Recent additions

  • Molekylmodelleringsstudium av G-protein koblet østrogenreseptor (GPER) 

    Smith, Maria (Mastergradsoppgave; Master thesis, 2017-05-15)
    G-protein koblet østrogenreseptor (GPER) har vist å ha en fysiologisk rolle i det reproduktive systemet, nervesystemet, endokrine systemet, immunsystemet og karsystemet. Den har også patofysiologisk rolle i flere forskjellige sykdommer inkludert kreft. G-protein koblet østrogenreseptor har blitt identifisert i nesten alle systemer i kroppen. Dermed er det en stor interesse for å få kjennskap til ...
  • The search of new negative allosteric GABAB receptor modulators using in silico and in vitro approaches 

    Hadi, Ali Muataz (Mastergradsoppgave; Master thesis, 2020-05-14)
    γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the CNS. GABA exerts its function on both ionotropic ligand-gated GABAA receptors and metabotropic GABAB G-protein coupled receptors (GPCRs). Disruption in the GABAergic system has been associated with numerous neurological and psychiatric disorders in humans. These include developmental dysfunctions, epilepsy, sleep disorders, ...
  • Microfluidized liposomes for cellular uptake imaging: Optimization 

    Mork, Silje (Mastergradsoppgave; Master thesis, 2020-05-14)
    Liposomes as drug delivery systems exhibit great potential to deliver active molecules to the targeted site depending on their various characteristics. However, these characteristics are dependent on the manufacturing procedures applied to prepare liposomes. Especially difficult is assurance of reproducible production in large volumes. Therefore an efficient up-scalable method for production of ...
  • Bruk av antibakterielle midler blant barn 0-3 år etter fødselssesong og fødselsår i Norge 2004-2017 

    Beckstrøm, Sanna (Mastergradsoppgave; Master thesis, 2019-05-14)
    Bakgrunn: Ettårig periodeprevalens for bruk av antibakterielle midler til barn i Norge er høyest før tre års alder. Forskriving av antibakterielle midler påvirkes av mange faktorer, og kartlegging av disse kan gi mulighet til å målrette intervensjoner for å redusere forskriving. Formål: De primære målene var å undersøke om fødselssesong predikerer alder ved første utlevering av antibakterielle midler, ...
  • Electrospinning of nanofibers with chitosan and B-glucan as active wound healing ingredients: Optimization and characterization 

    Olaussen, Julie Wik (Mastergradsoppgave; Master thesis, 2020-05-14)
    Wound healing is a complex and highly regulated process, vital for preserving the barrier function of the skin. However, several underlying pathologies have the ability to influence the cascade of events involved in this process, resulting in the development of chronic wounds. The heterogeneous nature of chronic wounds increases the requirements of novel wound dressings. Hence, the development of ...
  • High throughput lipolysis-permeation in vitro model employing the mucus-PVPA barriers to assess drug absorption from lipid-based delivery systems 

    Brurok, Sunniva (Mastergradsoppgave; Master thesis, 2020-05-14)
    In vitro lipolysis models are commonly used to assess the performance of lipid-based drug delivery systems (LbDDSs) in terms of their drug absorption potential; however, this in vitro approach has not always shown to correlate well with in vivo data. Several studies suggest that adding an absorption step to the in vitro lipolysis model would give a better estimation of absorption for drugs incorporated ...
  • Characterization of commensal enterococcal membrane vesicles and their cytotoxic effect on various host cells 

    Bhandari, Ishan (Mastergradsoppgave; Master thesis, 2020-05-14)
    Enterococcus are a group of bacteria growing on different environmental condition behaving as a commensal as well as opportunistic pathogen. Among the enterococci, Enterococcus faecium is recently emerged as a nosocomial multi-resistance pathogen especially in the severely ill and immunocompromised patients causing a wide range of diseases like endocarditis, bacteraemia and urinary tract infections. ...
  • Virtual screening and in vitro evaluation of putative positive allosteric modulators of the GABAB receptor 

    Issifou, Ibrahim Toure (Mastergradsoppgave; Master thesis, 2020-05-14)
    -aminobutyric acid (GABA) is the chief inhibitory neurotransmitter of the central nervous system (CNS). GABA exhibits its function by binding to either the ionotropic GABAA receptor or the metabotropic GABAB receptor, causing a decrease in activity in the nervous system. Disruption in the GABAergic system has been associated with various neurological conditions, including Alzheimer’s disease, anxiety, ...
  • Success and failure in eHealth 

    Janssen, Wouter (Mastergradsoppgave; Master thesis, 2017-05-14)
    Introduction In the field of eHealth, there seems to be a gap between promising research and clinical reality. This master thesis aims to give insight in patterns that can be found regarding the possible outcome in terms of success and/or failure. An in-depth review of workflow will be done, to get an understanding of the implications of eHealth on workflow. Methods Using a systematic article ...
  • Expression and characterization of recombinant murine integrin β3 modified to express the human platelet antigen-1a epitope 

    Rasmussen, Trude Victoria (Mastergradsoppgave; Master thesis, 2017-05-14)
    Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a condition where the mother produces alloantibodies against fetal platelets during pregnancy most commonly due to an incompatibility in the human platelet antigen (HPA)-1 system; a single amino acid polymorphism located on integrin β3 with two common variants, HPA-1a and HPA-1b. Antibody responses against HPA-1a can be formed in women who ...
  • Optimising breast reconstruction. A clinical study on autologous breast reconstruction 

    Sjöberg, Thomas K. (Doctoral thesis; Doktorgradsavhandling, 2022-06-03)
    Denne avhandlingen omhandler metoder for å optimalisere utfallet av brystrekonstruksjon ved bruk av kroppseget vev. Det første delarbeidet beskriver en kirurgisk teknikk som kombinerer to lapper fra henholdsvis buken (DIEP og TRAM lapper) og ytre deler av brystkassen (LICAP lapp) for å oppnå større volum og penere fasong på det rekonstruerte brystet hos kvinner med lite overskuddsvev på buken. LICAP ...
  • Måleegenskaper ved den norske versjonen av The Children’s Communication Checklist - Second Edition (CCC-2) 

    Reindal, Lise; Brøndbo, Per Håkan; Jozefiak, Thomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-03)
    <p><b>Beskrivelse. </b>The Children’s Communication Checklist-Second Edition (CCC-2; Bishop, 2003) kartlegger muntlig og pragmatisk språk hos barn i aldersgruppen 4:0–16:11 år. Norsk og internasjonal rettighetshaver er Pearson Assessment. Den norske oversettelsen er utført av Wenche Andersen Helland og Lillian Hollund-Møllerhaug med hjelp fra klinisk ekspertise, og ble ferdigstilt i 2011. ...
  • Disability pension dynamics in early adulthood: A two-decade longitudinal study of educational, work and welfare-state trajectories in Norway 

    Wittlund, Sina Marion; Mykletun, Arnstein; Lorentzen, Thomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-31)
    Background: Since the 1990’s, structural transformations in the Norwegian economy have decreased employment opportunities for low-skilled young people lacking formal education credentials. In parallel with these economic changes, there has been a strong increase in the proportion of young disability pensioners. Preventing labour market exit requires a thorough understanding of the disability ...
  • The relative spatial positions of tryptophan and cationic residues in helical membrane-active peptides determines their cytotoxicity 

    Rekdal, Øystein; Haug, Bengt Erik; Kalaaji, manar; Hunter, Howard N.; Lindin, Inger; Israelsson, Ingrid; Solstad, Terese; Yang, Nannan; Brandl, Martin; Mantzilas, Dimitrios; Vogel, Hans J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2011-11-04)
    Background: Tryptophan side chains can influence the binding of amphipathic peptides to biological membranes. <p>Results: The cytotoxic activity of model helical amphipathic peptides was markedly influenced by the positions of tryptophan residues in the sequence. <p>Conclusion: Tryptophan residues located adjacent to a hydrophobic helical portion created the most potent cytotoxic peptides. <p> ...
  • Fitness costs of various mobile genetic elements in Enterococcus faecium and Enterococcus faecalis 

    Starikova, Irina; Al-Haroni, Mohammed; Werner, Guido; Roberts, Adam P.; Nielsen, Kåre M.; Johnsen, Pål Jarle (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-07-05)
    Objectives: To determine the fitness effects of various mobile genetic elements (MGEs) in Enterococcus faecium and Enterococcus faecalis when newly acquired. We also tested the hypothesis that the biological cost of vancomycin resistance plasmids could be mitigated during continuous growth in the laboratory.<p> <p>Methods: Different MGEs, including two conjugative transposons (CTns) of the Tn916 ...
  • Importation of roughage to Norway - Implications for plant and animal health, zoonoses, and biodiversity. Opinion of the scientific committee of the Norwegian Scientific Committee for Food and Enviroment 

    Nesbakken, Truls; Steinshamn, Håvard; Thomsen, Iben Margrete; Basic, Dean; Klem, Thea B. Blystad; Gifstad, Tron Øystein; Kausrud, Kyrre Linné; Melby, Kjetil Klaveness; Kirkendall, Lawrence Richard; Magnusson, Christer; Måren, Inger Elisabeth; Nicolaisen, Mogens; Randby, Åshild Taksdal; Stokstad, Maria; Yazdankhah, Siamak Pour; Wendell, Per Hans Micael; Agdestein, Angelika; de Boer, Hugo; Godfroid, Jacques Xavier Leon; Jore, Solveig; Krokene, Paal; Nesse, Live Lingaas; Madslien, Knut; Møretrø, Trond; Velle, Gaute (Research report; Forskningsrapport, 2022-02-18)
    Det er stor usikkerhet om import av grovfôr til Norge kan føre med seg planteskadegjørere, invaderende planter og smittestoff som kan forårsake sykdom hos dyr og mennesker.
  • Single use negative-pressure wound therapy compared to standard care in patients after carbon dioxide laser surgery for hidradenitis suppurativa 

    Grimstad, Øystein (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-03)
    Negative pressure wound therapy is a commonly used treatment modality for surgi-cal wounds healing by secondary intention. In an open, split side study with12 patients, we compared low negative pressure wound therapy to conventionalfoam dressing the first postoperative week after carbon dioxide laser vaporization ofhidradenitis suppurativa lesions. The primary outcome was time to complete woundhealing, ...
  • Past Negative Consequences of Unnecessary Delay as a Marker of Procrastination 

    Svartdal, Frode; Nemtcan, Efim (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-21)
    Standard definitions of procrastination underscore the irrational nature of this habit, a critical criterion being that the procrastinating individual delays despite expecting to be worse off for the delay. However, an examination of more than 175 items in 18 procrastination scales reveals that they do not address such a forward-looking criterion. Consequently, scales run the risk of not separating ...
  • Crosstalk between p38 MAPK and GR Signaling 

    Zeyen Øyås, Lisa; Seternes, Ole Morten; Mikkola, Ingvild (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-19)
    The p38 MAPK is a signaling pathway important for cells to respond to environmental and intracellular stress. Upon activation, the p38 kinase phosphorylates downstream effectors, which control the inflammatory response and coordinate fundamental cellular processes such as proliferation, apoptosis, and differentiation. Dysregulation of this signaling pathway has been linked to inflammatory diseases ...
  • Vedvarende bruk av opioider og samtidig bruk av andre vanedannende legemidler 

    Odsbu, Ingvild; Handal, Marte; Hjellvik, Vidar; Borchgrevink, Petter Chr.; Clausen, Thomas; Nesvåg, Ragnar; Skurtveit, Svetlana Ondrasova (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-14)
    BAKGRUNN<p> Vedvarende bruk av opioider kan ha uheldige konsekvenser. Vi har undersøkt vedvarende opioidbruk i pasientgruppersom fikk forskrevet opioider på ulike indikasjoner(langvarig smerte, palliativ behandling, andre (hvitresept)),samt gruppenessamtidige bruk av enkelte andre vanedannende legemidler.<p> MATERIALE OG METODE<p> <p>Personer med minst én utlevering av et opioid i Reseptregisteret ...

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