Blar i tittel Artikler, rapporter og annet (medisinsk biologi)

Viser treff 662-681 av 1054

    • No Effect of Calanus Oil on Maximal Oxygen Uptake in Healthy Participants: A Randomized Controlled Study 

      Tauschek, Lucas Christian; Røsbjørgen, Ragnhild; Dalen, Håvard; Larsen, Terje; Karlsen, Trine (Journal article; Tidsskriftartikkel, 2022-08-23)
      We aimed to investigate the long-term effect of daily Calanus oil supplementation on maximal oxygen uptake (VO<sub>2</sub>max) in healthy 30- to 50-year-old participants. The study was motivated by preclinical studies reporting increased VO<sub>2</sub>max and metabolic health with omega-3 rich Calanus oil. In a double-blinded study, 71 participants were randomized to receive 2 g/day of Calanus or ...

    • NORM/NORM-VET 2016 - Usage of Antimicrobial Agents and Occurrence of Antimicrobial Resistance in Norway 

      Simonsen, Gunnar Skov; Urdahl, Anne Margrete (Research report; Forskningsrapport, 2017)
      Antimicrobial resistance is an emerging problem worldwide. It reduces the effectiveness of antimicrobial treatment of infectious diseases in humans and animals thereby leading to increased morbidity and mortality, as well as higher costs. It is well established that there is a strong association between the usage of antimicrobial agents and the occurrence of resistance, The selective pressure exerted ...

    • NORM/NORM-VET 2020 

      Simonsen, Gunnar Skov; Blix, Hege Salvesen; Grave, Kari; Urdahl, Anne Margrete (Research report; Forskningsrapport, 2021)

    • NORM/NORM-VET 2021: Usage of Antimicrobial Agents and Occurrence of Antimicrobial Resistance in Norway 

      Akselsen, Per Espen; Andersen, Cecilie Torp; Caugant, Dominique Andree Yvette; Dansie, Live Storehagen; Elstrøm, Petter (Research report; Forskningsrapport, 2022)
      Veterinærinstituttet overvåker forekomst av antibiotikaresistens i mikrober fra fôr, dyr og næringsmidler på oppdrag fra Mattilsynet. Dette gjøres i regi av NORM-VET, som er forkortelse for «Norsk overvåkingsprogram for antibiotikaresistens i mikrober fra fôr, dyr og næringsmidler». Data fra NORM-VET publiseres i den årlige NORM/NORM-VET rapporten som presenterer data om forekomst av antibiotikaresistens ...

    • Normalization of disrupted clock gene expression in males with tetraplegia: a crossover randomized placebo-controlled trial of melatonin supplementation 

      Kostovski, Emil; Frigato, E; Savikj, Mladen; Dahm, Anders Erik A; Sandset, Per Morten; Mowinckel, Marie-Christine; Skretting, Grethe; Østerud, Bjarne; Bertolucci, C; Iversen, Per Ole (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-09)
      <i>Study design</i>: Crossover double blind, randomized placebo-controlled trial.<p> <p><i>Objectives</i>: Circadian oscillators are located both in the brain and in peripheral organs. Melatonin, the main brain-derived hormone governing circadian variations, is highly associated with daylight patterns. However, in subjects with tetraplegia the melatonin levels are blunted. Here we studied peripheral ...

    • Norwegian General Practitioners’ Perspectives on Implementation of a Guided Web-Based Cognitive Behavioral Therapy for Depression: A Qualitative Study 

      Wilhelmsen, Maja; Høifødt, Ragnhild Sørensen; Kolstrup, nils; Waterloo, Knut; Eisemann, Martin; Chenhall, Richard; Risør, Mette Bech (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Novel chemical-physical autopsy investigation in sudden infant death and sudden intrauterine unexplained death syndromes 

      Gatti, Antonietta M; Ristic, Marko; Stanzani, Stefano; Lavezzi, Anna M (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-08)
      Aim: Verify the presence of inorganic nanoparticle entities in brain tissue samples from sudden infant death syndrome (SIDS)/sudden intrauterine unexplained death syndrome (SIUDS) cases. The presence of inorganic debris could be a cofactor that compromises proper brain tissue functionality. Materials & methods: A novel autopsy approach that consists of neuropathological analysis procedures ...

    • Novel genomic islands and a new vanDsubtype in the first sporadic VanD-type vancomycin resistant enterococci in Norway 

      AL-Rubaye, Mushtaq Talib Shawi; Janice, Jessin; Bjørnholt, Jørgen Vildershøj; Jakovljev, Aleksandra; Hultström, Maria Elisabeth; Sundsfjord, Arnfinn; Hegstad, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-23)
      Background - Vancomycin-resistant enterococci (VRE) represent several types of transferable vancomycin resistance gene clusters. The vanD type, associated with moderate to high level vancomycin resistance, has only sporadically been described in clinical isolates. The aim of this study was to perform a genetic characterization of the first VanD-type VRE strains detected in Norway.<p> <p>Methods ...

    • Novel human melanoma brain metastasis models in athymic nude fox1nu mice: Site-specific metastasis patterns reflecting their clinical origin 

      Svendsen, Henrik Aasrum; Meling, Torstein Ragnar; Nygaard, Vigdis; Waagene, Stein; Russnes, Hege Elisabeth Giercksky; Juell, Siri; Rogne, Siril Gudmundson; Pahnke, Jens; Helseth, Eirik; Fodstad, Øystein; Mælandsmo, Gunhild Mari (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-06)
      Background: Malignant melanomas frequently metastasize to the brain, but metastases in the cerebellum are underrepresented compared with metastases in the cerebrum.<p> <p>Methods: We established animal models by injecting intracardially in athymic nude fox1<sup>nu</sup> mice two human melanoma cell lines, originating from a cerebral metastasis (HM19) and a cerebellar metastasis (HM86).<p> <p>Results: ...

    • A novel lncRNA derived from an ultraconserved region: lnc- uc.147, a potential biomarker in luminal A breast cancer 

      Zambalde, Erika Pereira; Bayraktar, Recep; Jucoski, Tayana Schultz; Ivan, Cristina; Rodrigues, Ana Carolina de Mello Alves; Mathias, Carolina; Knutsen, Erik; Silveira de Lima, Rubens; Gradia, Daniela Fiori; Fonseca, Enilze Maria de Souza; Hannash, Samir; Calin, George A.; Oliveira, Jaqueline Carvalhode (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-13)
      The human genome contains 481 ultraconserved regions (UCRs), which are genomic stretches of over 200 base pairs conserved among human, rat, and mouse. The majority of these regions are transcriptionally active (T-UCRs), and several have been found to be differentially expressed in tumours. Some T-UCRs have been functionally characterized, but of those few have been associated to breast cancer (BC). ...

    • A novel non-canonical Wnt signature for prostate cancer aggressiveness 

      Sandsmark, Elise; Hansen, Ailin Falkmo; Selnæs, Kirsten Margrete; Bertilsson, Helena; Bofin, Anna M.; Wright, Alan J.; Viset, Trond; Richardsen, Elin; Drabløs, Finn Sverre; Bathen, Tone Frost; Tessem, May-Britt; Rye, Morten Beck (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-24)
      Activation of the Canonical Wnt pathway (CWP) has been linked to advanced and metastatic prostate cancer, whereas the Wnt5a-induced non-canonical Wnt pathway (NCWP) has been associated with both good and poor prognosis. A newly discovered NCWP, Wnt5/Fzd2, has been shown to induce epithelial-to-mesenchymal transition (EMT) in cancers, but has not been investigated in prostate cancer. The aim of this ...

    • The Novel Oncolytic Compound LTX-401 Induces Antitumor Immune Responses in Experimental Hepatocellular Carcinoma 

      Mauseth, Brynjar; Camilio, Ketil Andre; Shi, Jihua; Hammarström, Clara Louise; Rekdal, Øystein; Sveinbjørnsson, Baldur; Line, Pål Dag (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-21)
      LTX-401 is a novel oncolytic compound designed for the local treatment of solid tumors. In the present study, we have examined the applicability and efficacy of LTX-401 in a rat model JM1 hepatocellular carcinoma, with particular interest in its ability to induce antitumor immunity. LTX-401 induces necrotic cell death followed by the release of immunogenic cell death mediators such as high-mobility ...

    • Novel targets for delaying aging: The importance of the liver and advances in drug delivery 

      Hunt, Nicholas J; McCourt, Peter Anthony; Le Couteur, David George; Cogger, Victoria C (Journal article; Tidsskriftartikkel, 2018-09-21)
      Age-related changes in liver function have a significant impact on systemic aging and susceptibility to age-related diseases. Nutrient sensing pathways have emerged as important targets for the development of drugs that delay aging and the onset age-related diseases. This supports a central role for the hepatic regulation of metabolism in the association between nutrition and aging. Recently, a role ...

    • A Novel Truncated Form of Nephronectin Is Present in Small Extracellular Vesicles Isolated from 66cl4 Cells 

      Toraskar, Jimita Prashant; Norvoll Magnussen, Synnøve; Hagen, Lars; Sharma, Animesh; Hoang, Linh; Bjørkøy, Geir; Svineng, Gunbjørg; Steigedal, Tonje S. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-01)
      Extracellular vesicles are emerging as biomarkers in breast cancer. Our recent report suggested that an intracellular granular staining pattern of the extracellular matrix protein nephronectin (NPNT) in breast tumor sections correlated with a poor prognosis. Furthermore, the results showed that NPNT is localized in extracellular vesicles derived from mouse breast cancer cells. In this study, we ...

    • Nox4 regulates InsP3 receptor‐dependent Ca2+ release into mitochondria to promote cell survival 

      Beretta, Matteo; Santos, Celio X.C.; Molenaar, Chris; Hafstad, Anne Dragøy; Miller, Chris CJ; Revazian, Aram; Betteridge, Kai; Schröder, Katrin; Streckfuß-Bömeke, Katrin; Doroshow, James H; Fleck, Roland A; Su, Tsung-Ping; Belousov, Vsevelod; Parsons, Maddy; Shah, Ajay M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-10)
      Cells subjected to environmental stresses undergo regulated cell death (RCD) when homeostatic programs fail to maintain viability. A major mechanism of RCD is the excessive calcium loading of mitochondria and consequent triggering of the mitochondrial permeability transition (mPT), which is especially important in post‐mitotic cells such as cardiomyocytes and neurons. Here, we show that stress‐induced ...

    • Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma 

      Pölonen, Petri; Jawahar Deen, Ashik; Leinonen, Hanna M.; Jyrkkänen, Henna-Kaisa; Kuosmanen, Suvi; Mononen, Mimmi; Jain, Ashish; Tuomainen, Tomi; Pasonen-Seppänen, Sanna; Hartikainen, Jaana M.; Mannermaa, Arto; Nykter, Matti; Tavi, Pasi; Johansen, Terje; Heinäniemi, Merja; Levonen, Anna-Liisa (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-23)
      Accumulating evidence suggests that constitutively active Nrf2 has a pivotal role in cancer as it induces pro-survival genes that promote cancer cell proliferation and chemoresistance. The mechanisms of Nrf2 dysregulation and functions in cancer have not been fully characterized. Here, we jointly analyzed the Broad-Novartis Cancer Cell Line Encyclopedia (CCLE) and the Cancer Genome Atlas (TCGA) ...

    • Nuclear group I introns in self-splicing and beyond 

      Hedberg, Annica; Johansen, Steinar (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Group I introns are a distinct class of RNA self-splicing introns with an ancient origin. All known group I introns present in eukaryote nuclei interrupt functional ribosomal RNA genes located in ribosomal DNA loci. The discovery of the Tetrahymena intron more than 30 years ago has been essential to our understanding of group I intron catalysis, higher-order RNA structure, and RNA folding, but ...

    • Nutrient patterns and their food sources in an international study setting: Report from the EPIC study 

      Moskal, Aurelie; Pisa, Pedro T; Ferrari, Pietro; Byrnes, Graham; Freisling, Heinz; Boutron-Ruault, Marie-Christine; Cadeau, Claire; Nailler, Laura; Wendt, Andrea; Kühn, Tilman; Boeing, Heiner; Buijsse, Brian; Tjønneland, Anne; Halkjær, Jytte; Dahm, Christina C; Chiuve, Stephanie E; Quirós, Jose R; Buckland, Genevieve; Molina-Montes, Esther; Amiano, Pilar; Huerta Castaño, José M; Gurrea, Aurelio Barricarte; Khaw, Kay-Tee; Lentjes, Marleen A; Key, Timothy J; Romaguera, Dora; Vergnaud, Anne-Claire; Trichopoulou, Antonia; Bamia, Christina; Orfanos, Philippos; Palli, Domenico; Pala, Valeria; Tumino, Rosario; Sacerdote, Carlotta; De Magistris, Maria Santucci; Bueno-de-Mesquita, H Bas; Ocké, Marga C; Beulens, Joline W J; Ericson, Ulrika; Drake, Isabel; Nilsson, Lena M; Winkvist, Anna; Weiderpass, Elisabete; Hjartåker, Anette; Riboli, Elio; Slimani, Nadia (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Ny generasjon HPV-tester på vent 

      Sørbye, Sveinung Wergeland; Gutteberg, Tore Jarl; Vintermyr, Olav Karsten (Chronicle; Kronikk, 2010-09-18)
      Ny forskning viser at gentester for humant papillomvirus (HPV) siler ut de behandlingstrengende i langt større grad enn celleprøver. Samtidig er det grunn til å tro at mRNA-tester bør velges fremfor DNA-tester.

    • Nytt håp for voksne leukemipasienter 

      Arranz, Lorena; Juul, Kjersti (Chronicle; Kronikk, 2023-04-11)
      Norske forskere er i ferd med å utvikle en behandling som øker overlevelsen for voksne leukemipasienter.