• Body weight and composition endpoints in cancer cachexia clinical trials: Systematic Review 4 of the cachexia endpoints series 

  Brown, Leo R.; Sousa, Mariana S.; Yule, Michael S.; Baracos, Vickie E.; McMillan, Donald C.; Arends, Jann; Balstad, Trude Rakel; Bye, Asta; Dajani, Olav; Dolan, Ross D.; Fallon, Marie T.; Greil, Christine; Hjermstad, Marianne Jensen; Jakobsen, Gunnhild; Maddocks, Matthew; McDonald, James; Ottestad, Inger; Phillips, Iain; Sayers, Judith; Simpson, Melanie Rae; Vagnildhaug, Ola Magne; Solheim, Tora S; Laird, Barry J; Skipworth, Richard J.E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-13)

  Significant variation exists in the outcomes used in cancer cachexia trials, including measures of body composition, which are often selected as primary or secondary endpoints. To date, there has been no review of the most commonly selected measures or their potential sensitivity to detect changes resulting from the interventions being examined. The aim of this systematic review is to assess the ...
• Hagfish genome elucidates vertebrate whole-genome duplication events and their evolutionary consequences 

  Yu, Daqi; Ren, Yandong; Uesaka, Masahiro; Beavan, Alan; Muffato, Matthieu; Shen, Jieyu; Li, Yongxin; Sato, Iori; Wan, Wenting; Clark, James; Keating, Joseph; Carlisle, Emily; Dearden, Richard; Giles, Sam; Randle, Emma; Sansom, Robert; Feuda, Roberto; Fleming, James Frederick; Sugahara, Fumiaki; Cummins, Carla; Patricio, Mateus; Akanni, Wasiu; D'Aniello, Salvatore; Bertolucci, Christiano; Irie, Naoki; Alev, Cantas; Sheng, Guojun; de Mendoza, Alex; Maeso, Ignacio; Irimia, Manuel; Fromm, Bastian; Peterson, Kevin J; Das, Sabyasachi; Hirano, Masayuki; Rast, Jonathan P; Cooper, Max; Paps, Jordi; Pisani, Davide; Kuratani, Shigeru; Martin, Fergal J.; Wang, Wen; Donoghue, Philip C J; Zhang, Yong E.; Pascual-Anaya, Juan (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-12)

  Polyploidy or whole-genome duplication (WGD) is a major event that drastically reshapes genome architecture and is often assumed to be causally associated with organismal innovations and radiations. The 2R hypothesis suggests that two WGD events (1R and 2R) occurred during early vertebrate evolution. However, the timing of the 2R event relative to the divergence of gnathostomes ( jawed vertebrates) ...
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  Targeted temperature control following traumatic brain injury: ESICM/NACCS best practice consensus recommendations 

  Lavinio, Andrea; Coles, Jonathan P.; Robba, Chiara; Aries, Marcel; Bouzat, Pierre; Chean, Dara; K Frisvold, Shirin; Galarza, Laura; Helbok, Raimund; Hermanides, Jeroen; van der Jagt, Mathieu; Menon, David K.; Meyfroidt, Geert; Payen, Jean-Francois; Poole, Daniele; Rasulo, Frank; Rhodes, Jonathan; Sidlow, Emily; Steiner, Luzius A.; Taccone, Fabio Silvio; Takala, Riikka (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-20)

  Aims and scope The aim of this panel was to develop consensus recommendations on targeted temperature control (TTC) in patients with severe traumatic brain injury (TBI) and in patients with moderate TBI who deteriorate and require admission to the intensive care unit for intracranial pressure (ICP) management.<p> <p>Methods A group of 18 international neuro-intensive care experts in the acute ...
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  Overview of the MOSAiC expedition: Ecosystem 

  Fong, Allison A.; Hoppe, Clara J. M.; Aberle, Nicole; Ashjian, Carin; Assmy, Philipp Kurt Wolf; Bai, Youcheng; Bakker, Dorothee C. E.; Balmonte, John Paul; Barry, Kevin; Bertilsson, Stefan; Boulton, William; Bowman, Jeff; Bozzato, Deborah; Bratbak, Gunnar; Buck, Moritz; Campbell, Robert G.; Castellani, Giulia; Chamberlain, Emelia J.; Chen, Jianfang; Chierici, Melissa; Cornils, Astrid; Creamean, Jessie; Damm, Ellen; Dethloff, Klaus; Droste, Elise S.; Ebenhöh, Oliver; Eggers, Sarah Lena; Engel, Anja; Flores, Hauke; Fransson, Agneta; Frickenhaus, Stephan; Gardner, Jessie; Gelfman, Cecilia E.; Granskog, Mats; Graeve, Martin; Havermans, Charlotte; Heuzé, Céline; Hildebrandt, Nicole; Hill, Thomas C. J.; Hoppema, Mario; Immerz, Antonia; Jin, Haiyan; Koch, Boris P.; Kong, Xianyu; Kraberg, Alexandra C.; Lan, Musheng; Lange, Benjamin Allen; Larsen, Aud; Lebreton, Benoit; Leu, Eva Susanne; Loose, Brice; Maslowski, Wieslaw; Mavis, Camille; Metfies, Katja; Mock, Thomas; Müller, Oliver; Marcel, Nicolaus; Niehoff, Barbara; Nomura, Daiki; Nöthig, Eva-Maria; Oggier, Marc; Oldenburg, Ellen; Olsen, Lasse Mork; Peeken, Ilka; Perovich, Donald K.; Popa, Ovidiu; Rabe, Benjamin; Ren, Jian; Rex, Markus; Rinke, Annette; Rokitta, Sebastian; Rost, Björn; Sakinan, Serdar S.; Salganik, Evgenii; Schaafsma, Fokje L.; Schäfer, Hendrik; Schmidt, Katrin; Shoemaker, Katyanne; Shupe, Matthew D.; Snoeijs-Leijonmalm, Pauline; Stefels, Jacqueline; Svenson, Anders; Tao, Ran; Sinhué, Torres-Valdés; Torstensson, Anders; Toseland, Andrew; Ulfsbo, Adam; Leeuwe, Maria A. van; Vortkamp, Martina; Webb, Alison L.; Zhuang, Yanpei; Gradinger, Rolf Rudolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-21)

  The international and interdisciplinary sea-ice drift expedition “The Multidisciplinary drifting Observatory for the Study of Arctic Climate” (MOSAiC) was conducted from October 2019 to September 2020. The aim of MOSAiC was to study the interconnected physical, chemical, and biological characteristics and processes from the atmosphere to the deep sea of the central Arctic system. The ecosystem team ...
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  Biomarker endpoints in cancer cachexia clinical trials: Systematic Review 5 of the cachexia endpoint series 

  Yule, Michael S.; Thompson, Joshua; Leesahatsawat, Khachonphat; Sousa, Mariana S.; Anker, Stefan D.; Arends, Jann; Balstad, Trude Rakel; Brown, Leo R.; Bye, Asta; Dajani, Olav; Fallon, Marie; Hjermstad, Marianne Jensen; Jakobsen, Gunnhild; McDonald, James; McGovern, Josh; Roeland, Eric J.; Sayers, Judith; Skipworth, Richard J.E.; Ottestad, Inger; Philips, Iain; Simpson, Melanie Rae; Solheim, Tora S; Vagnildhaug, Ola Magne; McMillan, Donald; Laird, Barry J; Dolan, Ross D. (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-23)

  Regulatory agencies require evidence that endpoints correlate with clinical benefit before they can be used to approve drugs. Biomarkers are often considered surrogate endpoints. In cancer cachexia trials, the measurement of biomarkers features frequently. The aim of this systematic review was to assess the frequency and diversity of biomarker endpoints in cancer cachexia trials. A comprehensive ...

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