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  CALCOCO1 acts with VAMP ‐associated proteins to mediate ER ‐phagy 

  Nthiga, Thaddaeus Mutugi; Shrestha, Birendra Kumar; Sjøttem, Eva; Bruun, Jack-Ansgar; Larsen, Kenneth Bowitz; Bhujabal, Zambarlal; Lamark, Trond; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-11)

  The endoplasmic reticulum (ER) plays important roles in protein synthesis and folding, and calcium storage. The volume of the ER and expression of its resident proteins are increased in response to nutrient stress. ER‐phagy, a selective form of autophagy, is involved in the degradation of the excess components of the ER to restore homeostasis. Six ER‐resident proteins have been identified as ER‐phagy ...
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  Photonic-chip assisted correlative light and electron microscopy 

  Tinguely, Jean-Claude; Steyer, Anna Maria; Øie, Cristina Ionica; Helle, Øystein Ivar; Dullo, Firehun Tsige; Olsen, Randi; McCourt, Peter; Schwab, Yannick; Ahluwalia, Balpreet Singh (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-07)

  Correlative light and electron microscopy (CLEM) unifies the versatility of light microscopy (LM) with the high resolution of electron microscopy (EM), allowing one to zoom into the complex organization of cells. Here, we introduce photonic chip assisted CLEM, enabling multi-modal total internal reflection fluorescence (TIRF) microscopy over large field of view and high precision localization of the ...
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  Biomarkers of major bleeding after incident venous thromboembolism 

  Johnsen, Håkon Sandbukt (Doctoral thesis; Doktorgradsavhandling, 2021-03-23)

  Major bleeding (MB) events are feared and potentially fatal complications of anticoagulant treatment in patients with venous thromboembolism (VTE). Even though several clinical risk factors are associated with MB risk, the predictive power of currently available risk assessment models remain limited for VTE. The aim of this thesis was to identify biomarkers of MB risk during the first year after an ...
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  In-Silico Evaluation of Glucose Regulation Using Policy Gradient Reinforcement Learning for Patients with Type 1 Diabetes Mellitus 

  Myhre, Jonas Nordhaug; Tejedor Hernandez, Miguel Angel; Launonen, Ilkka Kalervo; El Fathi, Anas; Godtliebsen, Fred (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-11)

  In this paper, we test and evaluate policy gradient reinforcement learning for automated blood glucose control in patients with Type 1 Diabetes Mellitus. Recent research has shown that reinforcement learning is a promising approach to accommodate the need for individualized blood glucose level control algorithms. The motivation for using policy gradient algorithms comes from the fact that adaptively ...
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  The relation of gender role attitudes with depression and generalised anxiety disorder in two Russian cities 

  Jaehn, Phillip; Bobrova, Natalia; Saburova, Lyudmila; Kudryavtsev, Alexander V; Malyutina, Sofia; Cook, Sarah Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-08)

  <i>Background</i> - Reported traditional gender role attitudes (GRAs) have been related to worse mental health in western countries. This study examined the link of GRAs with symptoms of depression and generalised anxiety disorder (GAD) in two Russian cities.<br><br> <i>Methods</i> - We used interview data from the cross-sectional Know Your Heart Study conducted among 5099 adults aged 35-69 in ...

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