Institutt for klinisk medisin: Nye registreringer

Viser treff 601-620 av 1974

    • Five years of exercise intervention at different intensities and development of white matter hyperintensities in community dwelling older adults, a Generation 100 sub-study 

      Arild, Anette; Vangberg, Torgil Riise; Nikkels, Hanne; Lydersen, Stian; Wisløff, Ulrik; Stensvold, Dorthe; Håberg, Asta (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-18)
      We investigated if a five-year supervised exercise intervention with moderate-intensity continuous training (MICT) or high-intensity interval training (HIIT) versus control; physical activity according to national guidelines, attenuated the growth of white matter hyperintensities (WMH). We hypothesized that supervised exercise, in particular HIIT, reduced WMH growth. Older adults from the general ...

    • Small- and large-fiber neuropathy after 40 years of type 1 diabetes associations with glycemic control and advanced protein glycation: the Oslo Study 

      Sveen, Kari Anne; Karimé, Bassam; Jørum, Ellen; Mellgren, Svein Ivar; Fagerland, Morten; Monnier, Vincent; Dahl-Jørgensen, Knut; Hanssen, Kristian Folkvord (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-10-15)
      OBJECTIVE To study large- and small-nerve fiber function in type 1 diabetes of long duration and associations with HbA<sub>1c</sub> and the advanced glycation end products (AGEs) N-&#949-(carboxymethyl)lysine (CML) and methylglyoxal-derived hydroimidazolone.<p> <p>RESEARCH DESIGN AND METHODS In a long-term follow-up study, 27 persons with type 1 diabetes of 40 &#177 3 years duration underwent ...

    • Tumour-suppressor microRNAs let-7 and mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastoma 

      Buechner, Jochen; Tømte, Ellen; Haug, Bjørn Helge; Henriksen, Jørn Remi; Løkke, Cecilie; Flægstad, Trond; Einvik, Christer (Journal article; Tidsskriftartikkel; Peer reviewed, 2011-06-07)
      BACKGROUND: MicroRNAs (miRNAs) regulate expression of many cancer-related genes through posttranscriptional repression of their mRNAs. In this study we investigate the proto-oncogene MYCN as a target for miRNA regulation.<p> <p>METHODS: A luciferase reporter assay was used to investigate software-predicted miRNA target sites in the 30 -untranslated region (30 UTR) of MYCN. The miRNAs were ...

    • Implementation of international society guidelines on chorionicity determination in twins: A multi-Center cohort study in mainland China 

      Wu, Su-Wen; Zhou, Qiongjie; Xiao, Xirong; Xiong, Yu; Liang, Huan; Shen, Jie; Barrett, Jon; Wang, Hong; Li, Xiao-Tian (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-02)
      Objective: Ultrasound determination of chorionicity is poor in early pregnancy in China. In an effort to increase the accuracy rate of prompt chorionicity determination, clinical training was provided to primary care physicians. This study assesses the effects of implementing clinical guidelines on chorionicity determination.<p> <p>Methods: A multi‑centered cohort study was conducted between ...

    • Plasma Lipopolysaccharide Is Closely Associated With Glycemic Control and Abdominal Obesity: Evidence from bariatric surgery 

      Trøseid, Marius; Nestvold, Torunn Kristin; Rudi, Knut; Thoresen, Hanna; Nielsen, Erik Waage; Lappegård, Knut Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-10-15)
      OBJECTIVE It is of vital importance to elucidate the triggering factors of obesity and type 2 diabetes to improve patient care. Bariatric surgery has been shown to prevent and even cure diabetes, but the mechanism is unknown. Elevated levels of lipopolysaccharide (LPS) predict incident diabetes, but the sources of LPS are not clarified. The objective of the current study was to evaluate the ...

    • Liver Regeneration in Surgical Animal Models - A Historical Perspective and Clinical Implications 

      Mortensen, Kim Erlend; Revhaug, Arthur (Journal article; Tidsskriftartikkel; Peer reviewed, 2010-12-07)
      Methods/Aims: Despite improved preoperative evaluation, surgical techniques and perioperative intensive care, some patients still experience postoperative liver failure in part due to insufficient regeneration. The aim of this review is to give the reader a historical synopsis of the major trends in animal research on liver regeneration from the early experiments in 1877 up to modern investigation. ...

    • Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia 

      Nordlund, Jessica; Bäcklin, Christopher L.; Wahlberg, Per; Busche, Stephan; Berglund, Eva C.; Eloranta, Maija-Leena; Flægstad, Trond; Forestier, Erik; Frost, Britt-Marie; Harila-Saari, Arja; Heyman, Mats; Jonsson, Olafur G.; Larsson, Rolf; Palle, Josefine; Rönnblom, Lars; Schmiegelow, Kjeld; Sinnett, Daniel; Söderhäll, Stefan; Pastinen, Tomi; Gustafsson, Mats G.; Lönnerholm, Gudmar; Syvänen, Ann-Christine (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-09-24)
      Background: Although aberrant DNA methylation has been observed previously in acute lymphoblastic leukemia (ALL), the patterns of differential methylation have not been comprehensively determined in all subtypes of ALL on a genome-wide scale. The relationship between DNA methylation, cytogenetic background, drug resistance and relapse in ALL is poorly understood.<p> <p>Results: We surveyed the ...

    • Do pre-hospital anaesthesiologists reliably predict mortality using the NACA severity score? A retrospective cohort study 

      Raatiniemi, Lasse; Mikkelsen, Kim; Fredriksen, Knut; Wisborg, Torben (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-10-17)
      Introduction: The National Advisory Committee on Aeronautics’ (NACA) severity score is widely used in pre-hospital emergency medicine to grade the severity of illness or trauma in patient groups but is scarcely validated. The aim of this study was to assess the score’s ability to predict mortality and need for advanced in-hospital interventions in a cohort from one anaesthesiologistmanned helicopter ...

    • Serglycin Is a Major Proteoglycan in Polarized Human Endothelial Cells and Is Implicated in the Secretion of the Chemokine GRO alpha/CXCL1 

      Meen, Astri Jeanette; Øynebråten, Inger; Reine, Trine M.; Duelli, Annette; Svennevig, Katja Christiane; Pejler, Gunnar; Jenssen, Trond Geir; Kolset, Svein Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2011-01-28)
      Proteoglycan (PG) expression was studied in primary human umbilical vein endothelial cells (HUVEC). RT-PCR analyses showed that the expression of the PG serglycin core protein was much higher than that of the extracellular matrix PG decorin and the cell surface PG syndecan-1. PG biosynthesis was further studied by biosynthetic [<sup>35</sup>S]sulfate labeling of polarized HUVEC. Interestingly, ...

    • Dødsfall og personskader ved bruk av ATV og snøscooter i Nord-Norge i 2013–14 

      Rønning, Tone; Grov, Ellen Karine; Wisborg, Torben (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-08)
      BAKGRUNN Det er tidligere vist høy forekomst av skader og dødsfall i forbindelse med bruk av snøscooter og andre terrengkjøretøy i Nord-Norge. Det finnes ikke tilgjengelig offentlig statistikk der disse funnene kan følges over tid. Målet med studien var å fremskaffe nye prevalenstall for skader og dødsfall etter bruk av snøscooter og andre terrengkjøretøy og å bedømme samsvar mellom ulike datakilder.<p> ...

    • Levels of Peripheral Circulating IL-6 and IL-10 Decrease Over Time Despite High Depression Burden in PTSD Patients 

      Bramness, Jørgen Gustav; Lien, Lars; Toft, Helge (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-05)
      Background: Patients with combined depression symptoms and post-traumatic stress disorder (PTSD) often exhibit high levels of circulating inflammatory biomarkers as either a cause or consequence of their disease. We aimed to investigate how cytokines and depression symptoms develop with one-year follow-up and compare them with non-PTSD patients.<p> <p>Methods: The study had a longitudinal design ...

    • Retinal vascular calibre and response to light exposure and serial imaging 

      Hanno, Therese von; Sjølie, Anne Katrin; Mathiesen, Ellisiv B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-07-04)
      Purpose: To investigate whether retinal vessel calibre measurements on optical retinal photography are affected by light and dark exposure prior to photography and whether the vessel calibre changes during an imaging sequence of several images. <p>Methods: Digital optical retinal photographs were obtained from 32 healthy adults in two separate image sequences of six images during 1 min; one ...

    • Changes in the secretory profile of NSCLC-associated fibroblasts after ablative radiotherapy: Potential impact on angiogenesis and tumor growth 

      Hellevik, Turid; Pettersen, Ingvild; Berg, Vivian; Bruun, Jack-Ansgar; Bartnes, Kristian; Busund, Lill-Tove; Chalmers, Anthony; Bremnes, Roy M.; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-03-05)
      In the context of radiotherapy, collateral effects of ablative ionizing radiation (AIR) on stromal components of tumors remains understudied. In this work, cancer-associated fibroblasts (CAFs) isolated from freshly resected human lung tumors were exposed to AIR (1x18Gy) and analyzed for their release of paracrine factors. Inflammatory mediators and regulators of angiogenesis and tumor growth were ...

    • Palliative non-small cell lung cancer treatment and end-of-life care stratified by sex and childlessness: an important interplay in unmarried patients? 

      Nieder, Carsten; Aanes, Siv Gyda; Haukland, Ellinor Christin (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-22)
      Purpose To analyze the interplay of sex and presence of children in unmarried patients with non-small cell lung cancer, because previous studies suggested sex-related disparities. Adult children may participate in treatment decisions and provision of social support or home care.<p> <p>Methods Retrospective single-institution analysis of 186 unmarried deceased patients, managed according to ...

    • Risk of venous thromboembolism from use of oral contraceptives containing different progestogens and oestrogen doses: Danish cohort study, 2001-9 

      Lidegaard, O; Nielsen, L.; Skovlund, CW; Skjeldestad, Finn Egil; Løkkegaard, Ellen (Journal article; Tidsskriftartikkel; Peer reviewed, 2011-10-25)
      Objective To assess the risk of venous thromboembolism from use of combined oral contraceptives according to progestogen type and oestrogen dose.<p> <p>Design National historical registry based cohort study. <p>Setting Four registries in Denmark. <p>Participants Non-pregnant Danish women aged 15-49 with no history of thrombotic disease and followed from January 2001 to December 2009. <p>Main ...

    • Impact of hidradenitis suppurativa on work loss, indirect costs and income 

      Tzellos, Thrasyvoulos; Yang, H; Mu, F; Calimlim, B; Signorovitch, J (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-18)
      Background Hidradenitis suppurativa (HS), a chronic cutaneous disease, can negatively affect work life. Objectives This retrospective cohort study evaluates the indirect burden among employed patients with HS in the U.S.A.<p> <p>Methods Newly diagnosed and general patients with HS, who were employees (age 18–64 years) from a large claims database (Q1 1999 to Q1 2015), were matched 1 : 5 to ...

    • Association of vitamin D status with arterial blood pressure and hypertension risk: A mendelian randomisation study 

      Vimaleswaran, Kerani S.; Cavadino, Alana; Berry, Diane J.; Jorde, Rolf; Grimnes, Guri; Dieffenbach, Aida Karina; Lu, Chen; Alves, Alexessander Couto; Heerspink, Hiddo J. Lambers; Tikkanen, Emmi; Eriksson, Joel; Wong, Andrew; Mangino, Massimo; Jablonski, Kathleen A.; Nolte, Ilja M.; Houston, Denise K.; Ahluwalia, Tarunveer Singh; van der Most, Peter J.; Pasko, Dorota; Zgaga, Lina; Thiering, Elisabeth; Schöttker, B; Saum, KU; Brenner, H; Järvelin, MR; Tzoulaki, I; Snieder, H; Stolk, RP; Hartman, CA; de Boer, RA; van der Harst, P; Navis, G; de Borst, MH; Lorentzon, M; Mellström, D; Ohlsson, C; Hardy, R; Kuh, D; Cooper, JA; Acharya, J; Humphries, SE; Hingorani, AD; Kumari, M; Kivimaki, M; Spector, TD; Kritchevsky, SB; Lohman, KK; Sørensen, TIA; Frayling, TM; Campbell, H; Theodoratou, E; Fraser, RM; Wilson, JF; Rudan, I; Price, JF; McLachlan, S; Vitart, V; Navarro, P; Huffman, JE; Hayward, C; Wright, AF; Tiesler, CMT; Heinrich, J; McCarthy, MI; Ingelsson, E; Arden, N; Cooper, C; Dupuis, J; Herzig, KH; Sebert, S; Pouta, A; Laitinen, J; Kleber, ME; März, W; Jameson, K; Osmond, C; Raitakari, O; Ripatti, S; Lahti, J; Eriksson, JG; Penninx, BW; Billings, LK; Florez, JC; Rejnmark, L; Langdahl, BL; Paternoster, L; Hernandez, DG; Byberg, L; Michaelsson, K; Hagström, E; Melhus, H; Ljunggren, O; Lind, L; Jula, A; Polasek, O; Salomaa, V; Karlsson, M; Bandinelli, S; Lehtimäki, T; Wang, TJ; Pilz, S; Whittaker, JC (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-06-25)
      Background Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with high arterial blood pressure and hypertension risk, but whether this association is causal is unknown. We used a mendelian randomisation approach to test whether 25(OH)D concentration is causally associated with blood pressure and hypertension risk.<p> <p>Methods In this mendelian randomisation study, we generated ...

    • Socioeconomic and geographic differences in ablation of atrial fibrillation in Norway - a national cohort study 

      Olsen, Frank; Uleberg, Bård Erling; Jacobsen, Bjarne K.; Tande, Pål Morten; Bugge, Einar; Balteskard, Lise (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-14)
      <p><i>Background -</i> The aim of this study was to analyse whether there are patient related or geographic differences in the use of catheter ablation among atrial fibrillation patients in Norway. <p><i>Methods -</i> National population-based data on individual level of all Norwegians aged 25 to 75 diagnosed with atrial fibrillation from 2008 to 2017 were used to study the proportion treated with ...

    • Cellular and molecular mediators of intestinal fibrosis 

      Lawrance, Ian; Rogler, Gerhard; Bamias, Giorgos; Breynaert, Chrstine; Florholmen, Jon; Pellino, Gianluca; Reif, Shimon; Speca, Silvia; Latella, Giovanni (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11-02)
      Intestinal fibrosis is a major complication of the inflammatory bowel diseases (IBD) and although inflammation is necessary for its development, it would appear that it plays a minor role in its progression as anti-inflammatory treatments in IBD do not prevent fibrosis once it has started. The processes that regulate fibrosis would thus appear to be distinct from those regulating inflammation and, ...

    • Poor prognosis patients with inoperable locally advanced NSCLC and large tumors benefit from palliative chemoradiotherapy: A subset analysis from a randomized clinical phase III trial 

      Strøm, Hans Henrik; Bremnes, Roy M.; Sundstrøm, Stein Harald; Helbekkmo, Nina; Aasebø, Ulf (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11-20)
      Introduction: Poor prognosis patients with bulky stage III locally advanced non–small-cell lung cancer may not be offered concurrent chemoradiotherapy (CRT). Following a phase III trial concerning the effect of palliative CRT in inoperable poor prognosis patients, this analysis was performed to explore how tumor size influenced survival and health-related quality of life (HRQOL).<p> <p>Methods: ...