The post-World War II years in the Arctic were characterised by an intensification of sociocultural change. Previous studies among indigenous peoples show that colonialism, rapid modernisation and subsequent marginalisation and sociocultural change are accompanied by overall ill health and a negative cardiovascular risk profile and disease burden. Paper I showed that aggregate acculturation was a ...

In this thesis I present empirical insight to socio-technical challenges of standardising large-scale healthcare information infrastructures (II). The main focus was how to balance the requirements between technological, organizational, and user related requirements in large-scale IIs, as well as the power balance between the actors, and the need for extensive user involvement in such standardization. ...

Wild rats employ a rather extensive area for their daily activities and share elaborate burrows with tunnel and chambers. When a female enters estrus, she will copulate with multiple males during the entire period of estrus. In a typical laboratory setting, rat sexual behavior is studied in pairs of opposite sex individuals. Apparently the experimental studies have been performed in this highly ...

Research has demonstrated that inflammation is a central part of several psychiatric disorders, of which depression in the most researched condition. Most studies have, however, been conducted on younger adults, and studies on elderly are scarce. This thesis explores the possible association between systemic markers of inflammation and characteristics of older psychiatric patients. In study I, ...

Studien «Speaking on behalf of the person with dementia in home-based care» viser en rekke krevende barrierer for samhandling i demensomsorg i norske kommuner. Disse barrierene har negativ påvirkning på hvilke hjelpetilbud som tilbys og hvordan familier nyttiggjør seg disse, noe som igjen har betydning for oppnåelse av helsepolitiske mål og pasientrettigheter. I kommuner med både norsk og samisk ...

Trauma-specific treatment groups have traditionally been offered based on the type of trauma exposure. This has left such treatment unavailable to trauma clients in areas where homogenous trauma groups cannot be offered, such as rural areas. In this thesis a new treatment approach is presented, an inclusive stabilization group, which can be applied in a broader range of settings. Qualitative, ...

Background: S. aureus colonizes persistently 20–30% of the adult human population (S. aureus carriers), and can also cause serious infections. The main objectives of this thesis were to investigate whether the modifiable risk factors such as serum vitamin D levels and obesity, and environmental factors such as current smoking, being a healthcare worker and residing with children were associated ...

Cholecalciferol (vitamin D) is a biologically active substance, which acts in both skeletal and non-skeletal metabolic pathways, and is stored most in adipose tissue. Its active metabolite 1,25-dihydroxyvitamin D (1,25(OH)2D), bound to the vitamin D receptor (VDR), regulates gene expression and initiates rapid responses in the cells that regulate bone and adipose tissue homeostasis, lead to ...

The emergence of multidrug-resistant (MDR) Gram-negative pathogens and lack of new antibiotics in the pharmaceutical pipeline is seriously limiting our treatment options against common infections. We are now experiencing clinical isolates resistant to virtually all our antibiotics. Our most important and widely used antibiotics, the β-lactams, are challenged by successful β-lactamases. β-lactamases ...

Den tre-dimensjonale (3D) strukturen til serotonin-transporteren er ukjent og arbeidet som beskrives i avhandlingen er basert på teoretiske 3D-modeller av transporteren. Modellene har blitt brukt til å simulere bevegelsene i transporterstrukturen som skjer når serotonin transporteres samt til å studere hvordan forbindelser som blokkerer transporten binder til transporteren. For å gjøre det sistnevnte ...