Recent additions

  • Metachronous Contralateral Testicular Cancer in the Cisplatin Era: A Population-Based Cohort Study 

    Hellesnes, Ragnhild; Myklebust, Tor Åge; Bremnes, Roy M.; Karlsdottir, Åsa; Kvammen, Øivind; Negaard, Helene Francisca Stigter; Tandstad, Torgrim; Wilsgaard, Tom; Fosså, Sophie Dorothea; Haugnes, Hege Sagstuen (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-23)
    PURPOSE - It is hypothesized that cisplatin-based chemotherapy (CBCT) reduces the occurrence of metachronous contralateral (second) germ cell testicular cancer (TC). However, studies including treatment details are lacking. The aim of this study was to assess the second TC risk, emphasizing the impact of previous TC treatment.<p> <p>PATIENTS AND METHODS - Based on the Cancer Registry of Norway, ...
  • Prognostic value of absolute quantification of mutated KRAS in circulating tumour DNA in lung adenocarcinoma patients prior to therapy 

    Wahl, Sissel Gyrid Freim; Hong, Yan Dai; Emdal, Elisabeth Fritzke; Ottestad, Anine Larsen; Dale, Vibeke Grotnes; Richardsen, Elin; Halvorsen, Tarje Onsøien; Grønberg, Bjørn Henning (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-27)
    Droplet digital polymerase chain reaction (ddPCR) is a highly sensitive and accurate method for quantification of nucleic acid sequences. We used absolute quantification of mutated v‐Ki‐ras2 Kirsten rat sarcoma viral oncogene homology gene (KRAS) by ddPCR to investigate the prognostic role of mutated KRAS in patients with KRAS‐mutated lung adenocarcinomas. Pre‐treatment plasma samples from 60 patients ...
  • Urinary excretion of epidermal growth factor and rapid loss of kidney function 

    Norvik, Jon Viljar; Harskamp, Laura R.; Nair, Viji; Shedden, Kerby; Solbu, Marit Dahl; Eriksen, Bjørn Odvar; Kretzler, Matthias; Gansevoort, Ron T.; Ju, Wenjun; Melsom, Toralf (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-17)
    Background - Lower urinary excretion of the kidney tubule–specific biomarker epidermal growth factor (uEGF) is associated with increased risk of renal function [glomerular filtration rate (GFR)] loss in diabetes and in patients with established chronic kidney disease (CKD). We investigated whether uEGF is associated with rapid GFR decline or incident CKD in the general population.<p> <p>Methods ...
  • Machine learning algorithms performed no better than regression models for prognostication in traumatic brain injury 

    Gravesteijn, BY; Nieboer, Daan; Ercole, Ari; Lingsma, Hester F; Nelson, David; Van Calster, Ben; Steyerberg, Ewout W; Andelic, Nada; Anke, Audny; Frisvold, Shirin; Helseth, Eirik; Røe, Cecilie; Røise, Olav; Skandsen, Toril; Vik, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-19)
    <i>Objective</i> - We aimed to explore the added value of common machine learning (ML) algorithms for prediction of outcome for moderate and severe traumatic brain injury.<br><br> <i>Study Design and Setting</i> - We performed logistic regression (LR), lasso regression, and ridge regression with key baseline predictors in the IMPACT-II database (15 studies, <i>n</i> = 11,022). ML algorithms ...
  • User requirements meet large-scale EHR suites: Norwegian preparations for Epic 

    Ellingsen, Gunnar; Hertzum, Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2020)
    Electronic health records (EHRs) are becoming the norm in healthcare. Typically, these EHRs are large-scale suite systems. The up-front presence of ready-for-use EHR suites changes the role of user requirements and the conditions for deciding which requirements to include in the final contract. In this paper, we investigate how user requirements are negotiated in the ongoing preparations for the ...
  • The effect of atmospheric pressure on oxygen saturation and dyspnea: the Tromsø study 

    Dohmen, Lisa M. E.; Spigt, Mark; Melbye, Hasse (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-03)
    A drop in atmospheric pressure, as observed at high altitudes, leads to decreased oxygen saturation. The effect of regular changes in barometric pressure at sea level has never been studied in a general population. A cohort of adults aged 40 years were examined with pulse oximetry at two separate visits, and the local barometric pressure was available from the local weather station. The study aimed ...
  • Fremtider 

    Risør, Torsten; Waltorp, Karen; Juul Jensen, Uffe (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-23)
    Der mangler ikke udfordringer for sundhed, sygdom og samfund i fremtiden. Ofte nævnes demografiske ændringer – en ældre befolkning og øget migration – som væsentlige grunde til forandring: flere med kroniske sygdomme og medfølgende risiko for flere indlæggelser og polyfarmaci; øget spredning af infektionssygdomme; forekomst af genetiske sygdomme i nye befolkningsgrupper. Direkte og indirekte ...
  • Stress and perceived health among primary care visitors in two corners of Europe: Scandinavia and Greece 

    Koppner, Jenny; Chatziarzenis, Marios; Faresjö, Tomas; Theodorsson, Elvar; Thorsell, Annika; Nilsson, Staffan; Olsen, Ole; Faresjö, Åshild Olsen (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-04)
    Background - The global financial crisis emerging in 2008 struck Greece especially hard, whereas Scandinavian countries were less affected. This has created a unique opportunity to study the long-term effect of community stress on populations. Increasing frequencies of mental health issues and poorer perceived health among the Greek population have been reported. The physiological marker of long-term ...
  • Repositioning of the global epicentre of non-optimal cholesterol 

    Taddei, Cristina; Zhou, Bin; Bixby, Honor; Carrillo-Larco, Rodrigo M.; Danaei, Goodarz; Jackson, Rod T.; Ahmed, Soheir H; Andersen, Lars Bo; Anderssen, Sigmund Alfred; Ariansen, Inger Kristine Holtermann; Bjertness, Espen; Bjertness, Marius Bergsmark; Graff-Iversen, Sidsel; Haugsgjerd, Teresa Risan; Janszky, Imre; Krokstad, Steinar; Laugsand, Lars Erik; Madar, Ahmed Ali; Mathiesen, Ellisiv B.; Meyer, Haakon E; Sen, Abhijit; Tell, Grete S.; Vatten, Lars Johan; Wilsgaard, Tom; Farzadfar, Farshad; Sophiea, Marisa K.; Di Cesare, Mariachiara; Iurilli, Maria L. C.; Martinez, Andrea Rodriguez; Asghari, Golaleh; Dhana, Klodian; Gulayin, Pablo; Kakarmath, Sujay; Santero, Marilina; Voortman, Trudy; Riley, Leanne M.; Cowan, Melanie J.; Savin, Stefan; Bennett, James E.; Stevens, Gretchen A.; Paciorek, Christopher J.; Aekplakorn, Wichai; Cifkova, Renata; Giampaoli, Simona; Kengne, Andre Pascal; Khang, Young-Ho; Kuulasmaa, Kari; Laxmaiah, Avula; Margozzini, Paula; Mathur, Prashant (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-03)
    High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which ...
  • Causes and Consequences of Gender Roles 

    Olsson, Maria (Doctoral thesis; Doktorgradsavhandling, 2021-05-03)
    This dissertation addresses the pervasive issue of women’s underrepresentation in agentic work and the equally important (but underexamined) issue of men’s underrepresentation in communal unpaid work. First, I review research and identify what conditions need to be met in order for counterstereotypical role models to break down some of the barriers to women’s entry into agentic work (Chapter 2). One ...
  • Prospects for improved glomerular filtration rate estimation based on creatinine-results from a transnational multicentre study 

    Bjõrk, Jonas; Nyman, Ulf; Courbebaisse, Marie; Couzi, Lionel; Dalton, R. Neil; Dubourg, Laurence; Ebert, Natalie; Eriksen, Bjõrn O.; Gaillard, Francois; Garrouste, Cyril; Grubb, Anders; Hansson, Magnus; Jacquemont1, Lola; Jones, Ian; Kamar, Nassim; Lamb, Edmund J.; Legendre, Christophe; Littmann, Karin; Mariat, Christophe; Melsom, Toralf; Rostaing, Lionel; Rule, Andrew D.; Schaeffner, Elke; Sundin, Per-Ola; Turner, Stephen; Åkesson, Anna; Delanaye, Pierre; Pottel, Hans (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-13)
    Background - The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation is routinely used to assess renal function but exhibits varying accuracy depending on patient characteristics and clinical presentation. The overall aim of the present study was to assess if and to what extent glomerular filtration rate (GFR) estimation based on creatinine can be improved.<p> <p>Methods ...
  • Combined effects of five prothrombotic genotypes and cancer on the risk of a first venous thromboembolic event 

    Skille, Hanne; Paulsen, Benedikte; Hveem, Kristian; Gabrielsen, Maiken Elvestad; Brumpton, Ben Michael; Hindberg, Kristian; Gran, Olga Vikhammer; Rosendaal, Frits Richard; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-16)
    Background - The role of combined prothrombotic genotypes in cancer‐related venous thromboembolism (VTE) is scarcely studied. We aimed to investigate the impact of a 5‐single nucleotide polymorphism (SNP) score on the risk of VTE in patients with and without cancer using a population‐based case‐cohort.<p> <p>Methods - Cases with a first VTE (n = 1493) and a subcohort (n = 13 072) were derived ...
  • Performance of Expanded Newborn Screening in Norway Supported by Post-Analytical Bioinformatics Tools and Rapid Second-Tier DNA Analyses 

    Tangeraas, Trine; Sæves, Ingjerd; Klingenberg, Claus; Jørgensen, Jens; Kristensen, Erle; Gunnarsdottir, Gunnþórunn; Hansen, Eirik Vangsøy; Strand, Janne Maren; Lundman, Emma; Ferdinandusse, Sacha; Salvador, Cathrin Lytomt; Woldseth, Berit; Bliksrud, Yngve Thomas; Sagredo, Carlos; Olsen, Øyvind Edon; Berge, Mona C.; Trømborg, Anette Kjoshagen; Ziegler, Anders; Zhang, Jin Hui; Sørgjerd, Linda Karlsen; Ytre-Arne, Mari Eknes; Hogner, Silje; Løvoll, Siv M.; Olavsen, Mette R. Kløvstad; Navarrete, Dionne; Gaup, Hege Junita; Lilje, Rina; Zetterström, Rolf H.; Stray-Pedersen, Asbjørg; Rootwelt-Revheim, Terje; Rinaldo, Piero; Rowe, Alexander D.; Pettersen, Rolf D. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-27)
    In 2012, the Norwegian newborn screening program (NBS) was expanded (eNBS) from screening for two diseases to that for 23 diseases (20 inborn errors of metabolism, IEMs) and again in 2018, to include a total of 25 conditions (21 IEMs). Between 1 March 2012 and 29 February 2020, 461,369 newborns were screened for 20 IEMs in addition to phenylketonuria (PKU). Excluding PKU, there were 75 true-positive ...
  • Association between anthropometry and lifestyle factors and risk of B-cell lymphoma: An exposome-wide analysis 

    Hosnijeh, Fatemeh Saberi; Casabonne, Delphine; Nieters, Alexandra; Solans, Marta; Naudin, Sabine; Ferrari, Pietro; McKay, James D.; Benavente, Yolanda; Weiderpass, Elisabete; Freisling, Heinz; Severi, Gianluca; Ruault, Marie-Christine Boutron; Bonet, Catalina; Besson, Caroline; Agnoli, Claudia; Barricarte, Aurelio; Christakoudi, Sofia; Masala, Giovanna; Knuppel, Anika; Sacerdote, Carlotta; Bueno-De-Mesquita, Bas; Tumino, Rosario; Huerta, José María; Schulze, Matthias B.; Kaaks, Rudolf; Amiano, Pilar; Barranco, Miguel Rodriguez; Canzian, Federico; Späth, Florentin; Jerkeman, Mats; Rylander, Charlotta; Tjønneland, Anne; Olsen, Anja; Borch, Kristin Benjaminsen; Vermeulen, Roel (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-31)
    To better understand the role of individual and lifestyle factors in human disease, an exposome‐wide association study was performed to investigate within a single‐study anthropometry measures and lifestyle factors previously associated with B‐cell lymphoma (BCL). Within the European Prospective Investigation into Cancer and nutrition study, 2402 incident BCL cases were diagnosed from 475 426 ...
  • Adapting and Going the Extra Mile: A Qualitative Study of Palliative Care in Rural Northern Norway From the Perspective of Healthcare Providers 

    Ervik, Bente; Brøndbo, Birgit; Johansen, May-Lill (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-24)
    Background - Despite significant developments in palliative care in recent decades, we still find important differences in access to and delivery of care in rural Norway.<p> <p>Objective - The aim of this study was to explore what healthcare professionals consider necessary to provide equality in care for palliative patients in rural areas.<p> <p>Methods - A qualitative approach with focus ...
  • How Academic Experiences and Educational Aspirations Relate to Well-Being and Health among Indigenous Sami Youth in Northern Norway. A Qualitative Approach 

    Nystad, Kristine; Ingstad, Benedicte; Spein, Anna Rita (Journal article; Tidsskriftartikkel; Peer reviewed, 2020)
    Increasingly, education occupies the lives of Indigenous adolescents worldwide. This qualitative study is part of the project “Circumpolar Indigenous Pathways to Adulthood” (CIPA), where the overall aim was to identify young people’s stressors in five circumpolar sites, and the resilience processes that safeguard transition into adulthood (Allen et al. 2014). The present study explores the everyday ...
  • Predictive and diagnostic utility of brief neuropsychological assessment in detecting Alzheimer's pathology and progression to dementia 

    Eliassen, Ingvild Vøllo; Fladby, Tormod; Kirsebom, Bjørn-Eivind; Waterloo, Knut; Eckerström, Marie; Wallin, Anders; Bråthen, Geir; Aarsland, Dag; Hessen, Erik (Journal article; Tidsskriftartikkel; Peer reviewed, 2020)
    Objective: To assess the role of brief neuropsychological assessments in prediction and identification of Alzheimer’s disease (AD) pathology and progression to AD dementia. Method: Adults (N = 255; range = 40–81 years) with self-reported cognitive decline underwent baseline and 2-year follow-up clinical assessment, including a brief neuropsychological screening and lumbar puncture. Five different ...
  • Sleep patterns and insomnia in a large population-based study of middle-aged and older adults: The Tromsø study 2015–2016 

    Sivertsen, Børge; Pallesen, Ståle; Friborg, Oddgeir; Nilsen, Kristian Bernhard; Bakke, Øystein; Goll, Jonas Bjørnskov; Hopstock, Laila Arnesdatter (Journal article; Tidsskriftartikkel, 2020-05-29)
    Epidemiological studies assessing adult sleep duration have yielded inconsistent findings and there are still large variations in estimation of insomnia prevalence according to the most recent diagnostic criteria. Our objective was to describe sleep patterns in a large population of middle‐aged and older adults, by employing accurate measures of both sleep duration and insomnia. Data stem from the ...
  • Physical activity and cold pain tolerance in the general population 

    Årnes, Anders; Nielsen, Christopher Sivert; Stubhaug, Audun; Fjeld, Mats Kirkeby; Hopstock, Laila Arnesdatter; Horsch, Alexander; Johansen, Aslak; Morseth, Bente; Wilsgaard, Tom; Steingrímsdóttir, Ólöf Anna (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-09)
    <p>Background - The relationship between habitual physical activity (PA) and experimental pain tolerance has been investigated in small samples of young, healthy and/or single‐sex volunteers. We used a large, population‐based sample to assess this relationship in men and women with and without chronic pain. <p>Methods - We used data from the sixth and seventh Tromsø Study surveys (2007–2008; ...
  • Feeling out of place: Internalized age stereotypes are associated with older employees’ sense of belonging and social motivation. 

    Rahn, Georg; Martiny, Sarah E.; Nikitin, Jana (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-05)
    Older employees are not only confronted with subtle negative stereotypes about cognitive decline, but they also tend to internalize these negative stereotypes (i.e., they agree with the idea that intellectual performance declines in old age and they feel affected by this decline). Previous research has shown that internalizing negative age stereotypes has detrimental effects on work-related outcomes. ...

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