Blar i tittel Artikler, rapporter og annet (medisinsk biologi)

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    • Liver sinusoidal endothelial cells contribute to the uptake and degradation of entero bacterial viruses 

      Øie, Cristina Ionica; Wolfson, Deanna; Yasunori, Tanji; Dumitriu, Gianina; Sørensen, Karen Kristine; McCourt, Peter Anthony; Ahluwalia, Balpreet Singh; Smedsrød, Bård (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-21)
      The liver is constantly exposed to dietary antigens, viruses, and bacterial products with inflammatory potential. For decades cellular uptake of virus has been studied in connection with infection, while the few studies designed to look into clearance mechanisms focused mainly on the role of macrophages. In recent years, attention has been directed towards the liver sinusoidal endothelial cells ...

    • Liver sinusoidal endothelial cells represents an important blood clearance system in pigs 

      Nedredal, Geir I.; Elvevold, Kjetil H.; Olsen, Randi; Ytrebø, Lars M.; Revhaug, Arthur; Smedsrød, Bård (Journal article; Tidsskriftartikkel; Peer reviewed, 2003-01-03)
      Background: Numerous studies in rats and a few other mammalian species, including man, have shown that the sinusoidal cells constitute an important part of liver function. In the pig, however, which is frequently used in studies on liver transplantation and liver failure models, our knowledge about the function of hepatic sinusoidal cells is scarce. We have explored the scavenger function of pig ...

    • Liver sinusoidal endothelial cells show reduced scavenger function and downregulation of Fc gamma receptor IIB, yet maintain a preserved fenestration the Glmp gt/gt mouse model of slowly progressing liver fibrosis 

      Antwi, Milton Boaheng; Dumitriu, Gianina; Simón-Santamaria, Jaione; Sánchez Romano, Javier; Li, Ruomei; Smedsrød, Bård; Vik, Anders; Eskild, Winnie; Sørensen, Karen Kristine (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-01)
      Liver sinusoidal endothelial cells (LSECs) are fenestrated endothelial cells with a unique, high endocytic clearance capacity for blood-borne waste macromolecules and colloids. This LSEC scavenger function has been insufficiently characterized in liver disease. The Glmp<sup>gt/gt</sup> mouse lacks expression of a subunit of the MFSD1/GLMP lysosomal membrane protein transporter complex, is born ...

    • Liver X receptors induce antiproliferative effects in basal-like breast cancer 

      Haugen, Mads; von der Lippe Gythfeldt, Hedda; Egeland, Eivind Valen; Svartdal Normann, Lisa; Pandya, Abhilash D.; Vedin, Lise-Lotte; Juell, Siri; Tenstad, Ellen; Øy, Geir Frode; Kristian, Alexandr; Marangoni, Elisabetta; Sørlie, Therese; Steffensen, Knut Rune; Mælandsmo, Gunhild Mari; Engebråten, Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-21)
      Liver X receptors (LXRs) are nuclear transcription factors important in the regulation of cholesterol transport, and glucose and fatty acid metabolism. The antiproliferative role of LXRs has been studied in a variety of malignancies and may represent a therapeutic opportunity in cancers lacking targeted therapies, such as triple-negative breast cancer. In this study, we investigated the impact of ...

    • LMW Heparin Prevents Increased Kidney Expression of Proinflammatory Mediators in (NZBxNZW)F1 Mice 

      Hedberg, Annica; Kanapathippillai, Premasany; Rekvig, Ole Petter; Fenton, Kristin Andreassen (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      We have previously demonstrated that continuous infusion of low molecular weight (LMW) heparin delays autoantibody production and development of lupus nephritis in (NZBxNZW)F1 (B/W) mice. In this study we investigated the effect of LMW heparin on renal cytokine and chemokine expression and on nucleosome-mediated activation of nucleosome-specific splenocytes. Total mRNA extracted from kidneys of ...

    • Localization of Staphylococcus aureus in tissue from the nasal vestibule in healthy carriers 

      Hanssen, Anne-Merethe; Kindlund, Bert; Stenklev, Niels Christian; Furberg, Anne-Sofie; Fismen, Silje; Olsen, Renate Slind; Johannessen, Mona; Sollid, Johanna U Ericson (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-05)
      <p><b>Background:</b> Colonization of the body is an important step in Staphylococcus aureus infection. S. aureus colonizes skin and mucous membranes in humans and several animal species. One important ecological niche of S. aureus is the anterior nares. More than 60% of the S. aureus in the nose are found in vestibulum nasi. Our aim was to describe the localization of S. aureus in nasal tissue ...

    • The long noncoding RNA CCAT2 induces chromosomal instability through BOP1-AURKB signaling 

      Chen, Baoqing; Dragomir, Mihnea Paul; Fabris, Linda; Bayraktar, Recep; Knutsen, Erik; Liu, Xu; Tang, Changyan; Li, Yongfeng; Shimura, Tadanobu; Ivkovic, Tina Catela; Cruz De los Santos, Mireia; Anfossi, Simone; Shimizu, Masayoshi; Shah, Maitri Y.; Ling, Hui; Shen, Peng; Multani, Asha S.; Pardini, Barbara; Burks, Jared K.; Katayama, Hiroyuki; Reineke, Lucas C.; Huo, Longfei; Syed, Muddassir; Song, Shumei; Ferracin, Manuela; Oki, Eiji; Fromm, Bastian; Ivan, Cristina; Bhuvaneshwar, Krithika; Gusev, Yuriy; Mimori, Koshi; Menter, David; Sen, Subrata; Matsuyama, Takatoshi; Uetake, Hiroyuki; Vasilescu, Catalin; Kopetz, Scott; Parker-Thornburg, Jan; Taguchi, Ayumu; Hanash, Samir M.; Girnita, Leonard; Slaby, Ondrej; Goel, Ajay; Varani, Gabriele; Gagea, Mihai; Li, Chunlai; Ajani, Jaffer A.; Calin, George A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-15)
      Background & Aims - Chromosomal instability (CIN) is a carcinogenesis event that promotes metastasis and resistance to therapy by unclear mechanisms. Expression of the colon cancer–associated transcript 2 gene (CCAT2), which encodes a long noncoding RNA (lncRNA), associates with CIN, but little is known about how CCAT2 lncRNA regulates this cancer enabling characteristic.<p> <p>Methods - We ...

    • The long noncoding RNA NEAT1 and nuclear paraspeckles are up-regulated by the transcription factor HSF1 in the heat shock response 

      Lellahi, Seyed Mohammad; Rosenlund, Ingrid Arctander; Hedberg, Annica; Kiær, Liv Torill; Mikkola, Ingvild; Knutsen, Erik; Perander, Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-10)
      The long noncoding RNA (lncRNA) <i>NEAT1</i> (nuclear enriched abundant transcript 1) is the architectural component of nuclear paraspeckles, and it has recently gained considerable attention as it is abnormally expressed in pathological conditions such as cancer and neurodegenerative diseases. <i>NEAT1</i> and paraspeckle formation are increased in cells upon exposure to a variety of environmental ...

    • A Long-Term Low-Frequency Hospital Outbreak of KPC-Producing Klebsiella pneumoniae Involving Intergenus Plasmid Diffusion and a Persisting Environmental Reservoir 

      Tofteland, Ståle; Naseer, Mohammed Umaer; Lislevand, Jan Helge; Sundsfjord, Arnfinn; Samuelsen, Ørjan (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Background: To study the molecular characteristics of a long-term, low frequency outbreak of blaKPC-2 in a low prevalence setting involving the hospital environment. Methodology/Principal Findings: KPC-producing bacteria were screened by selective chromogenic agar and Real-Time PCR. The presence of antibiotic resistance genes was ascribed by PCRs and subsequent sequencing, and the KPC-producing isolates ...

    • Long-Term Use of Lipid-Lowering Drugs Slows Progression of Carotid Atherosclerosis The Tromso Study 1994 to 2008 

      Herder, Marit; Arntzen, Kjell Arne; Johnsen, Stein Harald; Eggen, Anne Elise; Mathiesen, Ellisiv B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Data on the effect of lipid-lowering drugs (LLD) on carotid atherosclerosis outside clinical trials are limited. The aim of this study was to determine the effect of LLD on change in carotid intima media thickness and total plaque area in a general population. Subjects were 1532 women and 1442 men who participated in a longitudinal population-based study with ultrasound examination of intima media ...

    • Longitudinal changes in blood biomarkers and their ability to predict type 2 diabetes mellitus—The Tromsø study 

      Allaoui, Giovanni; Rylander, Charlotta; Averina, Maria; Wilsgaard, Tom; Fuskevåg, Ole Martin; Berg, Vivian (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-11)
      Introduction: Identification of individuals at high risk of developing type 2 diabetes mellitus (T2DM) is important for early prevention of the disease. Once T2DM is established, it is difficult to treat and is associated with cardiovascular complications and increased mortality. We aimed to describe pre- and post-diagnostic changes in blood biomarker concentrations over 30 years in individuals ...

    • A Look into the Melting Pot: The mecC-Harboring Region Is a Recombination Hot Spot in Staphylococcus stepanovicii 

      Semmler, Torsten; Harrison, Ewan M.; Lübke-Becker, Antina; Ulrich, Rainer G.; Wieler, Lothar H.; Guenther, Sebastian; Stamm, Ivonne; Hanssen, Anne-Merethe; Holmes, Mark A.; Vincze, Szilvia; Walther, Birgit (Journal article; Tidsskriftartikkel, 2016-01-22)
      INTRODUCTION Horizontal gene transfer (HGT) is an important driver for resistance- and virulence factor accumulation in pathogenic bacteria such as Staphylococcus aureus. METHODS Here, we have investigated the downstream region of the bacterial chromosomal attachment site (attB) for the staphylococcal cassette chromosome mec (SCCmec) element of a commensal mecC-positive Staphylococcus ...

    • Loss of deuterium in faecal solids and by sequestration in reindeer. Effect on doubly labelled water studies. 

      Milne, Eric; Gotaas, Geir; Haggarty, Paul; Tyler, Nicholas J.C. (Journal article; Peer reviewed; Tidsskriftartikkel, 2000)

    • Loss of S100A14 expression at the tumor-invading front correlates with poor differentiation and worse prognosis in oral squamous cell carcinoma 

      Pandey, Sushma; Osman, Tarig Al-Hadi; Sharma, Sunita; Vallenari, Evan Michael; Shahdafar, Aboulghassem; Pun, Chin B.; Gautam, Dej K.; Uhlin-Hansen, Lars; Rikardsen, Oddveig G; Johannessen, Anne Christine; Costea, Daniela Elena; Sapkota, Dipak (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-23)
      <i>Background</i> - We previously showed a tumor‐suppressive function of S100A14 in oral squamous cell carcinoma (OSCC). This study aimed to examine the prognostic significance and differentiation‐related function of S100A14 in OSCC.<p><p> <i>Methods</i> - S100A14 expression was examined in 170 OSCCs from Norwegian and Nepalese populations using immunohistochemistry. Pro‐differentiation function ...

    • Low adiponectin is associated with diastolic dysfunction in women: A cross-sectional study from the Tromsø Study 

      Norvik, Jon Viljar; Schirmer, Henrik; Ytrehus, Kirsti; Jenssen, Trond Geir; Zykova, Svetlana; Eggen, Anne Elise; Eriksen, Bjørn Odvar; Solbu, Marit Dahl (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-14)
      Background: Heart failure with preserved ejection fraction is closely associated with diastolic dysfunction and related to obesity and female sex. We investigated whether adiponectin, an adipocyte-secreted protein hormone with cardioprotective effects, was associated with indices of diastolic dysfunction, and whether the association was sex dependent. <br>Methods: We conducted a cross-sectional ...

    • Low Expression of miR-424-3p is Highly Correlated with Clinical Failure in Prostate Cancer 

      Richardsen, Elin; Andersen, Sigve; Al-Saad, Samer; Rakaee, Mehrdad; Nordby, Yngve; Pedersen, Mona Irene; Ness, Nora; Ingebriktsen, Lise; Fassina, Ambrogio; Tasken, Kristin Austlid; Millls, Ian; Dønnem, Tom; Bremnes, Roy M.; Rasmussen Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-23)
      Prostate cancer (PC) is a highly heterogenous disease and one of the leading causes of mortality in developed countries. Recently, studies have shown that expression of immune checkpoint proteins are directly or indirectly repressed by microRNAs (miRs) in many types of cancers. The great advantages of using miRs based therapy is the capacity of these short transcripts to target multiple molecules ...

    • Low FEV1, smoking history, and obesity are factors associated with oxygen saturation decrease in an adult population cohort 

      Vold, Monica Linea; Aasebø, Ulf; Melbye, Hasse (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Low Sensitivity of the Formol-Ethyl Acetate Sedimentation Concentration Technique in Low-Intensity Schistosoma japonicum Infections 

      Lier, Tore; Wang, TC; Lu, D; Simonsen, Gunnar Skov; Haukland, Hanne H; Haukland, HH; Vennervald, BJ; Johansen, MV (Journal article; Tidsskriftartikkel, 2009)

    • Low Z-4OHtam concentrations are associated with adverse clinical outcome among early stage premenopausal breast cancer patients treated with adjuvant tamoxifen 

      Helland, Thomas; Naume, Bjørn; Hustad, Steinar; Bifulco, Ersilia; Kvaløy, Jan Terje; Sætersdal, Anna Barbro; Synnestvedt, Marit; Lende, Tone Hoel; Gilje, Bjørnar; Mjaaland, Ingvil; Weyde, Kjetil; Blix, Egil Støre; Wiedswang, Gro; Borgen, Elin; Hertz, Daniel Louis; Janssen, Emiel; Mellgren, Gunnar; Søiland, Håvard (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-14)
      Abstract Low steady‐state levels of active tamoxifen metabolites have been associated with inferior treatment outcomes. In this retrospective analysis of 406 estrogen receptor‐positive breast cancer (BC) patients receiving adjuvant tamoxifen as initial treatment, we have associated our previously reported thresholds for the two active metabolites, Z‐endoxifen and Z‐4‐hydroxy‐tamoxifen (Z‐4OHtam), ...

    • LTX-315 sequentially promotes lymphocyte-independent and lymphocyte-dependent antitumor effects 

      Liao, Hsin-Wei; Garris, Christopher; Pfirschke, Christina; Rickelt, Steffen; Arlauckas, Sean; Siwicki, Marie; Kohler, Rainer; Weissleder, Ralph; Sundvold-Gjerstad, Vibeke; Sveinbjørnsson, Baldur; Rekdal, Øystein; Pittet, Mikael J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-14)
      LTX-315 is an oncolytic peptide that has antitumor efficacy in mice grafted with various tumor cell lines and is currently being tested in phase II clinical trials. Here we aimed to further evaluate LTX-315 in conditional genetic mouse models of cancer that typically resist current treatment options and to better understand the drug’s mode of action in vivo. We report LTX-315 mediates profound ...