Body-weight supported locomotor training (BWSLT) has been used to improve walking function in subjects with incomplete Spinal Cord Injuries (SCI), but randomized controlled trials (RCTs) among subjects with long-standing (>2 years) incomplete SCI and poor walking function are scarce. This research aims to describe the methodology and report the results from two parallel, but independent, single-blinded ...

School nursing involves relationships and understandings based on young people’s needs. Visual technologies have become a central part of young people’s life and context: they use their phones to communicate and shape their relationships and they turn to social media when inquiring about health issues. Visual methods in health communication thus draw on existing practices, and are well documented ...

Denne studien har som overordnet mål å utforske livskvalitet og funksjon etter hjerneslag i en region i Nord Norge og en region i Midt Jylland i Danmark med ulik organisering i rehabiliteringstjenester. I dette prosjektet ble det benyttet både kvalitative dybdeintervju og selv-rapporterte spørreskjema i et 'mixed methods' metodisk design. Livskvalitet og funksjon undersøkes i lys av ulike ...

Irritable bowel syndrome (IBS) is common disorder of the lower gastro intestinal tract associated with a poor quality of life. Revealing the interplay between the microbiota and the host has lead to a better understanding of IBS. A disturbance in the bidirectional communication in the microbiota-gut-brain axis is suggested to be involved in the pathophysiology of IBS. The microbiota in this context ...

Staphylococcus haemolyticus is a ubiquitous bacterium recognised as a significant cause of nosocomial infections. Today it represents one of the most clinically relevant staphylococcal species, hallmarked by its extreme genome plasticity and multiresistant phenotype. Despite its relevance, little is known about its virulence repertoire or how it causes disease. The main objective of this PhD thesis ...

The aims of this thesis were to study CR participation rate, clinically relevant anxiety and depression and employment status of patients following percutaneous coronary intervention (PCI), and the long-term effect of participation in a CR programme on patients’ symptoms of anxiety and depression and their employment status. Using a prospective observational design, we included data from the Norwegian ...

Colorectal cancer (CRC) is a major global disease. The incidence rate among Norwegian women is currently the highest in the world. Lifestyle factors have a substantial influence on CRC susceptibility. However, it is not clear whether these factors are responsible for the high incidence in Norwegian women, or whether they play a role in CRC survival. This doctoral project investigated lifestyle factors ...

Endoplasmic reticulum (ER) and Golgi apparatus are key organelles in the synthesis, modification and trafficking of proteins in eukaryotic cells. In response to stress stimuli such as nutrients deprivation, accumulation of misfolded proteins or exposure to chemicals, the ER increases in size through increased synthesis of its components to counteract the stress. Similarly, Golgi response to stress ...

<p>TRIM proteins are ubiquitin E3 ligases known to be involved in a number of different processes in the cells, such as intracellular signaling, transcription, autophagy, innate immunity, cell cycle progression and DNA repair. Mutations and dysregulation of TRIM proteins are implicated in many diseases, and a number of TRIMs are described as both tumor suppressors and oncogenes. Furthermore, several ...

<p>Children of parents with serious forms of illness have shown to be vulnerable to developing a wide variety of psychosocial problems themselves. The research literature strongly indicates that preventive interventions may protect against well-documented transgenerational risk factors and strengthen the children’s resilience by promoting protective factors. Despite this knowledge, there is a gap ...