Recent additions

  • Elevating Safe Use of Over-The-Counter Medications in Older Adults: A Narrative Review of Pharmacy Involved Interventions and Recommendations for Improvement 

    Lehnbom, Elin; Berbakov, Maria E.; Hoffins, Emily L.; Moon, Jukrin; Welch, Lauren; Chui, Michelle A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-20)
    Over-the-counter (OTC) medications are products that have been made easily accessible to allow patients to treat common ailments without a prescription and the cost of a doctor’s visit. These medications are generally considered safe; however, there is still a potential for these medications to lead to adverse health outcomes. Older adults (ages 50+) are especially susceptible to these adverse health ...
  • Utvikling av utskrivningsintervensjon med fokus på riktig legemiddelbruk – en kvalitetsforbedringsstudie ved medisinsk avdeling 

    Garcia, Beate Hennie; Aag, Trine Iversen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023)
    Hensikt - Hensikten med studien var å utvikle en utskrivningsintervensjon med fokus på riktig legemiddelbruk etter sykehusopphold. Involvering av farmasøyt var en forutsetning.<p> <p>Metode - Ved hjelp av forbedringsmetodikken plan-do-study-act (PDSA) har vi utviklet og evaluert en utskrivningsintervensjon hvor farmasøyten er sentral i samarbeid med det tverrfaglige teamet.<p> <p>Resultater - ...
  • Novel insights into the fenestrated scavenger endothelium of the liver sinusoid 

    Holte, Christopher Florian (Doctoral thesis; Doktorgradsavhandling, 2024-03-22)
    <p>The sinusoids (specialized small blood vessels) of the liver are covered by endothelium (blood vessel wall cells) with open transcellular pores (holes that go from one side to the other) called fenestrations. This allows for efficient bidirectional transfer of solutes between the blood and the hepatocytes (main metabolic liver cell). These fenestrations can disappear or reduce in number and size ...
  • CaMKIIa+ neurons in the bed nucleus of the stria terminalis modulate pace of natural reward seeking depending on internal state 

    Huijgens, Patty Thalia; Heijkoop, Roy; Vanderschuren, Louk; Lesscher, Heidi; Snoeren, Eelke Mirthe Simone (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-24)
    This study aims to investigate the underlying neurobiological mechanisms that regulate natural reward seeking behaviors, specifically in the context of sexual behavior and sucrose self-administration. The role of CaMKIIa+neurons in the bed nucleus of the stria terminalis (BNST) was explored using chemogenetic silencing and -stimulation. Additionally, the study examined how these effects ...
  • Evaluering av pilotprosjekt med primærhelseteam og alternative finansieringsordninger. Statusrapport I 

    Abelsen, Birgit; Gaski, Margrete; Godager, Geir; Iversen, Tor; Løyland, Hanna Isabel; Pedersen, Kine; Sten-gahmberg, Susanna; Sæther, Erik Magnus (Research report; Forskningsrapport, 2019)
    Fra 1. april 2018 prøves primærhelseteam ut som en organisasjonsform med teamorganisering og to alternative finansieringsmodeller ved 13 fastlegekontor i ni kommuner. Forsøket administreres av Helsedirektoratet og skal pågå i tre år. Forsøket evalueres av en samarbeidskonstellasjon av forskere fra Universitetet i Oslo, Universitetet i Tromsø og Oslo Economics. I denne rapporten beskriver vi status ...
  • Dritbra» hvis ungdom gir oss avføringen sin 

    Pettersen, Veronika Kucharová; Kloos, Julia Maria (Others; Andre, 2024-02-17)
    En forskningsgruppe ved UiT samler inn avføring fra barn og unge for å studere tarmbakterier. Målet er å utvikle bedre diagnoser for sykdommer og oppdage lidelser tidligere, ifølge medisinstudent Ole Martin Ellingsbø Nilsen. Prosjektet har fått økonomisk støtte fra Barnekreftforeningen og rekrutteringshjelp fra Tromsø kommune. Ungdommer som deltar får en «kit» for å samle inn prøvene, samt ...
  • Poorer self-reported mental health and general health among first year upper secondary school students do not predict school dropout: a five-year prospective study 

    Goll, Charlotte Bjørnskov; Sørlie, Tore; Friborg, Oddgeir; Ottosen, Karl-Ottar; Sæle, Rannveig Grøm (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-08)
    Introduction: Education is important for socioeconomic, work and health status; thus, dropping out of secondary school is of major concern. In Norway, 1 out of 5 is dropping out from upper secondary education. Academic performance is a known predictor for dropout, but the role of mental and general health status is studied less.<p> <p>Methods: By use of student data collected during the first ...
  • Rapport - Workshop om fremtidens skredopplæring 

    Dassler, Tim; Skille, Tarjei Tveito; Pfuhl, Gerit; Fjellaksel, Richard (Research report; Forskningsrapport, 2023)
    2. november 2023 gjennomførte Norskred i samarbeid med Nortind, Den norske turistforeningen (DNT), Norsk fjellsportforum (NF) og UiT CARE – senter for snøskredforskning en workshop om fremtidens skredopplæring i Norge. Workshopen ble arrangert dagen før den nordiske skredkonferansen 2023 på Oppdal.<p> <p>Dagens modell for skredopplæring inneholder mange læringsmål og en kursstige som virker å ...
  • The first tigecycline resistant Enterococcus faecium in Norway was related to tigecycline exposure 

    Hegstad, Kristin; Pöntinen, Anna Kaarina; Bjørnholt, Jørgen; Paulsen, Else Quist; Sundsfjord, Arnfinn Ståle (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-19)
    Objectives - We describe the first tigecycline resistant enterococcal isolate in Norway and the mechanisms involved.<p> <p>Material and methods - The Norwegian National Advisory Unit on Detection of Antimicrobial Resistance (K-res). received in 2022 an Enterococcus faecium blood culture isolate with decreased susceptibility to tigecycline from a hospitalized patient in the South-Eastern Norway ...
  • Transition From Substance-Induced Psychosis to Schizophrenia Spectrum Disorder or Bipolar Disorder 

    Rognli, Eline B.; Heiberg, Ina Heidi; Jacobsen, Bjarne Koster; Høye, Anne; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-03)
    Objective: The authors investigated transitions to schizophrenia spectrum or bipolar disorder following different types of substance-induced psychosis and the impact of gender, age, number of emergency admissions related to substance-induced psychosis, and type of substance-induced psychosis on such transitions. <p> <p>Methods: All patients in the Norwegian Patient Registry with a diagnosis of ...
  • Redefining clinical venous thromboembolism phenotypes: a novel approach using latent class analysis 

    de Winter, Maria A.; Uijl, Alicia; Büller, Harry R.; Carrier, Marc; Cohen, Alexander T.; Hansen, John Bjarne; Kaasjager, Karin H.A.H.; Kakkar, Ajay K.; Middeldorp, Saskia; Raskob, Gary E.; Sørensen, Henrik Toft; Wells, Philip S.; Nijkeuter, Mathilde; Dorresteijn, Jannick A.N. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-22)
    Background - Patients with venous thromboembolism (VTE) are commonly classified by the presence or absence of provoking factors at the time of VTE to guide treatment decisions. This approach may not capture the heterogeneity of the disease and its prognosis.<p> <p>Objectives - To evaluate clinically important novel phenotypic clusters among patients with VTE without cancer and to explore their ...
  • Medial Temporal Lobe Atrophy in Predementia Alzheimer's Disease: A Longitudinal Multi-Site Study Comparing Staging and A/T/N in a Clinical Research Cohort 

    Jarholm, Jonas Alexander; Bjørnerud, Atle; Dalaker, Turi Olene; Akhavi, Mehdi Sadat; Kirsebom, Bjørn-Eivind; Pålhaugen, Lene; Nordengen, Kaja; Grøntvedt, Gøril Rolfseng; Nakling, Arne Exner; Kalheim, Lisa Flem; Almdahl, Ina Selseth; Teceläo, Sandra Raquel Ramos; Fladby, Tormod; Selnes, Per (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-27)
    Background: Atrophy of the medial temporal lobe (MTL) is a biological characteristic of Alzheimer’s disease (AD) and can be measured by segmentation of magnetic resonance images (MRI). Objective: To assess the clinical utility of automated volumetry in a cognitively well-defined and biomarker-classified multi-center longitudinal predementia cohort. <p>Methods: We used Automatic Segmentation of ...
  • Vitamin D Status During Adolescence and the Impact of Lifestyle Changes: 2 Years’ Follow-up From the Fit Futures Study 

    Öberg, Eva Gunnel Johanna; Jorde, Rolf; Almås, Bjørg; Nielsen, Christopher Sivert; Gerds, Thomas Alexander; Cashman, Kevin D.; Grimnes, Guri (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-13)
    Context: Longitudinal data regarding vitamin D status in adolescence is scarce. This study presents population-based data from an Arctic adolescent population (n = 589) at 16 and 18 years. Objective: The aims of this study were to investigate changes in vitamin D status during 2 years in adolescence, and whether lifestyle changes were associated with serum 25-hydroxyvitamin D (s-25(OH)D) at follow-up. ...
  • In situ simulation training strengthened bachelor of nursing students’ experienced learning and development process– a qualitative study 

    Karlsen, Karina Synnøve Pedersen; Nygård, Carina; Johansen, Lisbeth Gaustad; Gjevjon, Edith Lillian Roth (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-15)
    Background In advanced clinical learning labs on campus, high-fidelity simulation has become an essential educational approach in the Bachelor of Nursing Education programme. However, simulation while in clinical placement, in situ, is rarely used in Bachelor of Nursing Education. The aim of the present study was to explore how in situ simulation training at a surgical hospital ward, according ...
  • Cytomegalovirus infection and dexamethasone effects in liver sinusoidal endothelial cells 

    Kyrrestad, Ingelin (Doctoral thesis; Doktorgradsavhandling, 2024-03-15)
    The liver is a major organ in the body's defense against blood-borne pathogens. It acts as a filter for the blood and is a central site for immune responses, and a central hub for various metabolic processes. Within the liver, an extensive network of small blood vessels, the hepatic sinusoids, are key sites for the exchange of nutrients and waste products between the blood circulation and the liver ...
  • Homology Modeling of Transporter Proteins 

    Sylte, Ingebrigt; Gabrielsen, Mari; Kristiansen, kurt (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-24)
    Membrane transporter proteins are divided into channels/pores and carriers and constitute protein families of physiological and pharmacological importance. Several presently used therapeutic compounds elucidate their effects by targeting membrane transporter proteins, including anti-arrhythmic, anesthetic, antidepressant, anxiolytic and diuretic drugs. The lack of three-dimensional structures of ...
  • Because sex matters: The case of female sexual response 

    Ventura-Aquino, Elisa; Ågmo, Anders j (Chapter; Bokkapittel, 2023-05-17)
    In recent years, the Food and Drug Administration approved two drugs for the treatment of hypoactive sexual desire disorder in premenopausal women which have been tested in preclinical tests with positive effects on some appetitive sexual behavior in female rats. Some years after their commercial release, the effectiveness of both drugs in women is not clear. In the present chapter, we present some ...
  • Exploring stakeholders' perspectives on the quality of services provided through community pharmacies 

    Jakobsen, Ann Helen; Småbrekke, Lars; Chen, Timothy F.; Halvorsen, Kjell H. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-02)
    Introduction - It is important to understand the factors impacting the quality of services provided through community pharmacies. Exploring how key stakeholders perceive good quality in these services is a logical first step. This could also inform the development of quality measures, such as quality indicators (QIs).<p> <p>Aim - To identify key stakeholders' perspectives on the quality of services ...
  • Artificial intelligence-supported screen reading versus standard double reading in the Mammography Screening with Artificial Intelligence trial (MASAI): a clinical safety analysis of a randomised, controlled, non-inferiority, single-blinded, screening accuracy study 

    Lång, Kristina; Josefsson, Viktoria; Larsson, Anna-Maria; Larsson, Stefan; Högberg, Charlotte; Sartor, Hanna; Hofvind, Solveig Sand-Hanssen; Andersson, Ingvar; Rosso, Aldana (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-01)
    Background - Retrospective studies have shown promising results using artificial intelligence (AI) to improve mammography screening accuracy and reduce screen-reading workload; however, to our knowledge, a randomised trial has not yet been conducted. We aimed to assess the clinical safety of an AI-supported screen-reading protocol compared with standard screen reading by radiologists following ...
  • Optimizing the Pairs of Radiologists That Double Read Screening Mammograms 

    Gommers, Jessie J.J.; Abbey, Craig K.; Strand, Fredrik; Taylor-Phillips, Sian; Jenkinson, David J.; Larsen, Marthe; Hofvind, Solveig Sand-Hanssen; Sechopoulos, Ioannis; Broeders, Mireille J.M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-24)
    Performance characteristics of mammography readers influenced the performance of pairs, but specific pairing strategies did not result in significantly different overall performance compared with that resulting from random pairing strategies.<p> <p>Background - Despite variation in performance characteristics among radiologists, the pairing of radiologists for the double reading of screening ...

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