Blar i tittel Artikler, rapporter og annet (medisinsk biologi)

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    • MicroRNA 141 is associated to outcome and aggressive tumor characteristics in prostate cancer 

      Richardsen, Elin; Andersen, Sigve; Melbø-Jørgensen, Christian; Rakaee, Mehrdad; Ness, Nora; Al-Saad, Samer; Nordby, Yngve; Pedersen, Mona Irene; Dønnem, Tom; Bremnes, Roy M.; Rasmussen Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-23)
      A large number of miRNAs influence key cellular processes involved in prostate tumorigenesis. Previous studies have demonstrated high expression of miRNAs in human prostate cancer (PC) tissues and cell lines. In previous microarray data, we found miR-141 to be upregulated and miR-145 to be downregulated in PC. In this large PC cohort (n = 535), we explored the prognostic role of miR-141 and miR-145 ...

    • MicroRNAs as potential biomarkers in Merkel cell carcinoma 

      Konstantinell, Aelita Gloria Virginia; Coucheron, Dag H; Sveinbjørnsson, Baldur; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-26)
      Merkel cell carcinoma (MCC) is a rare and aggressive type of skin cancer associated with a poor prognosis. This carcinoma was named after its presumed cell of origin, the Merkel cell, which is a mechanoreceptor cell located in the basal epidermal layer of the skin. Merkel cell polyomavirus seems to be the major causal factor for MCC because approximately 80% of all MCCs are positive for viral DNAs. ...

    • MicroRNAs in Daphnia magna identified and characterized by deep sequencing, genome mapping and manual curation 

      Coucheron, Dag H; Wojewodzic, Marcin; Bøhn, Thomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-04)
      MicroRNAs (miRNAs) are small non-coding RNAs that function in RNA silencing and post-transcriptional regulation of gene expression in most organisms. The water flea, <i>Daphnia magna</i> is a key model to study phenotypic, physiological and genomic responses to environmental cues and miRNAs can potentially mediate these responses. By using deep sequencing, genome mapping and manual curations, we ...

    • Midwives’ Adherence to Preoperative Care Guidelines Prior to Emergency Caesarean Section at Bwaila Maternity Hospital in Malawi 

      Mwale, Ruth; Maluwa, Alfred; Malata, Address; Odland, Jon Øyvind (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Mikrobiologisk beredskap: Strategimøte nr 19, 2005 

      Lassen, Jørgen; Sandven, Per; Hjertland, Reidar; Mannsåker, Turid; Myrmel, Helge; Simonsen, Gunnar Skov (Research report; Forskningsrapport, 2005)
      Referansegruppen for programmet ”Eksterne kvalitetsvurderinger i bakteriologi, mykologi og parasittologi” arrangerte 04.11.2005 det 19. strategimøtet for programmets deltagere. Møtets tema var denne gangen ”Mikrobiologisk beredskap”.

    • Mindfulness-Based Stress Reduction for Integrative Cancer Care : a Summary of Evidence 

      Musial, Frauke; Büssing, Arndt; Heusser, Peter; Choi, Kyung-Eun; Ostermann, Thomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      This paper provides a comprehensive overview of the relevant existing evidence, and critically appraises the use of mindfulness-based stress reduction (MBSR) in cancer care. Furthermore, a meta-analysis was conducted in order to investigate the effect of MBSR on quality of life (QoL), mood, and distress. Besides 6 reviews (5 systematic, 1 meta-analytic) which are reported separately, a total of 19 ...

    • miR-101-5p Acts as a Tumor Suppressor in HER2-Positive Breast Cancer Cells and Improves Targeted Therapy 

      Normann, Lisa Svartdal; Haugen, Mads Haugland; Aure, Miriam Ragle; Kristensen, Vessela N.; Mælandsmo, Gunhild Mari; Sahlberg, Kristine Kleivi (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-01)
      Purpose: Human epidermal growth factor receptor 2 positive (HER2+) breast cancers responding poorly to targeted therapy need improved treatment options. miR-101-5p has shown tumor-suppressive properties in multiple cancer forms, and we assessed the effect and mechanism of action of this miRNA in HER2+ breast cancer.<p> <p>Methods: Expression levels of miR-101-5p in two clinical datasets, TCGA and ...

    • MiR-493-5p attenuates the invasiveness and tumorigenicity in human breast cancer by targeting FUT4 

      Zhao, Lifen; Feng, Xiaobin; Song, Xiaobo; Zhou, Humin; Zhao, Yongfu; Cheng, Lei; Jia, Li (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-16)
      Breast cancer is a leading cause of cancer-related mortality among women. Altered fucosylation was found to be closely associated with tumorigenesis and metastasis of breast cancer. MicroRNAs (miRNAs) are important regulators of cell proliferation and metastasis, and aberrant miRNA expression has been observed in breast cancer. The present study aimed to evaluate the level of fucosyltransferase IV ...

    • MiRNAs‐181a/b therapy in lung cancer: reality or myth? 

      Braicu, Cornelia; Gulei, Diana; Cojocneanu, Roxana Maria; Raduly, Lajos; Jurj, Ancuta; Knutsen, Erik; Calin, George Adrian; Berindan-Neagoe, Ioana (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-03)
      Despite substantial progress in oncology, lung cancer remains the number one malignancy in terms of both incidence and mortality rates, and there thus remains an urgent need for new therapeutic alternatives. MicroRNA (miRNA) have an important role in cancer initiation and progression due to their capacity to interfere with transcriptional signaling and regulate key cellular processes. miR‐181a and ...

    • Mitochondrial genome variation of Atlantic cod 

      Jørgensen, Tor Erik; Karlsen, Bård Ove; Emblem, Åse; Breines, Ragna; Andreassen, morten; Rounge, Trine Ballestad; Nederbragt, Alexander Johan; Jakobsen, Kjetill Sigurd; Nymark, Marianne; Ursvik, anita; Coucheron, Dag H; Jakt, Lars Martin; Nordeide, Jarle Tryti; Moum, Truls Borg; Johansen, Steinar Daae (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-19)
      Objective:<br> The objective of this study was to analyse intraspecifc sequence variation of Atlantic cod mitochondrial DNA, based on a comprehensive collection of completely sequenced mitochondrial genomes. <br>Results:<br> We determined the complete mitochondrial DNA sequence of 124 cod specimens from the eastern and western part of the species’ distribution range in the North Atlantic Ocean. ...

    • A mitogenomic approach to the taxonomy of pollocks. Theragra chalcogramma and T. finnmarchica represent one single species 

      Ursvik, Anita; Breines, Ragna; Christiansen, Jørgen Schou; Fevolden, Jan-Erik; Coucheron, Dag H.; Johansen, Steinar D. (Journal article; Tidsskriftartikkel; Peer reviewed, 2007-06-07)
      Background: The walleye pollock (Theragra chalcogramma) and Norwegian pollock (T. finnmarchica) are confined to the North Pacific and North Atlantic Oceans, respectively, and considered as distinct species within the family Gadidae. We have determined the complete mtDNA nucleotide sequence of two specimens of Norwegian pollock and compared the sequences to that of 10 specimens of walleye pollock ...

    • MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy 

      Owyong, Mark; Chou, Jonathan; van den Bijgaart, Renske; Kong, Niwen; Efe, Gizem; Maynard, Carrie; Talmi-Frank, Dalit; Solomonov, Inna; Koopman, Charlotte; Hadler-Olsen, Elin Synnøve; Headley, Mark; Lin, Charlene; Wang, Chih-Yang; Sagi, Irit; Werb, Zena; Plaks, Vicki (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-14)
      Metastasis, the main cause of cancer-related death, has traditionally been viewed as a late-occurring process during cancer progression. Using the MMTV-PyMT luminal B breast cancer model, we demonstrate that the lung metastatic niche is established early during tumorigenesis. We found that matrix metalloproteinase 9 (MMP9) is an important component of the metastatic niche early in tumorigenesis and ...

    • Modelling fatty liver disease with mouse liver-derived multicellular spheroids 

      van Os, Elise Anne; Cools, Laura; Eysackers, Nathalie; Szafranska, Karolina; Smout, Ayla; Verhulst, Stefaan; Reynaert, Hendrik; McCourt, Peter Anthony; Mannaerts, Inge; van Grunsven, Leo A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-28)
      Chronic liver disease can lead to liver fibrosis and ultimately cirrhosis, which is a significant health burden and a major cause of death worldwide. Reliable in vitro models are lacking and thus mono-cultures of cell lines are still used to study liver disease and evaluate candidate anti-fibrotic drugs. We established functional multicellular liver spheroid (MCLS) cultures using primary mouse ...

    • Moderate but not severe hypothermia causes pro-arrhythmic changes in cardiac electrophysiology 

      Dietrichs, Erik Sveberg; McGlynn, Karen; Allan, Andrew; Connolly, Adam; Bishop, Martin; Burton, Francis; Kettlewell, Sarah; Myles, Rachel; Tveita, Torkjel; Smith, Godfrey L (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-07)
      <i>Aims</i> - Treatment of arrhythmias evoked by hypothermia/rewarming remains challenging, and the underlying mechanisms are unclear. This <i>in vitro</i> experimental study assessed cardiac electrophysiology in isolated rabbit hearts at temperatures occurring in therapeutic and accidental hypothermia.<p><p> <i>Methods and results</i> - Detailed ECG, surface electrogram, and panoramic optical ...

    • Modification of sialylation is associated with multidrug resistance in human acute myeloid leukemia 

      Ma, H; Zhou, H; Song, X; Shi, S; Zhang, J; Jia, L (Journal article; Tidsskriftartikkel; Peer reviewed, 2015)

    • Modulation of high affinity ATP-dependent cyclic nucleotide transporters by specific and non-specific cyclic nucleotide phosphodiesterase inhibitors 

      Aronsen, Lena; Ørvoll, Elin Peggy Hanne Øien; Lyså, Roy Andre; Ravna, Aina Westrheim; Sager, Georg (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-11-07)
      Intracellular cyclic nucleotides are eliminated by phosphodiesterases (PDEs) and by ATP Binding cassette transporters such as ABCC4 and ABCC5. PDE5 and ABCC5 have similar affinity for cGMP whereas ABCC5 has much higher affinity for cGMP compared with cAMP. Since the substrate (cGMP) is identical for these two eliminatory processes it is conceivable that various PDE inhibitors also modulate ...

    • Modulation of Plasma Membrane Composition and Microdomain Organization Impairs Heat Shock Protein Expression in B16-F10 Mouse Melanoma Cells 

      Crul, Tim; Csoboz, Balint; Gombos, Imre; Marton, Annamaria; Peter, Maria; Balogh, Gabor; Vizler, Csaba; Szente, Lajos; Vigh, Laszlo (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-12)
      The heat shock response (HSR) regulates induction of stress/heat shock proteins (HSPs) to preserve proteostasis during cellular stress. Earlier, our group established that the plasma membrane (PM) acts as a sensor and regulator of HSR through changes in its microdomain organization. PM microdomains such as lipid rafts, dynamic nanoscale assemblies enriched in cholesterol and sphingomyelin, and ...

    • Molecular and epidemiological characterization of carbapenemase-producing Enterobacteriaceae in Norway, 2007 to 2014 

      Samuelsen, Ørjan; Overballe-Petersen, Søren; Bjørnholt, Jørgen; Brisse, Sylvain; Doumith, Michel; Woodford, Neil; Hopkins, Katie L.; Aasnæs, Bettina; Haldorsen, Bjørg; Sundsfjord, Arnfinn (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-15)
      The prevalence of carbapenemase-producing Enterobacteriaceae (CPE) is increasing worldwide. Here we present associated patient data and molecular, epidemiological and phenotypic characteristics of all CPE isolates in Norway from 2007 to 2014 confirmed at the Norwegian National Advisory Unit on Detection of Antimicrobial Resistance. All confirmed CPE isolates were characterized pheno- and genotypically, ...

    • Molecular characterization and phylogenetics of Fennoscandian cowpox virus isolates based on the p4c and atip genes 

      Okeke, Malachy Ifeanyi; Okoli, Arinze Stanley; Nilssen, Øivind; Moens, Ugo; Tryland, Morten; Bøhn, Thomas; Traavik, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
      Background: Cowpox virus (CPXV), a rodent-borne Orthopoxvirus (OPV) that is indigenous to Eurasia can infect humans, cattle, felidae and other animals. Molecular characterization of CPXVs isolated from different geographic locations is important for the understanding of their biology, geographic distribution, classification and evolution. Our aim was to characterize CPXVs isolated from Fennoscandia ...

    • Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins 

      Wirth, Martina; Zhang, Wenxin; Razi, Minoo; Nyoni, Lynet; Joshi, Dhira; O'Reilly, Nicola; Johansen, Terje; Tooze, Sharon; Mouilleron, Stephane (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-03)
      Autophagy is an essential recycling and quality control pathway. Mammalian ATG8 proteins drive autophagosome formation and selective removal of protein aggregates and organelles by recruiting autophagy receptors and adaptors that contain a LC3-interacting region (LIR) motif. LIR motifs can be highly selective for ATG8 subfamily proteins (LC3s/GABARAPs), however the molecular determinants regulating ...