Doktorgradsavhandlinger (Helsefak): Nye registreringer
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Metacognition and decision-making in schizophrenia: Exploring how aberrant processing and representation of uncertainty may explain cognitive-behavioral biases
(Doctoral thesis; Doktorgradsavhandling, 2021-04-13)The cognitive profile associated with schizophrenia has long been a research subject of interest. A plethora of studies have not only revealed cognitive deficits but also cognitive biases, meaning qualitative deviations in the way information is processed and evaluated. Such biases are for example reflected in findings of diminished metacognitive accuracy, or premature and disadvantageous decision-making. ... -
Biomarkers of major bleeding after incident venous thromboembolism
(Doctoral thesis; Doktorgradsavhandling, 2021-03-23)Major bleeding (MB) events are feared and potentially fatal complications of anticoagulant treatment in patients with venous thromboembolism (VTE). Even though several clinical risk factors are associated with MB risk, the predictive power of currently available risk assessment models remain limited for VTE. The aim of this thesis was to identify biomarkers of MB risk during the first year after an ... -
A biomarker approach to explain high cardiovascular disease burden in Russia: insights from population-based studies in Russia and Norway
(Doctoral thesis; Doktorgradsavhandling, 2021-03-25)Although the problem of cardiovascular disease (CVD) in Russia has been the subject of attention for decades, a definitive and comprehensive explanation of why the CVD burden there is so high and generally greater than in many other countries has still not been found. In this thesis, I have attempted to advance research on these issues by examining the role of blood lipids, heart damage biomarkers ... -
mHealth: opportunities and challenges for diabetes intervention research
(Doctoral thesis; Doktorgradsavhandling, 2021-03-12)<p><i>Background:</i> Traditionally, health intervention evaluations provide long-term evidence of efficacy and safety via validated protocols, following a positivist paradigm, or approach, to research. However, modern mobile health (mHealth) technologies develop too quickly and outside of medical regulation, making it challenging for health research to keep pace. <p><i>Objective:</i> This thesis ... -
Hvordan kan universitetet ivareta sitt samfunnsoppdrag: med eksempler fra sykepleierutdanningen i Finnmark
(Doctoral thesis; Doktorgradsavhandling, 2021-03-12)Avhandlingen består av seks artikler basert på studier fra sykepleierutdanning i Finnmark, og belyser ulike aspekter ved sykepleierutdanningens samfunnsoppdrag. Hensikten med artiklene er å bidra til økt kunnskap om urfolksperspektiv, utfordringer som stabilisering og rekruttering av sykepleiere til distriktene, samhandling mellom primær- og spesialisthelsetjeneste, samt pedagogiske tilnærminger ... -
Chronic Pelvic Pain in women. Group based multimodal physical therapy
(Doctoral thesis; Doktorgradsavhandling, 2021-02-26)<p><i>Introduction - </i>The aims of this thesis were (1) to describe the characteristics of women with chronic pelvic pain (CPP) referred for physical therapy after evaluation at a tertiary hospital, (2) to compare group-based multimodal physical therapy (intervention group) with primary care physical therapy (comparator group), and (3) to explore if selected pre-treatment characteristics were ... -
Biocompatibility in low-density lipoprotein apheresis and plasma separation
(Doctoral thesis; Doktorgradsavhandling, 2021-02-12)<p><i>Introduction:</i> Low-density lipoprotein (LDL) apheresis is used for the removal of LDL in selected patients and is also used for other medical indications. This thesis aimed to systematically study how different LDL apheresis systems affected the immune system in a biocompatibility perspective under in vivo and ex vivo conditions. <p><i>Methods:</i> Whole blood adsorption, dextran sulfate ... -
Cardiovascular risk factors and incidence of acute myocardial infarction and cerebral stroke in Sami and non-Sami populations — The SAMINOR Study
(Doctoral thesis; Doktorgradsavhandling, 2021-02-08)The overall aim of this thesis was to examine and compare cardiovascular risk factors, time-trends in these risk factors, and the incidence of cardiovascular disease in Sami and non-Sami populations living in the same rural geographical area. We used information from the SAMINOR Study, which is a Population-based Study on Health and Living Conditions in Regions with Sami and Norwegian Populations. ... -
Physical Activity and Body Composition in Norwegian Adolescents. Results from The Tromsø Study: Fit Futures
(Doctoral thesis; Doktorgradsavhandling, 2021-02-04)The present thesis has investigated the cross-sectional and prospective associations between self-reported and objectively measured physical activity with five objectively measured indices of body composition in Norwegian adolescents participating in the Tromsø Study Fit: Futures Cohort. The three included papers used regression analyses to assess the cross-sectional association between self-reported ... -
Unraveling nanoscale alterations in liver cell fenestrations - Morphological studies via optical super-resolution microscopy approaches
(Doctoral thesis; Doktorgradsavhandling, 2021-01-22)The endothelium makes up the innermost cell layer of blood vessels. It consists of a thin layer of simple squamous cells, forming an interface between circulating blood and the surrounding tissue. Endothelial cells of different vascular beds are specialized according to tissue-specific functions. For this project emphasis was placed upon high-resolution methods enabling the study of liver sinusoidal ... -
Bacterial Extracellular vesicles and their cargo
(Doctoral thesis; Doktorgradsavhandling, 2021-02-05)<i>Staphylococcus aureus</i> and <i>Enterococcus faecium</i> are opportunistic pathogens that may cause diseases ranging from minor skin infection to severe blood stream infections. The emergence of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) and vancomycin-resistant enterococcal strains severely limits treatment options. Bacteria release extracellular vesicles (EVs), defined as ... -
Human platelet antigen (HPA)-1a alloimmunization - Why only blame it on the platelets?
(Doctoral thesis; Doktorgradsavhandling, 2021-01-15)Antibodies against human platelet antigen (HPA)-1a are the most common cause of fetal and neonatal alloimmune thrombocytopenia (FNAIT) in Caucasians, and is a break of the tolerance normally seen for the fetus in pregnant women. The initiation of immunization is suggested to be feto-maternal transfer of platelets during pregnancy and at delivery, and one of the consequences of anti-HPA-1a antibodies ... -
Acute intermittent porphyria. Inflammation, diet and biomarkers in acute intermittent porphyria
(Doctoral thesis; Doktorgradsavhandling, 2021-01-22)Acute intermittent porphyria (AIP) is a rare autosomal dominant inherited metabolic disease with lowered function of the enzyme hydroxymethylbilan synthase due to mutation in this gene of the heme synthesis. The resulting excess of aminolevulinic acid and porphobilinogen can result in acute abdominal pain, paresis, fatigue, increased risk for kidney failure and hepatocellular carcinoma. Some drugs, ... -
Transcranial Direct Current Stimulation as a memory enhancer in healthy participants and patients with Alzheimer`s disease
(Doctoral thesis; Doktorgradsavhandling, 2020-12-18)<p>The aim of this thesis was to investigate the effects of transcranial direct current stimulation (tDCS) as a memory enhancer in Alzheimer’s disease patients and healthy individuals. In addition, we wanted to study how verbal memory functions are related to hippocampus subfield volumes. <p>This thesis consists of three reports, in which two of the reports (I and II) aimed to study the effects of ... -
Suicide among Sámi – Cultural meanings of suicide and interventions for suicide prevention in Nordic parts of Sápmi
(Doctoral thesis; Doktorgradsavhandling, 2020-12-17)<p><i>Background:</i> In suicidological research, it is well known that suicide rates differ, sometimes to a great extent, between countries, sexes, religious and ethnic populations. It has been suggested that in-depth exploration of social, cultural, contextual and historical perspectives on suicide is needed to explain this, and increase efficacy of prevention efforts. Sámi are the Indigenous ... -
Perinatal mortality and its association with antenatal care utilization in the Republic of Georgia
(Doctoral thesis; Doktorgradsavhandling, 2020-12-11)<p><i>Background:</i> Despite recent achievements, perinatal mortality (PM) rates remain high worldwide, especially in low-income countries (>30 per 1000 births). PM is defined as the death of a fetus/livebirth between 22 completed weeks of gestation and the first 7 days of life. Simple, non-invasive interventions could reduce PM rates, since most deaths are caused by preventable conditions. Adequate ... -
Arctic food biographies. An ethnographic study of food and health in everyday life of elderly Arctic women
(Doctoral thesis; Doktorgradsavhandling, 2020-12-04)<p>The aim of the ethnographic study described was to listen sensitively and give voice to elderly Arctic women’s personal food biographies and everyday experiences of living in small coastal towns and inland areas of Norway’s Circumpolar North, North West Russia and Greenland. These specified geographical contexts were selected because they have been the focus of the Arctic and Global Health research ... -
A Shotgun-metagenomics approach for laboratory diagnostics in clinical microbiology
(Doctoral thesis; Doktorgradsavhandling, 2020-11-12)Shotgun-metagenomics (SMg) has a huge potential, particularly in clinical microbiology where conventional diagnostic methods have limitations such as diagnosis of prosthetic joint infection (PJI). The main objective of this project was to explore the use of SMg in clinical diagnostics of PJI directly from blood culture bottles (BCBs) inoculated with PJT specimens. First, we assessed the use of a ... -
Dietary intake of marine polyunsaturated fatty acids and incidence, recurrence and mortality related to venous thromboembolism
(Doctoral thesis; Doktorgradsavhandling, 2020-11-27)Venøs tromboembolisme (VTE) er en fellesbetegnelse på dyp venetrombose (DVT) og lungeemboli (LE). VTE er en vanlig og alvorlig karsykdom hvor forekomsten har vært svakt økende de siste årene. Marine omega-3 fettsyrer (n-3 PUFAs) har flere gunstige effekter på hemostasemekanismen. Målet med denne doktorgradsavhandlingen var å undersøke sammenhengen mellom inntak av marine n-3 PUFAs i kosten og risikoen ... -
Sexual function and lifestyle behavior among lymphoma survivors after high dose chemotherapy with autologous stem-cell transplantation
(Doctoral thesis; Doktorgradsavhandling, 2020-10-22)<p><i>Background/Aims:</i> Lymphoma is one of the most prevalent malignancies among young persons. The survival rate is high, though comes with a risk of late effects including secondary cancer, cardiovascular disease (CVD) and chronic fatigue (CF). Some lymphoma patients require especially intensive treatment, high dose chemotherapy with autologous stem-cell transplantation (auto-SCT), to achieve ...