Browsing Artikler, rapporter og annet (medisinsk biologi) by Title

Now showing items 501-520 of 1054

    • The inflammation repressor TNIP1/ABIN-1 is degraded by autophagy following TBK1 phosphorylation of its LIR 

      Rasmussen, Nikoline Lander; Zhou, Jianwen; Olsvik, Hallvard Lauritz; Kaeser-Pebernard, Stéphanie; Lamark, Trond; Dengjel, Joern; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-09)
      The inflammatory repressor TNIP1/ABIN-1 is important for keeping in check inflammatory and cell-death pathways to avoid potentially dangerous sustained activation of these pathways. We have now found that TNIP1 is rapidly degraded by selective macroautophagy/autophagy early (0–4 h) after activation of TLR3 by poly(I:C)-treatment to allow expression of pro-inflammatory genes and proteins. A few hours ...

    • Inflammatory serum markers and risk and severity of prostate cancer: The PROCA‐life study 

      Stikbakke, Einar; Richardsen, Elin; Knutsen, Tore; Wilsgaard, Tom; Giovannucci, Edward L; McTiernan, Anne; Thune, Inger (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-03)
      Whether chronic inflammation mirrored by high levels of systemic inflammatory markers such as high sensitive‐CRP (hs‐CRP) and white blood cell count (WBC) are associated with prostate cancer development remains unclear. In the Prostate Cancer Study throughout Life (PROCA‐<i>life</i>), a prospective population‐based cohort study, 7,356 men were included. Prediagnostic WBC and hs‐CRP were assessed ...

    • The influence of a series of five dry cupping treatments on pain and mechanical thresholds in patients with chronic non-specific neck pain : a randomised controlled pilot study 

      Lauche, Romy; Cramer, Holger; Choi, Kyung-Eun; Rampp, Thomas; Saha, Felix Joyonto; Dobos, Gustav J.; Musial, Frauke (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      In this preliminary trial we investigated the effects of dry cupping, an ancient method for treating pain syndromes, on patients with chronic non-specific neck pain. Sensory mechanical thresholds and the participants’ self-reported outcome measures of pain and quality of life were evaluated. Fifty patients (50.5 ± 11.9 years) were randomised to a treatment group (TG) or a waiting-list control group ...

    • Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls 

      Timofeeva, MN; Hung, RJ; Rafnar, T; Christiani, DC; Field, JK; Bickeboller, H; Risch, A; McKay, JD; Wang, Y; Dai, J; Gaborieau, V; McLaughlin, J; Brenner, D; Narod, SA; Caporaso, NE.; Albanes, D; Thun, M; Eisen, T; Wichmann, HE; Rosenberger, A; Han, Y; Chen, W; Zhu, D; Spitz, M; Wu, X; Pande, M; Zhao, Y; Zaridze, D; Szeszenia-Dabrowska, N; Lissowska, J; Rudnai, P; Fabianova, E; Mates, D; Bencko, V; Foretova, L; Janout, V; Krokan, Hans Einar; Gabrielsen, Maiken Elvestad; Skorpen, Frank; Vatten, Lars Johan; Njølstad, Inger; Chen, C; Goodman, G; Lathrop, M; Benhamou, S; Vooder, T; Valk, K; Nelis, M; Metspalu, Andres; Raji, O; Chen, Y; Gosney, J; Liloglou, T; Muley, T; Dienemann, H; Thorleifsson, G; Shen, H.; Stefansson, Kari; Brennan, Paul; Amos, CI; Houlston, Richard; Landi, MT (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Recent genome-wide association studies (GWASs) have identified common genetic variants at 5p15.33, 6p21–6p22 and 15q25.1 associated with lung cancer risk. Several other genetic regions including variants of CHEK2 (22q12), TP53BP1 (15q15) and RAD52 (12p13) have been demonstrated to influence lung cancer risk in candidate- or pathway-based analyses. To identify novel risk variants for lung cancer, we ...

    • Inhibition of ABCC5-mediated cGMP transport by progesterone, testosterone and their analogues 

      Odland, Sondre Ulstein; Ravna, Aina Westrheim; Smaglyukova, Natalia; Dietrichs, Erik Sveberg; Sager, Georg (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-13)
      The biodynamics and biokinetics of sex hormones are complex. In addition to the classical steroid receptors (nuclear receptors), these hormones act through several non-genomic mechanisms. Modulation of ABC-transporters by progesterone represents a non-genomic mechanism. In the present study, we employed inside out vesicles from human erythrocytes to characterize high affinity cGMP transport by ABCC5 ...

    • Inhibition of bacterial and human zinc-metalloproteases by bisphosphonate- and catechol-containing compounds 

      Rahman, Fatema; Nguyen, Tra-Mi; Adekoya, Olayiwola; Campestre, Cristina; Tortorella, Paolo; Sylte, Ingebrigt; Winberg, Jan-Olof (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-23)
      Compounds containg catechol or bisphosphonate were tested as inhibitors of the zinc metalloproteases, thermolysin (TLN), pseudolysin (PLN) and aureolysin (ALN) which are bacterial virulence factors, and the human matrix metalloproteases MMP-9 and −14. Inhibition of virulence is a putative strategy in the development of antibacterial drugs, but the inhibitors should not interfere with human enzymes. ...

    • Inhibition of chemerin/CMKLR1 axis in neuroblastoma cells reduces clonogenicity and cell viability in vitro and impairs tumor growth in vivo 

      Tümmler, Conny; Snapkov, Igor; Wickström, Malin; Moens, Ugo; Ljungblad, Linda; Elfman, Maria; Winberg, Jan-Olof; Kogner, Per; Johnsen, John Inge; Sveinbjørnsson, Baldur (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-27)
      Pro-inflammatory cells, cytokines, and chemokines are essential in promoting a tumor supporting microenvironment. Chemerin is a chemotactic protein and a natural ligand for the receptors CMKLR1, GPR1, and CCRL2. The chemerin/CMKLR1 axis is involved in immunity and inflammation, and it has also been implicated in obesity and cancer.<p> In neuroblastoma, a childhood tumor of the peripheral nervous ...

    • Inhibition of PDE5A1 guanosine cyclic monophosphate (cGMP) hydrolysing activity by sildenafil analogues that inhibit cellular cGMP efflux 

      Subbotina, Anna; Ravna, Aina Westrheim; Lyså, Roy Andre; Abagyan, Ruben; Bugno, Ryszard; Sager, Georg (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-17)
      <p><i>Objectives</i>: To determine the ability of 11 sildenafil analogues to discriminate between cyclic nucleotide phosphodiesterases (cnPDEs) and to characterise their inhibitory potencies (<kursiv>K</kursiv><sub>i</sub> values) of PDE5A1‐dependent guanosine cyclic monophosphate (cGMP) hydrolysis.</p> <p><i>Methods</i>: Sildenafil analogues were identified by virtual ligand screening (VLS) ...

    • The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk 

      Campa, D; Lund, Eiliv; Husing, A; McKay, JD; Sinilnikova, OM; Vogel, U; Tjonneland, A; Overvad, K; Stegger, J; Clavel-Chapelon, F; Chabbert-Buffet, N; Fagherazzi, G; Trichopoulou, A; Zylis, D; Oustoglou, E; Rohrmann, S; Teucher, B; Fisher, E; Boeing, H; Masala, G; Krogh, V; Sacerdote, C; Panico, S; Tumino, R; Onland-Moret, NC; van Gils, CH; Bueno-de-Mesquita, H. Bas; Chirlaque, MD; Sala, Núria; Quiros, JR; Ardanaz, E; Amiano, P; Molina-Montes, E; Hallmans, G; Lenner, P; Travis, R; Key, TJ; Wareham, N; Khaw, KT; Rinaldi, S; Slimani, N; Chajes, V; Siddiq, A; Riboli, E; Kaaks, R; Canzian, F (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)

    • Integrative metabolic and transcriptomic profiling of prostate cancer tissue containing reactive stroma 

      Andersen, Maria Karoline; Rise, Kjersti; Giskeødegård, Guro F.; Richardsen, Elin; Bertilsson, Helena; Størkersen, Øystein; Bathen, Tone Frost; Rye, Morten Beck; Tessem, May-Britt (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-24)
      Reactive stroma is a tissue feature commonly observed in the tumor microenvironment of prostate cancer and has previously been associated with more aggressive tumors. The aim of this study was to detect differentially expressed genes and metabolites according to reactive stroma content measured on the exact same prostate cancer tissue sample. Reactive stroma was evaluated using histopathology from ...

    • Integron, plasmid and host strain characteristics of Escherichia coli from humans and food included in the Norwegian antimicrobial resistance monitoring programs 

      Sunde, Marianne; Simonsen, Gunnar Skov; Slettemeås, Jannice Schau; Bøckerman, Inger; Norström, Madelaine (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-05)
      Antimicrobial resistant Escherichia coli (n=331) isolates from humans with bloodstream infections were investigated for the presence of class 1 and class 2 integrons. The integron cassettes arrays were characterized and the findings were compared with data from similar investigations on resistant E. coli from meat and meat products (n=241) produced during the same time period. All isolates were ...

    • Intensity Dependent Confidence Intervals on Microarray Measurements of Differentially Expressed Genes : A Case Study of the Effect of MK5, FKRP and TAF4 on the Transcriptome 

      Jakobsen, Kirsti; Van, Belle Werner; Gerits, Nancy; Brox, Vigdis; Van Ghelue, Marijke; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2007)

    • Inter-rater reliability of a national acute stroke register 

      Varmdal, Torunn; Ellekjær, Hanne; Fjærtoft, Hild; Indredavik, Bent; Lydersen, Stian; Bønaa, Kaare Harald (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10-19)
      <p>Background: Medical quality registers are useful sources of knowledge about diseases and the health services. However, there are challenges in obtaining valid and reliable data. This study aims to assess the reliability in a national medical quality register. <p>Methods: We randomly selected 111 patients having had a stroke in 2012. An experienced stroke nurse completed the Norwegian Stroke ...

    • The interaction between Staphylococcus aureus SdrD and desmoglein 1 is important for adhesion to host cells 

      Askarian, Fatemeh; Ajayi, Clement; Hanssen, Anne-Merethe; Van Sorge, Nina M.; Pettersen, Ingvild; Diep, Dzung Bao; Sollid, Johanna U. Ericson; Johannessen, Mona (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-29)
      <i>Staphylococcus aureus</i> is known as a frequent colonizer of the skin and mucosa. Among bacterial factors involved in colonization are adhesins such as the microbial surface components recognizing adhesive matrix molecules (MSCRAMMs). Serine aspartate repeat containing protein D (SdrD) is involved in adhesion to human squamous cells isolated from the nose. Here, we identify Desmoglein 1 ...

    • The Interaction Between Venous Thromboembolism and Socioeconomic Status on the Risk of Disability Pension 

      Jørgensen, Helle; Horváth-Puhó, Erzsébet; Laugesen, Kristina; Brækkan, Sigrid Kufaas; Hansen, John Bjarne; Sørensen, Henrik Toft (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-14)
      Background: Venous thromboembolism (VTE) is associated with increased risk of disability pension. How socioeconomic status (SES) impacts the risk of disability pension after a VTE is unknown. The aim of this nationwide population based cohort study to investigate the interaction between SES and incident VTE on the risk of subsequent disability pension.<p> <p>Methods: Using Danish national medical ...

    • Interleukin-1β as emerging therapeutic target in hematological malignancies and potentially in their complications 

      Arranz, Lorena; Arriero Sanchez, Maria Del Mar; Villatoro, Alicia (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-03)
      Interleukin-1β (IL-1β) is a pleiotropic cytokine that exerts multiple roles in both physiological and pathological conditions. It is produced by different cell subsets, and drives a wide range of inflammatory responses in numerous target cells. Enhanced IL-1β signaling is a common event in patients of hematological malignancies. Recent body of evidence obtained in preclinical models shows the ...

    • The International Collaboration on Complementary Therapy Resources (ICCR) : working together to improve online CAM information 

      Pilkington, Karen; Gamst, are; Liu, Irene; Ostermann, Thomas; Pinto, Dimitry; Richardon, Janet (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Use of the Internet to find health information is increasing dramatically but the quality of information, particularly on complementary and alternative medicine (CAM) is variable. The International Collaboration on Complementary Therapy Resources (ICCR) involves collaboration between the national CAM information centers in Australia, Denmark, Norway, the United Kingdom, and the United States, and a ...

    • Interobserver Reliability of Four Diagnostic Methods Using Traditional Korean Medicine for Stroke Patients 

      Lee, Ju Ah; Ko, Mi Mi; Kang, Byoung-Kab; Alræk, Terje; Birch, Stephen; Lee, Myeong S. (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Interplay of immune and kidney resident cells in the formation of tertiary lymphoid structures in lupus nephritis 

      Jamaly, Simin; Rakaee, Mehrdad; Abdi, Reza; tsokos, George; Fenton, Kristin Andreassen (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-27)
      Kidney involvement confers significant morbidity and mortality in patients with systemic lupus erythematosus (SLE). The pathogenesis of lupus nephritis (LN) involves diverse mechanisms instigated by elements of the autoimmune response which alter the biology of kidney resident cells. Processes in the glomeruli and in the interstitium may proceed independently albeit crosstalk between the two is ...

    • The interplay of matrix metalloproteinase-8, transforming growth factor-β1 and vascular endothelial growth factor-C cooperatively contributes to the aggressiveness of oral tongue squamous cell carcinoma 

      Åström, Pirjo; Juurikka, Krista; Hadler-Olsen, Elin Synnøve; Svineng, Gunbjørg; Cervigne, Nilva K.; Coletta, Ricardo D.; Risteli, Juha; Kauppila, Joonas H.; Skarp, Sini; Kuttner, Samuel; Oteiza, Ana; Sutinen, Meeri; Salo, Tuula (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-03)
      Background: Matrix metalloproteinase-8 (MMP-8) has oncosuppressive properties in various cancers. We attempted to assess MMP-8 function in oral tongue squamous cell carcinoma (OTSCC).<p> <p>Methods: MMP-8 overexpressing OTSCC cells were used to study the effect of MMP-8 on proliferation, apoptosis, migration, invasion and gene and protein expression. Moreover, MMP-8 functions were assessed in the ...