Doktorgradsavhandlinger (Helsefak): Nye registreringer
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“Light my fire” - Perspectives on Motivation, Helpfulness and Implementation of Guided Internet-based Cognitive Behavioral therapy.
(Doctoral thesis; Doktorgradsavhandling, 2015-03-13)Depression is common and imposes tremendous burdens for patients, their family and society. Implementation of internet-based cognitive behavioural therapy (ICBT) within general practice is recommended. Better results have been shown for treatment with ICBT when support is given, and therefore there is interest in exploring guided ICBT as an affordable alternative for treatment in the early stage ... -
A study of changes in glucose metabolism and inflammatory markers in morbidly obese patients undergoing bariatric surgery
(Doctoral thesis; Doktorgradsavhandling, 2015-06-08)Summary Obesity is considered a worldwide pandemic. Morbidly obese patients are at risk of developing comorbidity such as diabetes mellitus type 2, hypertension and cardiovascular disease. The mechanisms behind the development of such complications in morbidly obese patients are still not fully understood, but low-grade inflammation and visceral adiposity are both involved. Effective treatment that ... -
Ecotoxicological assessment of Roundup-ready soybean agriculture investigated in a D. magna model
(Doctoral thesis; Doktorgradsavhandling, 2015-06-09)Transgenic glyphosate tolerant soybeans are constituents of an industrial production system with specific agricultural practices and supplementary agrochemicals as interwoven additional elements. Thus the material produced should not be seen as an isolated product of a specific modified genotype but rather as a product of a tailored agriculture system. This globally dominant crop has been in open ... -
Clonal Diversity and multiresistance in Quinolone Resistant Escherichia coli.
(Doctoral thesis; Doktorgradsavhandling, 2015-03-26)Denne studien har undersøkt Escherichia coli resistente for kinoloner, en bredpektret gruppe antibiotika. Målet har vært å finne ut hvorfor disse bakteriene oftere er resistente mot andre antoibiotikagrupper. Studiet er basert på molekylærgenetisk analyser - herunder klonal analyse, plasmidanalyser og undersøkelse av resistensgener. Resultatene viser at kinolonresistente Escherichia coli er ofte ... -
Advanced flow cytometry to study signaling pathways and predict outcome in B cell malignancies
(Doctoral thesis; Doktorgradsavhandling, 2015-01-16) -
Development of biomimetic phospholipid vesicle-based permeation assays (PVPA) as screening tool in drug development
(Doctoral thesis; Doktorgradsavhandling, 2015-04-17)Although several routes of administration can be utilized to bring a drug to the desired site of action, oral administration is still the most important and prevalent route of administration, due to its cost efficiency, convenience and patient compliance. A prerequisite for successful oral therapy is the ability of a drug to cross the gastrointestinal barrier. Over the past two decades, the ... -
General Practitioners’ Decisions to Refer Patients to Secondary Care – Referral Rates, Reasons for Referral and Expected Medical Benefit of the Referrals
(Doctoral thesis; Doktorgradsavhandling, 2015-04-09)Summary Background The referral rates of general practitioners (GPs) are an important determinant of secondary care utilisation. The considerable variation in these rates between GPs cannot be explained by patient morbidity alone. Other factors, like health care organisation, GP characteristics and patient preference play an important role, but the extent of their mutual contributions is not ... -
Extended-spectrum β-lactamases and carbapenemases in clinical isolates of Enterobacteriaceae in Norway. Aspects of detection and epidemiology.
(Doctoral thesis; Doktorgradsavhandling, 2015-04-16) -
Pulse oximetry in an adult population: Predictors of low oxygen saturation and associations with mortality; The Tromsø Study
(Doctoral thesis; Doktorgradsavhandling, 2015-03-19)Pulsoksymetri er en enkel undersøkelsesmetode for å beregne metningen av oksygen (O2) i arterielt blod (SpO2). Lave verdier kan være indikasjon på hjerte- og/eller lungesykdom. Ingen befolkningsundersøkelser har tidligere sett på oksygenmetning i en voksen befolkning. Avhandlingen er basert på de to befolkningsundersøkelsene, Tromsø 5 (2001/2002) og Tromsø 6 (2007/2008). I disse ble det gjort ... -
Antibiotic use Human consumption patterns and effect on bacteria
(Doctoral thesis; Doktorgradsavhandling, 2015-03-17)Prescriptions of antibiotics in Norway, and the effect of antibiotics on bacteria were investigated. The aim was to describe the consumption of antibiotics through prescriptions to patients and address how antibiotics can favour bacterial resistance. Several methods were applied, multivariate statistics, quantile regression and mathematical modelling of experimental conditions aided in the investigations. ... -
IQ as a Predictor and Moderator of Children’s Mental Health Status
(Doctoral thesis; Doktorgradsavhandling, 2015-01-27) -
“Å sette staven igjen” – tilhørighet til familie, sted, personer og natur. Å fremme et meningsfylt liv for personer med demenssykdom i sykehjem i Nord-Norge.
(Doctoral thesis; Doktorgradsavhandling, 2015-01-23)Spørsmålet ”Eldre mennesker med demenssykdom: Hva betyr tilhørighet i eget liv for en meningsfylt tilværelse i sykehjemmet?” ble undersøkt ved intervju og feltarbeid med personer med demenssykdom, pårørende, pleiere og sykepleieledere i sykehjem i Nord-Norge. Et livsløpsperspektiv ble lagt til grunn. Dataene fra intervjuene ble analysert ved narrativ- og innholdsanalyse. Å få demenssykdom, og ... -
Factors that determine children’s participation in child welfare decision making.
(Doctoral thesis; Doktorgradsavhandling, 2015-03-05) -
Anti-Obesity and Anti-Hypertensive Action of Calanus Oil
(Doctoral thesis; Doktorgradsavhandling, 2015-03-04)In this doctoral project we have examined the biological effects of Calanus oil in a mouse model of obesity. Calanus oil is extracted from the marine copepod Calanus finmarchicus and is one of the richest sources of poly-unsaturated fatty acids in nature. C57BL/6J mice were given a high-fat diet (HFD) over a 27 wk period in order to induce obesity, which was reflected in deposition of considerable ... -
The use of self-administered questionaires about food habits.
(Doctoral thesis; Doktorgradsavhandling, 1988) -
Oral Squamous Cell Carcinoma - Role of the Plasminogen Activation System in Tumour Progression.
(Doctoral thesis; Doktorgradsavhandling, 2015-01-30)Oral squamous cell carcinoma (OSCC) is an aggressive and unpredictable cancer with a high tendency to recur and metastasise. Despite increasing efforts to improved treatment, the 5-year survival rate is still low. We discovered that low expression levels of the urokinase plasminogen activator receptor (uPAR) and the plasminogen activator inhibitor-1 (PAI-1) two proteins normally involved in the ... -
The Conrad Study - A randomised, multicenter phase III trial of combination chemotherapy ± thoracic radiotherapy in the treatment of patients in poor condition with stage III non-small cell lung cancer not eligible for radical therapy
(Doctoral thesis; Doktorgradsavhandling, 2014-12-10)The thesis constitutes the collected report on an RCT the candidate has conducted on behalf of the Norwegian Lung Cancer Study Group. In addition to three scientific articles published in international peer-reviewed journal, it consists of texts on the background, the choice of methods and material, as well as results and discussion of the treatment regimens that have been studied in the trial. ... -
Diagnosis of pneumonia in adults in general practice.
(Doctoral thesis; Doktorgradsavhandling, 1992) -
Aspects of breast cervical cancer screening
(Doctoral thesis; Doktorgradsavhandling, 1992)The purpose of the thesis was to investigate aspects of breast cancer screening such as the feasibility, non-attendance and adverse effects of a general mammography screening program. A second objective was to examine whether risk factors for cervical neoplasia could be identified for potential utilization in a selective screening program for cervical cancer. -
Headache and neck or shoulderpain. An analysis of musculoskeletal problems in three comprehensive population studies in Northern Norway.
(Doctoral thesis; Doktorgradsavhandling, 1992)