Både i Norge og i andre land mottar stadig flere mennesker helsetjenester i sine egne hjem. Mange eldre voksne bor også hjemme så lenge som mulig, selv når de bor alene med skrøpelighet og helseutfordringer. Tidligere forskning viser at eldre voksnes erfaringer av skrøpelighet er dynamiske og nyanserte. Samtidig viser forskning også at dominerende masternarrativ om aldring og alderdom har en tendens ...

En rekke studier de senere år antyder at kjønn, alder og geografi er av betydning for håndtering av pasienter med mistenkt alvorlig skade. En ser at menn får mer avansert prehospital behandling, transporteres oftere til høyere omsorgsnivå og møtes oftere av traumeteam, sammenlignet med kvinner. Dette sees også når en justerer for skademekanisme. AMK-operatøren spiller en viktig rolle i ...

Successful management of patients suffering accidental hypothermia can be challenged by a circulatory dysfunction associated with impaired cardiac contractility and reduced intravascular volume. Furthermore, effects of medications can be altered during hypothermia. Despite reports demonstrating survival from hypothermic cardiac arrest (HCA) treated with cardiopulmonary resuscitation (CPR) and rewarming ...

Spørsmålet om hvordan hensynet til barnets beste skal vurderes i saker om endringer i skolestruktur, har fått økt oppmerksomhet både rettslig og politisk de siste årene. Dette har særlig aktualisert seg gjennom rettspraksis, nye lovbestemmelser, og en generell styrking av barns rettigheter i norsk og internasjonal rett. I tillegg har emnet fått en tydeligere plass i den offentlige debatten. <p> <p>Med ...

Aim: To assess associations between body fatness at a young age, weight change and adult pancreatic cancer risk Material and methods: Self-reported data on body type at age 7, weight at age 18 and weight and height at enrolment were included from 164,488 participants in the Norwegian Women and Cancer (NOWAC) cohort. Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% ...

Chronic musculoskeletal pain presents significant challenges for patients, clinicians, and healthcare systems, particularly due to the lack of clear prognosis, diagnosis, and etiological explanations, which increases uncertainty in consultations. This dissertation explores interactions in consultations with this patient group at a specialized rehabilitation clinic in Norway. The goal is to gain ...

For the first time, we have developed a liposomal formulation for Nω-hydroxy-nor-L-arginine (nor-NOHA). nor-NOHA is an arginase inhibitor that has potential in cancer treatment. The work aimed to develop a formulation that would have high encapsulation efficiency (EE%) for nor-NOHA in liposomes. Optimization of liposomes was conducted stepwise, namely liposomal characteristics were investigated ...

In the context of persistent wound infections, the delivery of antimicrobial agents is challenging. The bacterium in skin presents several strategies to avoid antimicrobial exposure by hiding inside cells and via the formation of biofilms. Additionally, several virulence strategies facilitate the progression of persistent bacterial infections. Although antibiotics are considered very advanced, they ...

Glioblastoma is the most lethal brain cancer, characterized by rapid growth and high mortality. Despite advances in diagnosis, surgery, and radiation therapy, glioblastoma remains resistant to treatment. One of the keys to successful anticancer drugs is their ability to reach the target site while minimizing accumulation in other tissues. Most drugs lack the physical and chemical properties and ...

Cancer immunotherapy has evolved significantly over the last decade, with therapeutics targeting the adaptive immune system showing exciting effects in clinics. Yet, the modulation of the innate immune system, particularly the tumor-associated innate immune cells which are an integral part of immune responses in cancer, remains less understood. The arginase 1 (Arg1) pathway is a pivotal metabolic ...