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  Multi-scale modeling of drug binding kinetics to predict drug efficacy 

  Clarelli, Fabrizio; Liang, Jingyi; Martinecz, Antal; Heiland, Ines; Abel zur Wiesch, Pia (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-25)

  Optimizing drug therapies for any disease requires a solid understanding of pharmacokinetics (the drug concentration at a given time point in different body compartments) and pharmacodynamics (the effect a drug has at a given concentration). Mathematical models are frequently used to infer drug concentrations over time based on infrequent sampling and/or in inaccessible body compartments. Models are ...
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  Soil protist diversity in the Swiss western Alps is better predicted by topo-climatic than by edaphic variables 

  Seppey, Christophe Victor W.; Broennimann, Olivier; Buri, Aline; Yashiro, Erika; Pinto-Figueroa, Eric; Singer, David; Blandenier, Quentin; Mitchell, Edward A.D.; Niculita-Hirzel, Helene; Guisan, Antoine; Lara, Enrique (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-01)

  <i>Aim</i> - Trends in spatial patterns of diversity in macroscopic organisms can be well predicted from correlative models, using topo‐climatic variables for plants and animals allowing inference over large scales. By contrast, diversity in soil microorganisms is generally considered as mostly driven by edaphic variables and, therefore, difficult to extrapolate on a large spatial scale based on ...
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  A highly asymmetric gold(III) η3‐allyl complex 

  Holmsen, Marte Sofie; Nova, Ainara; Øien-Ødegaard, Sigurd; Heyn, Richard H.; Tilset, Mats (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-11)

  A highly asymmetric Au^III η³‐allyl complex has been generated by treating Au(η¹‐allyl)Br(tpy) (tpy=2‐(<i>p</i>‐tolyl)pyridine) with AgNTf₂. The resulting η³‐allyl complex has been characterized by NMR spectroscopy and X‐ray crystallography. DFT calculations and variable temperature ¹H NMR suggest that the allyl ligand is highly fluxional.
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  How can task shifting put patient safety at risk? A qualitative study of experiences among general practitioners in Norway 

  Malterud, Kirsti; Aamland, Aase; Fosse, Anette (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-23)

  <i>Objective</i>: To describe experiences among general practitioners (GPs) in Norway regarding horizontal task shifting experiences associated with adverse events that potentially put patient safety at risk.<p> <p><i>Design and contributors</i>: We conducted a qualitative study with data from a retrospective convenience sample of consecutive, already posted comments in a restricted Facebook group ...
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  Progress, traditions and future directions in research on disasters involving slow-onset hazards 

  Staupe-Delgado, Reidar (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-07)

  <i>Purpose</i> - The importance of onset speed has been stressed by disaster researchers and inter-governmental bodies for some time, but its meaning and knowledge frontier has not been explored in depth. The purpose of this paper is to contextualise disasters involving slow-onset hazards within the broader literature on disasters, assess the current state of knowledge and identify themes in the ...

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