• DNA binding with a minimal scaffold: structure-function analysis of Lig E DNA ligases 

    Williamson, Adele Kim; Grgic, Miriam; Leiros, Hanna-Kirsti S. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-11)
    DNA ligases join breaks in the phosphodiester backbone of DNA by catalysing the formation of bonds between opposing 5′P and 3′OH ends in an adenylation-dependent manner. Catalysis is accompanied by reorientation of two core domains to provide access to the active site for cofactor utilization and enable substrate binding and product release. The general paradigm is that DNA ligases engage their DNA ...
  • Evaluation of feature ranking and regression methods for oceanic chlorophyll-a estimation 

    Blix, Katalin; Eltoft, Torbjørn (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-22)
    This paper evaluates two alternative regression techniques for oceanic chlorophyll-a (Chl-a) content estimation. One of the investigated methodologies is the recently introduced Gaussian process regression (GPR) model. We explore two feature ranking methods derived for the GPR model, namely sensitivity analysis (SA) and automatic relevance determination (ARD). We also investigate a second ...
  • The Role of Estrogen Receptor β (ERβ) in the Establishment of Hierarchical Social Relationships in Male Mice 

    Nakata, Mariko; Ågmo, Anders j; Satoshi, Shoko; Ogawa, Sonoko (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-22)
    Acquisition of social dominance is important for social species including mice, for preferential access to foods and mates. Male mice establish social rank through agonistic behaviors, which are regulated by gonadal steroid hormone, testosterone, as its original form and aromatized form. It is well known that estrogen receptors (ERs), particularly ER α (ERα), mediate effects of aromatized testosterone, ...
  • On the Isotypic Decomposition of Cohomology Modules of Symmetric Semi-algebraic Sets: Polynomial Bounds on Multiplicities 

    Basu, Saugata; Riener, Cordian (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-30)
    We consider symmetric (under the action of products of finite symmetric groups) real algebraic varieties and semi-algebraic sets, as well as symmetric complex varieties in affine and projective spaces, defined by polynomials of degrees bounded by a fixed constant <i>d</i>. We prove that if a Specht module, S<sup>λ</sup>⁠, appears with positive multiplicity in the isotypic decomposition of the ...
  • Making New Health Services Work: Nurse Leaders as Facilitators of Service Development in Rural Emergency Services 

    Hjertstrøm, Helle Kise; Obstfelder, Aud; Norbye, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-27)
    Nurse leaders in middle management positions in Norway and other Western countries perform additional new tasks due to high demands for quality and efficacy in healthcare services. These nurses are increasingly becoming responsible for service development and innovation in addition to their traditional leadership and management roles. This article analyses two Norwegian nurse leaders efforts in ...

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