Liver sinusoidal endothelial cells (LSECs) act as a filter between blood and the hepatocytes. LSECs are highly fenestrated cells; they contain transcellular pores with diameters between 50 to 200 nm. The small sizes of the fenestrae have so far prohibited any functional analysis with standard and advanced light microscopy techniques. Only the advent of super-resolution optical fluorescence microscopy ...

Succinate is an essential intermediate of the tricarboxylic acid cycle that exerts pleiotropic roles beyond metabolism in both physiological and pathological conditions. Recent evidence obtained in mouse models shows its essential role regulating blood cell function through various mechanisms that include pseudohypoxia responses by hypoxiainducible factor-1α activation, post-translational modifications ...

Background: This is a response to Conti et al.’s article, “Listening in the dark: why we need stories of people living with severe and enduring anorexia nervosa” (published in JED, 2016), and its call for relational metaphors and a rela tional approach to supplement the traditional medical/psychological diagnostic language used to describe the life experiences and complex emotions of people ...

<p><i>Background:</i> Multiple sclerosis (MS) is a severe chronic inflammatory disease in the central nervous system, mainly affecting young adults. The prevalence varies between different parts of the world, but the general rule is that it increases with increasing latitude. Studies on comorbid conditions in MS are limited, but this topic have gained increasing interest. <p><i>Aims:</i> To describe ...

Previous analyses of the Atlantic cod genome showed unique combinations of lacking and expanded number of genes for the immune system. The present study examined lysozyme activity, lysozyme gene distribution and expression in cod. Enzymatic assays employing specific bacterial lysozyme inhibitors provided evidence for presence of g-Type, but unexpectedly not for c-Type lysozyme activity. Database ...

The liver as the largest organ in the human body is composed of a complex macroscopic and microscopic architecture that supports its indispensable function to maintain physiological homeostasis. Optical imaging of the human liver is particularly challenging because of the need to cover length scales across 7 orders of magnitude (from the centimeter scale to the nanometer scale) in order to fully ...

Pain is common in otherwise healthy youth and is often associated with psychosocial problems. However, there is limited knowledge of how pain-troubled adolescents fare from adolescence into young adulthood. To examine this, the Norwegian Arctic Adolescent Health Study, a 10th grade school-based survey (15–16-year-olds) conducted in North Norway, in 2003–2005, was linked to the Norwegian Patient ...

Bakgrunn: Munchausen syndrom by proxy beskriver en lidelse der en forelder utsetter barnet sitt for flere unødvendige, skadelige og potensielt dødelige medisinske prosedyrer ved å falsifisere, produsere eller lyve om medisinske symptomer. Helsepersonell blir ufrivillig og ubevisst bidragsytere til mishandlingen i form av unødvendige utredninger og behandlinger. Formål: Hensikten med studien er å ...

Oppgaven er utformet som nettsiden ”Munn & Helse” (http://munnoghelse.unit5media.no/) og presenterer et utvalg av allmennmedisinske tilstander og deres orale aspekter. nettside med tittelen ”Munn & Helse” (http://munnoghelse.unit5media.no/) som presenterer et utvalg av allmennmedisinske tilstander og deres orale aspekter ( fig.2 og 3). Totalt 40 emner i kategoriene: hjerte-kar, diabetes, blødertilstander, ...

Objectives: The aim of our study was to get an overview of oral hygiene habits and the use of snus among high school graduates in Nordland county, and to investigate some background factors that may be associated with these habits. We also wanted to gain insight in the students’ motivation for maintaining good oral health, and to explore the influence of different factors around the use of snus. Material ...