Recent additions

  • High expression of miR-17-5p in tumor epithelium is a predictor for poor prognosis for prostate cancer patients 

    Støen, Maria Jenvin; Andersen, Sigve; Rakaee, Mehrdad; Pedersen, Mona Irene; Ingebriktsen, Lise Martine; Bremnes, Roy M.; Dønnem, Tom; Lombardi, Ana Paola; Kilvær, Thomas Karsten; Rasmussen Busund, Lill-Tove; Richardsen, Elin (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-05)
    MicroRNAs (miRs) are small non-coding RNA molecules, which are involved in the development of various malignancies, including prostate cancer (PCa). miR-17-5p is considered the most prominent member of the miR-17-92 cluster, with an essential regulatory function of fundamental cellular processes. In many malignancies, up-regulation of miR-17-5p is associated with worse outcome. In PCa, miR-17-5p has ...
  • Combined Lifestyle Behaviors and the Incidence of Common Cancer Types in the Norwegian Women and Cancer Study (NOWAC) 

    Chen, Sairah Lai Fa; Braaten, Tonje Bjørndal; Borch, Kristin Benjaminsen; Ferrari, Pietro; Sandanger, Torkjel M; Nøst, Therese Haugdahl (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-16)
    <i>Introduction</i>: Only a small number of studies have examined the impact of combined lifestyle behaviors on cancer incidence, and never in a Norwegian population.<br><br> <i>Purpose</i>: To examine linear and nonlinear associations of combined lifestyle factors, assessed through a healthy lifestyle index (HLI), with the incidence of postmenopausal breast, colorectal, lung, postmenopausal ...
  • Treatment of cardiovascular dysfunction with PDE5-inhibitors - temperature dependent effects on transport and metabolism of cAMP and cGMP 

    Selli, Anders Lund; Kuzmiszyn, Adrina Kalasho; Smaglyukova, Natalia; Kondratiev, Timofei V.; Fuskevåg, Ole Martin; Lyså, Roy Andre; Ravna, Aina Westrheim; Tveita, Torkjel; Sager, Georg; Dietrichs, Erik Sveberg (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-30)
    <i>Introduction</i>: Cardiovascular dysfunction is a potentially lethal complication of hypothermia. Due to a knowledge gap, pharmacological interventions are not recommended at core temperatures below 30°C. Yet, further cooling is induced in surgical procedures and survival of accidental hypothermia is reported after rewarming from below 15°C, advocating a need for evidence-based treatment guidelines. ...
  • Role of Virus-Induced Host Cell Epigenetic Changes in Cancer 

    Pietropaolo, Valeria; Prezioso, Carla; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-03)
    The tumor viruses human T-lymphotropic virus 1 (HTLV-1), hepatitis C virus (HCV), Merkel cell polyomavirus (MCPyV), high-risk human papillomaviruses (HR-HPVs), Epstein-Barr virus (EBV), Kaposi’s sarcoma-associated herpes virus (KSHV) and hepatitis B virus (HBV) account for approximately 15% of all human cancers. Although the oncoproteins of these tumor viruses display no sequence similarity to one ...
  • Antenatal breastmilk expression for women with diabetes in pregnancy - a feasibility study 

    Johnsen, Maren; Klingenberg, Claus; Brand, Meta; Revhaug, Arthur; Andreassen, Gunnbjørg (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-23)
    <i>Background</i> - Mothers with diabetes are less likely to achieve successful breastfeeding. Antenatal breastmilk expression (ABE) may facilitate earlier breastfeeding, but feasibility of introducing ABE and its acceptance among Scandinavian women have previously not been investigated.<br><br> <i>Methods</i> - This observational trial was conducted between the 1 January 2019 and the 12 March ...
  • Community Violence Exposure and School Functioning in Youth: Cross-Country and Gender Perspectives 

    Koposov, Roman A; Isaksson, Johan; Vermeiren, Robert; Schwab-Stone, Mary; Stickley, Andrew; Ruchkin, Vladislav (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-27)
    <i>Background</i>: Many children and adolescents experience violent events which can be associated with negative consequences for their development, mental health, school, and social functioning. However, findings between settings and on the role of gender have been inconsistent. This study aimed to investigate cross-country and gender differences in the relationship between community violence ...
  • Myelomatose i Nord-Norge 2005-2015 

    Lauvås, Kenneth (Master thesis; Mastergradsoppgave, 2017-09-20)
    Bakgrunn: Myelomatose er den tredje vanligste hematologiske kreftsykdommen med en insidensrate på 6,5 per 100,000. Sykdommen kjennetegnes av akkumulering av plasmaceller i beinmargen, og utvikler seg alltid gjennom forstadiet MGUS. Symptomene er lite spesifikke og diagnostikken er omfattende. Myelomatose meldes til kreftregisteret, men kreftregisteret publiserer ikke overlevelsesdata for landet som ...
  • Dioxin-like activity in blood from women with breast cancer and their age-matched controls 

    Nedrebø, Lise Custers (Master thesis; Mastergradsoppgave, 2017-09-20)
    Breast cancer is the most common cancer in women today, and although many risk factors are known, these cannot fully explain the vast increase in breast cancer incidences the last decades. Persistent organic pollutants have been indicated as potential carcinogenic compounds and it is therefore interesting to see if they can be a factor in the development of the disease. Here, we assessed the ...
  • When is remission remission? Elucidating the remission state in Ulcerative Colitis: a multimodal exploration 

    Arkteg, Christian Børde (Doctoral thesis; Doktorgradsavhandling, 2021-10-22)
    Ulcerative Colitis (UC) is a chronic, inflammatory disease of the colon that has a relapsing-remitting characteristic. The disease management consists of prolonging periods of remission and reducing relapse frequency. There is currently no universally accepted definition of remission in UC. There are different methods of establishing if a patient is in remission, but the lack of definition and ...
  • Systematisk oversikt over sykestueforskning med vekt på kvalitet, økonomi og pasientforløp 

    Nilsen, Karoline Damsgård (Master thesis; Mastergradsoppgave, 2017-09-17)
    Introduksjon: Samhandlingsreformen og den nye helse- og omsorgstjenesteloven påla alle kommuner å opprette øyeblikkelig hjelp døgntilbud fra 1.1.2016. Intermediærenheter som sykestuer har de siste tiårene fått økende fokus både i Norge og i utlandet. Målet med denne oppgaven er å lage en systematisk oversikt over forskningslitteratur som omhandler sykestuer med vekt på kvalitet, økonomi og ...
  • The use of commercial ELISA kits in measuring CA6 concentration of saliva 

    Machlik, Edit; Woll, Emilie Elise (Mastergradsoppgave; Master thesis, 2021-05-20)
    Introduction: Carbonic anhydrase 6 (CA6) is the only secreted member of the carbonic anhydrase enzyme family. This enzyme catalyzes the reversible hydration of carbon dioxide: CO2 + H2O ⇔ H+ + HCO3-. The dehydration reaction contributes to net acidification in several tissues and biological fluids. Salivary CA6 attaches to the enamel and predisposes to caries probably by acidifying the dental biofilm ...
  • Selecting stimulation intensity in repetitive transcranial magnetic stimulation studies: A systematic review between 1991 and 2020 

    Turi, Zsolt; Lenz, Maximilian; Paulus, Walter; Mittner, Matthias; Vlachos, Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-22)
    Repetitive transcranial magnetic stimulation (rTMS) is an increasingly used, non-invasive brain stimulation technique in neuroscience research and clinical practice with a broad spectrum of suggested applications. Among other parameters, the choice of stimulus intensity and intracranial electric field strength substantially impacts rTMS outcome. This review provides a systematic overview of the ...
  • Advanced methods in reproductive medicine: Application of optical nanoscopy, artificial intelligence-assisted quantitative phase microscopy and mitochondrial DNA copy numbers to assess human sperm cells 

    Popova, Daria (Doctoral thesis; Doktorgradsavhandling, 2021-10-22)
    Declined fertility rate and population is a matter of serious concern, especially in the developed nations. Assisted Reproductive Technologies (ART), including in vitro fertilization (IVF), have provided great hope for infertility treatment and maintaining population growth and social structure. With the help of ART, more than 8 million babies have already been born so far. Despite the worldwide ...
  • Oral health and use of dental services in different stages of adulthood in Norway: a cross sectional study 

    Hadler-Olsen, Elin Synnøve; Jönsson, Birgitta (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-13)
    <i>Background</i> - Socioeconomic status and oral health care habits may change throughout adult life. This calls for age-stratified analyses of oral health in the adult population to uncover differences that could be of importance for organizing adequate oral health care services. The aim of the present study was to describe self-reported oral health in different age groups in a general adult ...
  • Validating Acute Myocardial Infarction Diagnoses in National Health Registers for Use as Endpoint in Research: The Tromsø Study 

    Varmdal, Torunn; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Njølstad, Inger; Nyrnes, Audhild; Grimsgaard, Sameline; Bønaa, Kaare Harald; Mannsverk, Jan; Løchen, Maja-Lisa (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-03)
    <i>Purpose</i>: To assess whether acute myocardial infarction (MI) diagnoses in national health registers are sufficiently correct and complete to replace manual collection of endpoint data for a population-based, epidemiological study.<br><br> <i>Patients and Methods</i>: Using the Tromsø Study Cardiovascular Disease Register for 2013– 2014 as gold standard, we calculated correctness (defined ...
  • Symptoms and signs of colorectal cancer, with differences between proximal and distal colon cancer: a prospective cohort study of diagnostic accuracy in primary care 

    Holtedahl, Knut; Borgquist, Lars; Donker, Gé A.; Buntinx, Frank; Weller, David; Campbell, Christine; Månsson, Jörgen; Hammersley, Victoria; Braaten, Tonje; Parajuli, Ranjan (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-08)
    <i>Background</i> - In an abdominal symptom study in primary care in six European countries, 511 cases of cancer were recorded prospectively among 61,802 patients 16 years and older in Norway, Denmark, Sweden, Netherlands, Belgium and Scotland. Colorectal cancer is one of the main types of cancer associated with abdominal symptoms; hence, an in-depth subgroup analysis of the 94 colorectal cancers ...
  • Risk of cervical intraepithelial neoplasia grade 3 or higher (CIN3+) among women with HPV-test in 1990–1992, a 30-year follow-up study 

    Riibe, Marit Østlyngen; Sørbye, Sveinung Wergeland; Simonsen, Gunnar Skov; Sundsfjord, Arnfinn; Ekgren, Josef; Maltau, Jan Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-22)
    <i>Background/objective</i> - Having a 30-year follow-up of a cohort of women tested for HPV is a unique opportunity to further study long-term risk of CIN3+. The study objective was to compare HPV status at baseline with the risk of CIN3+ in the follow-up period of 30 years.<br><br> <i>Methods</i> - All women (n = 642) referred to the HPV outpatient clinic at the University Hospital of North ...
  • Ginseng for Erectile Dysfunction: A Cochrane Systematic Review 

    Lee, Hye Won; Lee, Myeong Soo; Kim, Tae-Hun; Alræk, Terje; Zaslawski, Chris; Kim, Jong Wook; Moon, Du Geon (Journal article; Tidsskriftartikkel; Peer reviewed, 2021)
    The objectives of this study were to assess the effects of ginseng on erectile dysfunction. We searched multiple electronic databases from their inceptions to 30 January 2021 without restrictions by language. We included randomized or quasirandomized controlled trials that evaluated the use of any type of ginseng as a treatment for erectile dysfunction compared to placebo or conventional treatment. ...
  • Development of 8f-labeled radiotracers for pet imaging of the adenosine a2a receptor: Synthesis, radiolabeling and preliminary biological evaluation 

    Lai, Thu Hang; Schröder, Susann; Toussaint, Magali; Dukić-Stefanović, Sladjana; Kranz, Mathias; Ludwig, Friedrich-Alexander; Fischer, Steffen; Steinbach, Jörg; Deuther-Conrad, Winnie; Brust, Peter; Moldovan, Rareş-Petru (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-25)
    The adenosine A<sub>2A</sub> receptor (A<sub>2A</sub>R) represents a potential therapeutic target for neurodegenerative diseases. Aiming at the development of a positron emission tomography (PET) radiotracer to monitor changes of receptor density and/or occupancy during the A<sub>2A</sub>R-tailored therapy, we designed a library of fluorinated analogs based on a recently published lead compound ...
  • Validity and responsiveness of EQ-5D-5L and SF-6D in patients with health complaints attributed to their amalgam fillings: a prospective cohort study of patients undergoing amalgam removal 

    Lamu, Admassu N.; Björkman, Lars; Hamre, Harald Johan; Alræk, Terje; Musial, Frauke; Robberstad, Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-17)
    <i>Background</i> - Evidence of health utility changes in patients who suffer from longstanding health complaints attributed to dental amalgam fillings are limited. The change in health utility outcomes enables calculating quality-adjusted life-year (QALY) and facilitates the comparison with other health conditions. The purpose of this study was to estimate the validity and responsiveness of the ...

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