Venous thromboembolism (VTE), encompassing both deep vein thrombosis and pulmonary embolism, is a major public health concern due to substantial morbidity and mortality. Around half of all VTE cases are hospital-related. Importantly, VTE also has life-long implications, as a large proportion of VTE-patients suffer either a recurrent event or chronic complications. The first aim of the thesis was to ...

Within the literature, different playing positions present different external load profiles in match-play and are associated with the individual variation in activity profiles. In contrast to detailed information regarding matches, few studies have focused on the training practices in football. Therefore, the aim of this thesis is to assess the levels of specificity that different playing-positions ...

Individuals in industrialized countries spend a substantial part of life in the non-fasting, postprandial state, which is also associated with increased oxidation and inflammation. Furthermore, a high body mass index (BMI) is the third cause of mortality in the world. In this PhD thesis, obese (BMI>30) individuals with and without metabolic disease (n=50) was included, in addition to a normal ...

The brain as a drug target site remains a pharmaceutical challenge in spite of numerous efforts to enhance drug delivery to the brain. Nasal drug administration has gained interest among researchers, especially in the last decade, as it provides direct drug access into the brain. However, the nasal mucus and the surrounding environment often limit the use of nose as the administration site. Drug ...

Detecting signs of disorder from listening to spoken words is a core method in psychiatry. Traditionally the interpretation of speech depends on inherently subjective processes. By contrast, digital technology can be leveraged to detect and analyze what words are spoken, timestamp when they are uttered and quantify the manner in which they are expressed. With the use of mobile communication technology, ...

<p>The tumor microenvironment is a dynamic, constantly evolving interplay between tumor cells, immune cells, endothelial and other stromal cells, and the extracellular matrix. Inflammation is an essential part of the immune system’s response against malignant growth but also a powerful pro-tumorigenic factor as cancer cells can hijack inflammatory mediators to support tumor growth. Neuroblastoma is ...

<p>The gamma-amino-butyric-acid (GABA) is the main inhibitory neurotransmitter in the central nervous system (CNS) and exerts its physiological role by binding to the ionotropic GABA_A and GABA_C receptors and the metabotropic GABA_B receptor (GABA_B-R). The GABA_B-R is an obligate heterodimer that belongs to class C of guanine-binding proteins ...

The complement and coagulation systems are two interrelated plasma protein cascades. Evidence from observational and animal studies has proposed a role for the complement system in the development of venous thromboembolism (VTE), but the exact mechanisms remain obscure. The aim of this thesis was to investigate whether activation of the complement system impacts the risk of VTE and to investigate ...

Ektopisk erupsjon av overkjevens hjørnetenner berører 1-5 prosent av barn, og er en tilstand som kan føre til alvorlige skader på nabotenner samt omfattende tannbehandling. Det vitenskapelige grunnlaget for behandling av ektopiske hjørnetenner er begrenset. Målet med denne PhD-avhandlingen var å skaffe ny kunnskap om omfanget av rotresorpsjon på overkjevens fortenner, den vanligste bivirkningen, ...

This study is part of the national research-based evaluation of the 12 first assertive community treatment (ACT) teams in Norway. ACT is a model for multidisciplinary community-based treatment teams that aim to provide a full range of medical, psychosocial and rehabilitation services to people with severe mental illness. Over 30% of the patients treated in the ACT teams were subject to community ...