improved wound healing and reduced infection rates. We developed novel multifunctional nanofibrous wound dressings with three active ingredients: chloramphenicol (CAM), beta-glucan (βG) and chitosan (CHI), of which βG and CHI are active nanofiber-forming biopolymers isolated from the cell walls of Saccharomyces ...
    • Nanomedicines for the topical treatment of vulvovaginal infections: Addressing the challenges of antimicrobial resistance 

      Vanic, Zeljka; Jøraholmen, May Wenche; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-30)
      Recent years have, surprisingly, witnessed an increase in incidence of sexually transmitted infections (STIs). At the same time, antimicrobial therapy came under the threat of ever rising antimicrobial resistance (AMR), resulting in STIs with extremely limited therapy options. In this review, we addressed the challenges of treating vaginal infections in an era of AMR. We focused on published work ...
    • Nanopharmaceuticals for improved topical vaginal delivery: Can they deliver? 

      Vanic, Zeljka; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Nanopharmaceuticals have the potential to revolutionise medical treatment by permitting the design of more potent, less toxic “smart” therapeutics, ultimately leading to personalised medicine. This review summarises the challenges and potential uses of nanodelivery system for the topical drug therapy of vaginal diseases. The vaginal route of drug administration remains a challenge in the development ...
    • Natural Transformation Facilitates Transfer of Transposons, Integrons and Gene Cassettes between Bacterial Species 

      Domingues, Sara; Harms, Klaus; Fricke, W. Florian; Johnsen, Pål Jarle; da Silva, Gabriela J.; Nielsen, Kåre M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      We have investigated to what extent natural transformation acting on free DNA substrates can facilitate transfer of mobile elements including transposons, integrons and/or gene cassettes between bacterial species. Naturally transformable cells of Acinetobacter baylyi were exposed to DNA from integron-carrying strains of the genera Acinetobacter, Citrobacter, Enterobacter, Escherichia, Pseudomonas, ...
    • A new preparation method for preparation of liposomes-in-hydrogels primed for treatment of skin diseases 

      Ingebrigtsen, Sveinung Gaarden; Johansen, Kurt Jonny; Skalko-Basnet, Natasa; Holsæter, Ann Mari (Conference object; Konferansebidrag, 2014)
      <p>Liposomes are spherical vesicles that form spontaneously when phospholipids are dispersed in an aqueous medium. However, to get liposomes with a more unimodal size distribution, liposomes are usually processed further to reduced size and lammellarity, typically by extrusion, sonication or homogenization. <p>Liposome formulations for topical application needs a vehicle to assure the desirable ...
    • No change in the consumption of thyroid hormones after starting low dose naltrexone (LDN): A quasi-experimental before-after study 

      Raknes, Guttorm; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-01)
      <i>Background</i> - Low dose naltrexone (LDN) is reported to have beneficial effects in several autoimmune diseases. The purpose of this study was to examine whether starting LDN was followed by changes in the dispensing of thyroid hormones to patients with hypothyroidism.<p> <p><i>Methods</i> - We performed a quasi-experimental before-after study based on the Norwegian Prescription Database. ...
    • No effect of natural transformation on the evolution of resistance to bacteriophages in the Acinetobacter baylyi model system. 

      Mcleman, Amy; Sierocinski, Pawel; Hesse, E; Buckling, A; Perron, G; Hülter, Nils Fredrik; Johnsen, Pål Jarle; Vos, M (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      The adaptive benefits of natural transformation, the active uptake of free DNA molecules from the environment followed by incorporation of this DNA into the genome, may be the improved response to selection resulting from increased genetic variation. Drawing analogies with sexual reproduction, transformation may be particularly beneficial when selection rapidly fluctuates during coevolution with ...
    • The Norwegian Society for Pharmacoepidemiology 

      Lupattelli, Angela; Karlstad, Øystein; Engeland, Anders; Småbrekke, Lars; Olsen, Kristine; Øvrebust, Aina; Waaseth, Marit (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-16)
      The Norwegian Society for Pharmacoepidemiology (NFFE) is a multidisciplinary, nation-wide network of professionals involved in the field of pharmacoepidemiology. Pharmacoepidemiology is the science that bridges epidemiologic methodology with clinical pharmacology and clinical pharmacy, for studying the use, effectiveness, value and safety of pharmaceuticals1 . The foundation of NFFE took into ...
    • A Novel Approach for the Treatment of Aerobic Vaginitis: Azithromycin Liposomes-in-Chitosan Hydrogel 

      Cacic, Ana; Amidžic Klaric, Daniela; Keser, Sabina; Radikovic, Maja; Rukavina, Zora; Jøraholmen, May Wenche; Uzelac, Lidija; Kralj, Marijeta; Skalko-Basnet, Natasa; Segvic Klaric, Maja; Vanic, Zeljka (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-28)
      Biocompatible mucoadhesive formulations that enable a sustained drug delivery at the site of action, while exhibiting inherent antimicrobial activity, are of great importance for improved local therapy of vaginal infections. The aim of this research was to prepare and evaluate the potential of the several types of azithromycin (AZM)-liposomes (180–250 nm) incorporated into chitosan hydrogel (A ...
    • Novel in situ gel-forming solid dosage form (gfSDF) prepared by the simple syringe-based moulding: A screening study 

      Falavigna, Margherita; Skalko-Basnet, Natasa; Cavallari, Cristina; Pini, Andrea; Luppi, Barbara; Di Cagno, Massimiliano Pio (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-05)
      The aim of this study was to prepare and optimize a novel type of in situ gel-forming solid dosage form (gfSDF) to be used in the treatment of mucosal/skin ulcerations. For this purpose, a simple but reliable syringe-based hot melt/moulding method was employed. Chloramphenicol (antibiotic) and ibuprofen (anti-inflammatory) were chosen as model active pharmaceutical ingredients (APIs) to be loaded ...
    • Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors 

      Czarna, Anna Lucja; Jinhua, Wang; Zelencova, Diana; Liu, Yao; Deng, Xianming; Choi, Hwan Geun; Zhang, Tinghu; Zhou, Wenjun; Chang, Jae Won; Kildalsen, Hanne; Seternes, Ole Morten; Gray, Nathanael S.; Engh, Richard Alan; Rothweiler, Ulli (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-10)
      DYRK1A is one of five members of the dual-specificity tyrosine (Y) phosphorylation-regulated kinase (DYRK) family. The DYRK1A gene is located in the Down syndrome critical region and regulates cellular processes related to proliferation and differentiation of neuronal progenitor cells during early development. This has focused research on its role in neuronal degenerative diseases, including ...
    • Nucleic acid peptide nanogels for the treatment of bacterial keratitis 

      Obuobi, Sybil Akua Okyerewa; Mayandi, Venkatesh; Nurul, Azlyn Mohd Nor; Lee, Benedict Jiasheng; Lakshminarayanan, Rajamani; Pui Lai, Rachel Ee (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-14)
      Cage-shaped nucleic acid nanocarriers are promising molecular scaffolds for the organization of polypeptides. However, there is an unmet need for facile loading strategies that truly emulate nature's host–guest systems to drive encapsulation of antimicrobial peptides (AMPs) without loss of biological activity. Herein, we develop DNA nanogels with rapid in situ loading of L12 peptide during the thermal ...
    • Nucleic acids hybrids as advanced antibacterial nanocarriers 

      Obuobi, Sybil Akua Okyerewa; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-08)
      Conventional antibiotic therapy is often challenged by poor drug penetration/accumulation at infection sites and poses a significant burden to public health. Effective strategies to enhance the therapeutic efficacy of our existing arsenal include the use of nanoparticulate delivery platforms to improve drug targeting and minimize adverse effects. However, these nanocarriers are often challenged by ...
    • Ny diagnostikk for Alzheimers i Nytt Senter 

      Fjellaksel, Richard; Hjelstuen, Ole Kristian; Sundset, Rune (Chronicle; Kronikk, 2015-04-23)