Blar i tittel Artikler, rapporter og annet (klinisk medisin)
Viser treff 208-227 av 1796
-
The cardiac impact of cisplatin-based chemotherapy in survivors of testicular cancer: A 30-year follow-up
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-05)Aims - Cisplatin-based chemotherapy (CBCT) is essential in the treatment of metastatic testicular cancer (TC) but has been associated with long-term risk of cardiovascular morbidity and mortality. Furthermore, cisplatin can be detected in the body decades after treatment. We aimed to evaluate the long-term impact of CBCT on cardiac function and morphology in TC survivors 30 years after treatment.< ... -
Cardiorespiratory fitness and future risk of venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-25)<i>Background</i> - Cardiorespiratory fitness (CRF) is a strong predictor of future arterial cardiovascular disease and premature mortality. However, there are limited data on the association between CRF and the risk of incident venous thromboembolism (VTE).<p><p> <i>Objectives</i> - To investigate whether estimated CRF (eCRF) was associated with the risk of incident VTE in a cohort recruited ... -
Cardiovascular Effects of Epinephrine During Experimental Hypothermia (32°C) With Spontaneous Circulation in an Intact Porcine Model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-06)<i>Aims</i>: Rewarming from accidental hypothermia and therapeutic temperature management could be complicated by cardiac dysfunction. Although pharmacologic support is often applied when rewarming these patients, updated treatment recommendations are lacking. There is an underlying deficiency of clinical and experimental data to support such interventions and this prevents the development of clinical ... -
Carers’ experiences with overnight respite care : a qualitative study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2009)Aim: The aim of this study was to explore experiences with overnight respite care (ORC) of Norwegian carers who provided care to frail elderly awaiting nursing home placement. <br> Background: In many Western countries respite care has become part of health care service provision, and various types of respite care are available. The intent with respite care can be twofold; caring for the care ... -
Cartilage Repair and Joint Preservation Medical and Surgical Treatment Options
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)Articular cartilage defects are most often caused by trauma and osteoarthritis and less commonly by metabolic disorders of the subchondral bone, such as osteonecrosis and osteochondritis dissecans. Such defects do not heal spontaneously in adults and can lead to secondary osteoarthritis. Medications are indicated for symptomatic relief. Slow-acting drugs in osteo - arthritis (SADOA), such as ... -
Cause-specific excess mortality after hip fracture: the Norwegian Epidemiologic Osteoporosis Studies (NOREPOS)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-31)Background Information on cause of death may help appraise the degree to which the high excess mortality after hip fracture refects pre-existing comorbidities or the injury itself. We aimed to describe causes of death and causespecifc excess mortality through the frst year after hip fracture.<p> <p>Methods For studying the distribution of causes of death by time after hip fracture, we calculated ... -
CD14 and complement crosstalk and largely mediate the transcriptional response to Escherichia coli in human whole blood as revealed by DNA microarray
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-23)Systemic inflammation like in sepsis is still lacking specific diagnostic markers and effective therapeutics. The first line of defense against intruding pathogens and endogenous damage signals is pattern recognition by e.g., complement and Toll-like receptors (TLR). Combined inhibition of a key complement component (C3 and C5) and TLR-co-receptor CD14 has been shown to attenuate certain systemic ... -
CD4 cell count and CD4/CD8 ratio increase during rituximab maintenance in Granulomatosis with polyangiitis patients
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-20)<b>Introduction</b> <br> Rituximab (RTX) is a B cell-depleting agent approved for the treatment of granulomatosis with polyangiitis (GPA). RTX reduces antibody producing precursor plasma cells and inhibits B and T cells interaction. Infections related to T cell immunodeficiency are not infrequent during RTX treatment. Our study investigated CD4 cell count and CD4/CD8 ratio in GPA patients during the ... -
CD4/CD8 co-expression shows independent prognostic impact in resected non-small cell lung cancer patients treated with adjuvant radiotherapy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013) -
Cellular and molecular mediators of intestinal fibrosis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11-02)Intestinal fibrosis is a major complication of the inflammatory bowel diseases (IBD) and although inflammation is necessary for its development, it would appear that it plays a minor role in its progression as anti-inflammatory treatments in IBD do not prevent fibrosis once it has started. The processes that regulate fibrosis would thus appear to be distinct from those regulating inflammation and, ... -
Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-10)<p><i>Background - </i>Obesity is a risk factor for end-stage renal disease. Renal hyperfiltration, defined as an abnormally high glomerular filtration rate (GFR), is a link in the causal chain between diabetes and chronic kidney disease. Whether obesity is associated with hyperfiltration in the non-diabetic general population, remains unresolved due to a lack of consensus regarding the definition ... -
Centralizing a national pancreatoduodenectomy service: striking the right balance
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-07)<i>Background</i> - Centralization of pancreatic surgery is currently called for owing to superior outcomes in higher‐volume centres. Conversely, organizational and patient concerns speak for a moderation in centralization. Consensus on the optimal balance has not yet been reached. This observational study presents a volume–outcome analysis of a complete national cohort in a health system with ... -
Centre and Periphery of Nano : a Norwegian Context
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)This work describes the nano field inNorway as currently emerging in the dynamics between two forms of nano research activities described along a centre-periphery axis. 1) There are strategic research initiatives committed to redeem the envisioned potential of the field by means of social and material reorganisation of existing research activities. This activity is seen as central as it is one of ... -
Cerebral aneurysm morphology before and after rupture: nation-wide case series of 29 aneurysms
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-06)<p><i>Background and Purpose</i>: Using postrupture morphology to predict rupture risk of an intracranial aneurysm may be inaccurate because of possible morphological changes at or around the time of rupture. The present study aims at comparing morphology from angiograms obtained prior to and just after rupture and to evaluate whether postrupture morphology is an adequate surrogate for rupture ... -
Cerebral blood flow measurements with 15O-water PET using a non-invasive machine-learning-derived arterial input function
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-08)<p>Cerebral blood flow (CBF) can be measured with dynamic positron emission tomography (PET) of <sup>15</sup>O-labeled water by using tracer kinetic modelling. However, for quantification of regional CBF, an arterial input function (AIF), obtained from arterial blood sampling, is required. In this work we evaluated a novel, non-invasive approach for input function prediction based on machine learning ... -
Cerebroplacental ratio in predicting adverse perinatal outcome: a meta-analysis of individual participant data
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-03)Objective To investigate if cerebroplacental ratio (CPR) adds to the predictive value of umbilical artery pulsatility index (UA PI) alone – standard of practice – for adverse perinatal outcome in singleton pregnancies.<p> <p>Design and setting Meta-analysis based on individual participant data (IPD).<p> <p>Population or sample Ten centres provided 17 data sets for 21 661 participants, 18 731 ... -
Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis: 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-09)Background - The optimal first-line treatment in early rheumatoid arthritis (RA) is debated. We compared clinical and radiographic outcomes of active conventional therapy with each of three biological treatments with different modes of action.<p> <p>Methods - Investigator-initiated, randomised, blinded-assessor study. Patients with treatment-naïve early RA with moderate–severe disease activity ... -
Cervical spine surgery in the Northern Norway Regional Health Authority area in 2014-18
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-24)<p>BAKGRUNN - Kunnskap om variasjon i behandlingsrater er nødvendig for å vurdere om tilgangen til helsetjenester er likeverdig. Formålet med denne studien var å undersøke rater for kirurgisk behandling av degenerative nakkelidelser i Norge og Helse Nord, samt egendekningen i Helse Nord, og å vurdere aktiviteten i regionen. <p>MATERIALE OG METODE - Vi inkluderte operasjoner registrert i Norsk ... -
The challenge of durable brain control in patients with brain-only metastases from breast cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10-07)The vast majority of patients with brain metastases from breast cancer have extracranial metastases, e.g., in the liver, lungs or bones, with serious impact on prognosis. Limited research has been performed on patients with brain-only disease. We analyzed patterns of treatment, brain control and survival in uni- and multivariate analyses. All 25 patients with brain-only disease were treated with ... -
Change characteristics of health-related quality of life and its association with post-stroke fatigue at four-year follow-up
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-04)The long-term consequences of stroke may be highly individual and multifaceted. The question of how such individual differences may unfold and change beyond the first year after stroke may be of substantial clinical interest regarding which subgroups show more favourable and unfavourable rehabilitation trajectories. The current study explored functional trajectories from 1 to 4 years post-stroke ...