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norskBrowsing Artikler, rapporter og annet (farmasi) by Title
Now showing items 84-103 of 358
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Development of a biomimetic phospholipid vesicle-based permeation assay for the estimation of intestinal drug permeability
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Development of a novel beta-glucan supplemented hydrogel spray formulation and wound healing efficacy in a db/db diabetic mouse model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-30)To relieve the severe economic and social burdens and patient suffering caused by the increasing incidence of chronic wounds, more effective treatments are urgently needed. In this study, we focused on developing a novel sprayable wound dressing with the active ingredient β-1,3/1,6-glucan (βG). Since βG is already available as the active ingredient in a commercial wound healing product provided as ... -
Differential in vivo tumorigenicity of distinct subpopulations from a luminal-like breast cancer xenograft
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Direct and indirect risk associated with the use of dietary supplements among persons with dementia in a Norwegian memory clinic
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-12)Background: The use of dietary supplements (DS) is common among persons with dementia. Direct risks associated with DS use include adverse events and DS-drug interactions. A direct risk is a risk caused by the treatment itself. Indirect risks are related to the treatment setting, such as the conditions of use, and not to the treatment itself. Because dementia symptoms may reduce a person’s ability ... -
Direct small RNA signatures in extracellular vesicles from breast cancer cell lines
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-31)Breast cancer is a heterogeneous disease, and different subtypes of breast cancer show distinct cellular morphology, gene expression, metabolism, motility, proliferation, and metastatic potential. Understanding the molecular features responsible for this heterogeneity is important for correct diagnosis and better treatment strategies. Extracellular vesicles (EVs) and their associated molecules ... -
Dissemination and Characteristics of a Novel Plasmid-Encoded Carbapenem-Hydrolyzing Class D β-Lactamase, OXA-436, Found in Isolates from Four Patients Involving Six Different Hospitals in Denmark.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-23)The diversity of OXA-48-like carbapenemases are continually expanding. In this study, we describe the dissemination and characteristics of a novel class D carbapenemase (CHDL) named OXA-436. In total, six OXA-436-producing Enterobacteriaceae isolates including Enterobacter asburiae (n=3), Citrobacter freundii (n=2) and Klebsiella pneumoniae (n=1) were identified in four patients in the period between ... -
Docetaxel Liposomes - A formulation Screening Study
(Conference object; Konferansebidrag, 2019)<p>Docetaxel (DOC) is a potent anticancer drug with several limitations, including poor solubility and the reported serious side effects, attributed to either the drug itself or the solvent used. Thus, it is interesting to entrap the drug into liposomes in order to solubilize the drug and improve the therapeutic outcome. <p>The fist aim of this study was to establish a small-scale screening method ... -
Dominance between plasmids determines the extent of biofilm formation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-26)Bacterial biofilms have an impact in medical and industrial environments because they often confer protection to bacteria against harmful agents, and constitute a source from which microorganisms can disperse. Conjugative plasmids can enhance bacterial ability to form biofilms because conjugative pili act as adhesion factors. However, plasmids may interact with each other, either facilitating or ... -
Drug loading to mesoporous silica carriers by solvent evaporation: A comparative study of amorphization capacity and release kinetics
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-08)The sorption of poorly aqueous soluble active pharmaceutical ingredients (API) to mesoporous silica carriers is an increasingly common formulation strategy for dissolution rate enhancement for this challenging group of substances. However, the success of this approach for a particular API depends on an array of factors including the properties of the porous carrier, the loading method, or the attempted ... -
Drug permeability across a phospholipid vesicle based barrier: 3. Characterization of drug-membrane interactions and the effect of agitation on the barrier integrity and on the permeability
(Journal article; Tidsskriftartikkel; Peer reviewed, 2007)Recently, we reported on the development and structural characterization of a phospholipid vesicle based barrier useful for medium throughput screening of passive drug permeability. Here, we investigate the physical and functional integrity of the phospholipid vesicle based barriers to agitation by stirring or shaking, and whether agitation affects drug permeability of sulpiride, metoprolol and ... -
Drug permeability across a phospholipid vesicle based barrier: A novel approach for studying passive diffusion
(Journal article; Tidsskriftartikkel; Peer reviewed, 2005-10)The aim of this study was to develop a novel predictive medium-throughput screening method for drug permeability, with use of a tight barrier of liposomes on a filter support. To our knowledge no one has succeeded in depositing membrane barriers without the use of inert solvent such as hexadecane. The first part of the study involved development of a protocol for preparation of these barriers, which ... -
Drug permeability across a phospholipid vesicle-based barrier - 2. Characterization of barrier structure, storage stability and stability towards pH changes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006-04-18)Recently we reported on the development of a phospholipid vesicle-based barrier as a medium throughput method for screening of drug permeability. The aim of this present study is to characterize the barrier structure, including an estimation of the amount of phospholipid within it, its storage stability and its stability over various pH ranges found in different parts of the gastrointestinal tract. ... -
Drug permeability across a phospholipid vesicle-based barrier: 4. The effect of tensides, co-solvent and pH changes on barrier integrity and on drug permeability
(Journal article; Tidsskriftartikkel; Peer reviewed, 2008-07-03)In this study the integrity of the recently developed phospholipid vesicle-based permeability barrier in the presence of a variety of co-solvents and tensides has been investigated. Also included are studies of the influence of these additives on drug permeation and the effect of pH changes on the permeability of ionogenic drug compounds. Permeability experiments using the hydrophilic model ... -
Drug permeability profiling using cell-free permeation tools: Overview and applications
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-13)Cell-free permeation systems are gaining interest in drug discovery and development as tools to obtain a reliable prediction of passive intestinal absorption without the disadvantages associated with cell- or tissue-based permeability profiling. Depending on the composition of the barrier, cell-free permeation systems are classified into two classes including (i) biomimetic barriers which are ... -
Drug-Drug-Gene Interactions: A Call for Clinical Consideration
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-18)It is widely accepted that both comedications and genetic factors may contribute to variation of drug response. Clinical decision support systems increasingly consider recommendations on drug– drug interactions (DDIs) during electronic prescribing, and some guidelines on drug–gene-interactions (DGI) have been implemented in drug labels. Potentially synergistically or antagonistically ... -
Drug-target binding quantitatively predicts optimal antibiotic dose levels in quinolones
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-14)Antibiotic resistance is rising and we urgently need to gain a better quantitative understanding of how antibiotics act, which in turn would also speed up the development of new antibiotics. Here, we describe a computational model (COMBAT-COmputational Model of Bacterial Antibiotic Target-binding) that can quantitatively predict antibiotic dose-response relationships. Our goal is dual: We address a ... -
Dual-specificity MAP kinase phosphatases in health and disease
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-08)It is well established that a family of dual-specificity MAP kinase phosphatases (MKPs) play key roles in the regulated dephosphorylation and inactivation of MAP kinase isoforms in mammalian cells and tissues. MKPs provide a mechanism of spatiotemporal feedback control of these key signalling pathways, but can also mediate crosstalk between distinct MAP kinase cascades and facilitate interactions ... -
Dyes in Disguise: characterization of fluorescently labeled liposomes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-09)The rather limited success of translation from basic research to clinical application has been highlighted as a major issue in the nanomedicine field. To identify the factors influencing the applicability of nanosystems as drug carriers and potential nanomedicine, we focused on following their fate through fluorescence-based assays, namely flow cytometry and imaging. These methods are often used to ... -
Early response evaluation by single cell signaling profiling in acute myeloid leukemia
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-07)Aberrant pro-survival signaling is a hallmark of cancer cells, but the response to chemotherapy is poorly understood. In this study, we investigate the initial signaling response to standard induction chemotherapy in a cohort of 32 acute myeloid leukemia (AML) patients, using 36-dimensional mass cytometry. Through supervised and unsupervised machine learning approaches, we find that reduction of ... -
Effect of antiangiogenic therapy on tumor growth, vasculature and kinase activity in basal- and luminal-like breast cancer xenografts
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012-03-31)Several clinical trials have investigated the efficacy of bevacizumab in breast cancer, and even if growth inhibiting effects have been registered when antiangiogenic treatment is given in combination with chemotherapy no gain in overall survival has been observed. One reason for the lack of overall survival benefit might be that appropriate criteria for selection of patients likely to respond ...
