Artikler, rapporter og annet (klinisk medisin): Recent submissions

Now showing items 1921-1940 of 1974

    • Asialoglycoprotein Receptor (ASGP-R) is Liver Parenchymal Cells is Involved in Elimination of Recombinant Human TFPI 

      Appa, Rupa Shree; Øie, Cristina Ionica; Brodin, Ellen; Hansen, John-Bjarne; Smedsrød, Bård (Journal article; Tidsskriftartikkel, 2010)
      We here report on a study carried out to determine the early clearance kinetics, and organ, cell(s) and receptor(s) responsible for the clearance of full length TFPI purified from BHK cells (TFPI<sup>BHK</sup>). Following intravenous administration, <sup>125</sup>I-TFPI<sup>BHK</sup> was cleared with a biphasic elimination curve, and with a significantly slower t<sub>1/2</sub>α compared to recombinant ...

    • Increased sinusoidal flow is not the primary stimulus to liver regeneration 

      Mortensen, Kim Erlend; Conley, Lene N.; Sorenesen, Peter; Nygaard, Ingvild; Mortensen, Elin; Bendixen, Christian; Revhaug, Arthur (Journal article; Tidsskriftartikkel; Peer reviewed, 2010-01-20)
      Background: Hemodynamic changes in the liver remnant following partial hepatectomy (PHx) have been suggested to be a primary stimulus in triggering liver regeneration. We hypothesized that it is the increased sinusoidal flow per se and hence the shear-stress stimulus on the endothelial surface within the liver remnant which is the main stimulus to regeneration. In order to test this hypothesis we ...

    • Kinship care for the safety, permanency, and well-being of children removed from the home for maltreatment 

      Winokur, Marc; Holtan, Amy; Valentine, D (Journal article; Tidsskriftartikkel; Peer reviewed, 2009-01-21)
      Every year a large number of children around the world are removed from their homes because they are maltreated. Child welfare agencies are responsible for placing these children in out-of-home settings that will facilitate their safety, permanency, and well-being. However, children in out-of-home placements typically display more educational, behavioral, and psychological problems than do their ...

    • Armoda er ikkje sjølvforskyldt 

      Elstad, Ingunn (Chapter; Bokkapittel, 2007)

    • Prognostic Impact of Fibroblast Growth Factor 2 in NSCLC : Co-Expression with VEGFR-3 and PDGF-B Predicts Poor Survival 

      Dønnem, Tom; Al-Shibli, Khalid; Al-Saad, Samer; Busund, Lill-Tove; Bremnes, Roy M. (Tidsskriftartikkel; Peer reviewed; Journal article, 2009-05)
      Purpose: Fibroblast growth factor 2 (FGF2; basic fibroblast growth factor, b-FGF) and its main receptor FGFR-1 are important in both hemangiogenesis and lymphangiogenesis. Murine studies have indicated a close interplay between both FGF2 and platelet-derived growth factor –B (PDGF-B) as well as FGF2 and vascular endothelial growth factor -3 (VEGFR-3). This study investigates the prognostic impact ...

    • Does chemotherapy improve Quality of Life in NSCLC PS 2? 

      Helbekkmo, Nina; Sundstrøm, Stein H.; von Plessen, Christian; Strøm, Hans H.; Aasebø, Ulf; Bremnes, Roy M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2009-03)
      Introduction <br>Nearly 40% of patients with advanced NSCLC are in performance status (PS) 2. These patients have a shorter life expectancy than PS 0/1 patients and they are underrepresented in clinical trials. Data on how platinum-based combination chemotherapy affects Health Related Quality of Life (HRQOL) of patients with PS 2 are scarce and the treatment of this important group of patients is ...

    • The relation between serum parathyroid hormone (PTH) and blood pressure. The Tromsø study 

      Jorde, Rolf (Journal article; Tidsskriftartikkel, 2006)
      The objective of the present cross-sectional epidemiological study from Tromsø, North Norway was to evaluate the relation between blood pressure and serum parathyroid hormone (PTH). 10419 subjects were invited to participate in the fifth Tromsø study and 8128 attended. 7954 subjects had serum PTH measured, and among these, information on blood pressure medication was available in 5841 subjects (2554 ...

    • Ultrasound imaging of carotid atherosclerosis in a normal population. The Tromsø Study 

      Johnsen, Stein Harald; Mathiesen, Ellisiv B. (Journal article; Tidsskriftartikkel, 2009)
      In the Tromsø study, we have successfully used high resolution ultrasonography for assessing atherosclerosis development in a general population. The method is well suited for large epidemiological surveys. Methodological problems could be overcome by using highly standardized protocols, pre-study training of sonographers and readers, and off-line computer-based batch reading of digitized images. ...

    • Welfare and labour-force participation of kinship foster mothers 

      Holtan, Amy; Thørnblad, Renee (Journal article; Tidsskriftartikkel, 2009)
      Objective: Kinship foster care has become the placement of choice in the Western world. This article explores the welfare, labour-force participation, and caregiving role of kinship foster mothers in Norway. <br>Method: The study supplements a quantitative study of Norwegian long-term kinship and nonkinship foster care with a qualitative study of parenting in formal kinship foster care. A total of ...

    • Selvmordsforebyggende arbeid : fagfolks forståelse av kyndig praksis 

      Jessen, Pia Birgitte; Holtan, Amy (Journal article; Tidsskriftartikkel; Peer reviewed, 2009)

    • HLA-B27 predicts a more extended disease with increasing age at onset in boys with juvenile idiopathic arthritis 

      Nordal, Ellen Berit; Berntson, L.; Damgård, M.; Andersson-Gäre, B.; Herlin, T.; Nielsen, S.; Rygg, M.; Zak, M.; Fasth, A. (Conference object; Konferansebidrag, 2008-09-15)

    • Refleksjon og læring i et aksjonsrettet fagutviklingsprosjekt : erfaringer fra et samarbeid mellom studenter, praksisveiledere og lærere i et nytt, fleksibelt utdanningsforløp i fysioterapi 

      Aars, Marianne (Research report; Forskningsrapport, 2006)
      Denne rapporten er basert på er et aksjonsrettet prosjekt som har involvert et (ut)forskende partnerskap mellom tre studenter, fem praksisveiledere og to lærere. Vi har hatt studentenes læring i fokus og fulgt ulike læringsaktiviteter på ulike læringsarenaer over en periode på 5 mnd. Det har vært lærerikt for oss alle. Vi har reflektert over studenters læring og gjennom det: over vår egen ...

    • Incidence of hospital referred head injuries in Norway : a population based survey from the Stavanger region 

      Romner, Bertil; Heskestad, Ben; Baardsen, Roald; Ingebrigtsen, Tor; Helseth, Eirik; Waterloo, Knut (Journal article; Tidsskriftartikkel; Peer reviewed, 2009-02-20)
      Background: In three previous Norwegian studies conducted between 1974 and 1993, the annual incidence rates of hospital admitted head injuries were 236, 200 and 169 per 100,000 population. The aim of this study was to describe the incidence of head injury in the Stavanger region and to compare it with previous Norwegian studies. <br> Methods: All head injured patients referred to Stavanger ...

    • Decentralization matters - Differently organized mental health services relationship to staff competence and treatment practice : the VELO study 

      Olstad, Reidun; Bjorbekkmo, Svein; Myklebust, Lars H.; Sørgaard, Knut; Molvik, Stian; Nymann, Asle (Journal article; Tidsskriftartikkel; Peer reviewed, 2009-05-18)
      Background: The VELO study is a comparative study of two Community Mental Health Centres (CMHC) in Northern Norway. The CMHCs are organized differently: one has no local inpatient unit, the other has three. Both CMHCs use the Central Mental Hospital situated rather far away for compulsory and other admissions, but one uses mainly local beds while the other uses only central hospital beds. In ...

    • In vitro host range, multiplication and virion forms of recombinant viruses obtained from co-infection in vitro with a vaccinia-vectored influenza vaccine and a naturally occurring cowpox virus isolate 

      Tryland, Morten; Okeke, Malachy Ifeanyi; Nilssen, Øivind; Moens, Ugo; Traavik, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2009-05-12)
      Background: Poxvirus-vectored vaccines against infectious diseases and cancer are currently under development. We hypothesized that the extensive use of poxvirus-vectored vaccine in future might result in co-infection and recombination between the vaccine virus and naturally occurring poxviruses, resulting in hybrid viruses with unpredictable characteristics. Previously, we confirmed that ...

    • Prognostic scores in brain metastases from breast cancer 

      Nieder, Carsten; Marienhagen, Kirsten; Astner, Sabrina T.; Molls, Michael (Journal article; Tidsskriftartikkel; Peer reviewed, 2009-04-07)
      Background: Prognostic scores might be useful tools both in clinical practice and clinical trials, where they can be used as stratification parameter. The available scores for patients with brain metastases have never been tested specifically in patients with primary breast cancer. It is therefore unknown which score is most appropriate for these patients. <br> Methods: Five previously published ...

    • Prognostic indices for brain metastases : usefulness and challenges 

      Nieder, Carsten; Mehta, Minesh P. (Journal article; Peer reviewed; Tidsskriftartikkel, 2009-03-04)
      Background: This review addresses the strengths and weaknesses of 6 different prognostic indices, published since the Radiation Therapy Oncology Group (RTOG) developed and validated the widely used 3-tiered prognostic index known as recursive partitioning analysis (RPA) classes, i.e. between 1997 and 2008. In addition, other analyses of prognostic factors in groups of patients, which typically ...

    • Parathyroid hormone, but not vitamin D, is associated with the metabolic syndrome in morbidly obese women and men : a cross-sectional study 

      Hjelmesæth, Jøran; Hofsø, Dag; Aasheim, Erlend T.; Jenssen, Trond Geir; Moan, Johan; Hager, Helle; Røislien, Jo; Bollerslev, Jens (Journal article; Tidsskriftartikkel; Peer reviewed, 2009-02-03)
      Background: The prevalence of vitamin D insufficiency and secondary hyperparathyroidism is high among morbidly obese subjects. Further, low serum levels of 25-hydroxyvitamin D (25 [OH]D) and magnesium have been associated with increased risk of the metabolic syndrome (MS), and recently, a possible link between PTH and MS has been reported. Although it is well known that the synthesis and secretion ...

    • Evaluation of the medical student research programme in Norwegian medical schools : a survey of students and supervisors 

      Hansen, John-Bjarne; Hunskaar, Steinar; Breivik, Jarle; Figenschau, Kristian; Siebke, Maje; Tømmerås, Karin (Journal article; Tidsskriftartikkel; Peer reviewed, 2009-07-14)
      Background: The Medical Student Research Programme is a national education and grant scheme for medical students who wish to carry out research in parallel with their studies. The purpose of the programme is to increase recruitment of people with a standard medical degree to medical research. The Research Programme was established in 2002 and underwent a thorough evaluation during the spring of ...

    • Recombinant human activated protein C attenuates endotoxin-induced lung injury in awake sheep 

      Wærhaug, Kristine; Langbakk, Bodil; Kuklin, Vladimir N.; Kirov, Mikhail Y.; Sovershaev, Mikhail; Ingebretsen, Ole C.; Ytrehus, Kirsti; Bjertnæs, Lars J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-08-15)
      Introduction: Acute lung injury often complicates severe sepsis. In Gram-negative sepsis, bacterial endotoxin activates both coagulation and inflammation. Enhanced lung vascular pressures and permeability, increased extravascular lung water content and deteriorated gas exchange characterize ovine endotoxin-induced lung injury, a frequently used model of acute lung injury. Recombinant human ...