• Rhodium-Catalyzed Hydrocarboxylation: Mechanistic Analysis Reveals Unusual Transition State for Carbon–Carbon Bond Formation 

  Pavlovic, Ljiljana; Vaitla, Janakiram; Bayer, Annette; Hopmann, Kathrin Helen (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-12)

  The mechanism of rhodium-COD-catalyzed hydrocarboxylation of styrene derivatives and α,β-unsaturated carbonyl compounds with CO₂ has been investigated using density functional theory (PBE-D2/IEFPCM). The calculations support a catalytic cycle as originally proposed by Mikami and co-workers including β-hydride elimination, insertion of the unsaturated substrate into a rhodium–hydride bond, ...
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  Mutational analysis of the pro-peptide of a marine intracellular subtilisin protease supports its role in inhibition 

  Bjerga, Gro Elin Kjæreng; Larsen, Øivind; ARSIN, Hasan; Williamson, Adele Kim; Garcia-Moyano, Antonio; Leiros, Ingar; Puntervoll, Pål (Journal article; Tidsskriftartikkel; Preprint; Manuskript, 2018-06-16)

  Intracellular subtilisin proteases (ISPs) have important roles in protein processing during the stationary phase in bacteria. Their unregulated protein degrading activity may have adverse effects inside a cell, but little is known about their regulatory mechanism. Until now, ISPs have mostly been described from <i>Bacillus</i> species, with structural data from a single homolog. Here, we study a ...
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  Systematic review of clinical and patient-reported outcomes following oral rehabilitation on dental implants with a tapered compared to a non-tapered implant design 

  Jokstad, Asbjørn; Ganeles, Jeffrey (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-17)

  <p><i>Background</i>: Dental implants are available in different shapes.</p> <p><i>Aims</i>: This systematic review aims to address whether tapered compared to non‐tapered implants demonstrate similar clinical and patient‐reported outcomes. The review follows the preferred reporting items for systematic reviews and meta‐analyses (PRISMA) format.</p> <p><i>Materials & Methods</i>: We searched ...
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  Local land use associated with socio-economic development in six arctic regions 

  Ehrich, Dorothee; Thuestad, Alma Elizabeth; Tømmervik, Hans; Fauchald, Per; Hausner, Vera Helene (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-04)

  The socioeconomic causes of land use change are complex. They are highly context dependent, but most often studied through case studies. Here, we use a quasi-experimental paired block design to investigate whether better access to wage income leads to more visible land use around 28 settlements in six regions of the circumpolar Arctic. We mapped visible land use on high-resolution satellite images ...
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  Drug permeability profiling using cell-free permeation tools: Overview and applications 

  Berben, Philippe; Bauer-Brandl, Annette; Brandl, Martin; Faller, Bernard; Flaten, Gøril Eide; Jacobsen, Ann-Cathrine; Brouwers, Joachim; Augustijns, Patrick (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-13)

  Cell-free permeation systems are gaining interest in drug discovery and development as tools to obtain a reliable prediction of passive intestinal absorption without the disadvantages associated with cell- or tissue-based permeability profiling. Depending on the composition of the barrier, cell-free permeation systems are classified into two classes including (i) biomimetic barriers which are ...

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