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  Deciphering Staphylococcus aureus–host dynamics using dual activity-based protein profiling of ATP-interacting proteins 

  Ahator, Stephen Dela; Hegstad, Kristin; Lentz, Christian Stephan; Johannessen, Mona Susan (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-24)

  The utilization of ATP within cells plays a fundamental role in cellular processes that are essential for the regulation of host–pathogen dynamics and the subsequent immune response. This study focuses on ATP-binding proteins to dissect the complex interplay between Staphylococcus aureus and human cells, particularly macrophages (THP-1) and keratinocytes (HaCaT), during an intracellular infection. ...
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  A city-scale turbulence-resolving model as an essential element of integrated urban services. 

  Esau, Igor; Belda, Michal; Miles, Victoria; Geletič, Jan; Resler, Jaroslav; Krč, Pavel; Bauerova, Petra; Bures, Martin; Eben, Krystof; Fuka, Vladimir; Jares, Radek; Karel, Jan; Keder, Josef; Patino, William; Pettersson, Lasse H; Radovic, Jelena; Reznicek, Hynek; Sindelarova, Adriana; Vlcek, Ondrej (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-07-11)

  Large-eddy simulation (LES) models, such as the PALM modeling system in this study, are actively used for urban micro-climate modeling. We consider urban LES in a broader context as a mature high-resolution model for integrated urban services (IUS), which is an initiative of the World Meteorological Organization that provides a modeling component for urban decision-support systems. A decision-support ...
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  DNA ploidy and PTEN as biomarkers for predicting aggressive disease in prostate cancer patients under active surveillance 

  Cyll, Karolina Urszula; Haug, Erik Skaaheim; Pradhan, Manohar; Vlatkovic, Ljijana; Carlsen, Birgitte; Löffeler, Sven; Kildal, Wanja; Skogstad, Karin; Torkelsen, Frida Hauge; Syvertsen, Rolf Anders; Askautrud, Hanne Arenberg; Liestøl, Knut; Kleppe, Andreas; Danielsen, Håvard Emil Greger (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-07-03)

  Background: Current risk stratification tools for prostate cancer patients under active surveillance (AS) may inadequately identify those needing treatment. We investigated DNA ploidy and PTEN as potential biomarkers to predict aggressive disease in AS patients.<p><p> Methods: We assessed DNA ploidy by image cytometry and PTEN protein expression by immunohistochemistry in 3197 tumour-containing ...
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  Physiological basis for atmospheric methane oxidation and methanotrophic growth on air 

  Schmider, Tilman John Siegfried; Hestnes, Anne Grethe; Brzykcy, Julia; Schmidt, Hannes; Schintlmeister, Arno; Roller, Benjamin; Teran, Ezequiel Jesús; Söllinger, Andrea; Schmidt, Oliver; Polz, Martin; Richter, Andreas; Svenning, Mette Marianne; Tveit, Alexander Tøsdal (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-16)

  Atmospheric methane oxidizing bacteria (atmMOB) constitute the sole bio-logical sink for atmospheric methane. Still, the physiological basis allowing atmMOB to grow on air is not well understood. Here we assess the ability and strategies of seven methanotrophic species to grow with air as sole energy, carbon, and nitrogen source. Four species, including three outside the canonical atmMOB group USCα, ...
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  Essential omega-3 fatty acids are depleted in sea ice and pelagic algae of the Central Arctic Ocean 

  Schmidt, Katrin; Graeve, Martin; Hoppe, Clara J. M.; Torres-Valdes, Sinhué; Welteke, Nahid; Whitmore, Laura M.; Anhaus, Philipp; Atkinson, Angus; Belt, Simon T.; Brenneis, Tina; Campbell, Robert G.; Castellani, Giulia; Copeman, Louise A.; Flores, Hauke; Fong, Allison A.; Hildebrandt, Nicole; Kohlbach, Doreen; Nielsen, Jens M.; Parrish, Christopher C.; Rad-Menéndez, Cecilia; Rokitta, Sebastian D.; Tippenhauer, Sandra; Zhuang, Yanpei (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-19)

  Microalgae are the main source of the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), essential for the healthy development of most marine and terrestrial fauna including humans. Inverse correlations of algal EPA and DHA proportions (% of total fatty acids) with temperature have led to suggestions of a warming-induced decline in the global production of these biomolecules ...

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