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Stanozolol-N-glucuronide metabolites in human urine samples as suitable targets in terms of routine anti-doping analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-05)The exogenous anabolic-androgenic steroid (AAS) stanozolol stays one of the most detected substances in professional sports. Its detection is a fundamental part of doping analysis, and the analysis of this steroid has been intensively investigated for a long time. This contribution to the detection of stanozolol doping describes for the first time the unambiguous proof for the existence of ... -
Non-radiologist-performed abdominal point-of-care ultrasonography in paediatrics — a scoping review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-10)<i>Background</i> - Historically, US in the paediatric setting has mostly been the domain of radiologists. However, in the last decade, there has been an uptake of non-radiologist point-of-care US.<br><br> <i>Objective</i> - To gain an overview of abdominal non-radiologist point-of-care US in paediatrics.<br><br> <i>Materials and methods</i> - We conducted a scoping review regarding the uses ... -
A prognostic model for failure and worsening after lumbar microdiscectomy: a multicenter study from the Norwegian Registry for Spine Surgery
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-10)<i>Objective</i> - To develop a prognostic model for failure and worsening 1 year after surgery for lumbar disc herniation.<br><br> <i>Methods</i> - This multicenter cohort study included 11,081 patients operated with lumbar microdiscectomy, registered at the Norwegian Registry for Spine Surgery. Follow-up was 1 year. Uni- and multivariate logistic regression analyses were used to assess potential ... -
A combined effect of anti-HPA-1a and anti-HLA Class I in pregnancy?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-30)<i>Background</i> - Maternal anti–human leukocyte antigen (HLA) Class I is commonly detected alongside anti–human platelet antigen (HPA)-1a in fetal and neonatal alloimmune thrombocytopenia (FNAIT). Little is known regarding whether the presence of anti-HLA Class I may exert an additive effect on the risk and severity of FNAIT.<br><br> <i>Methods and Materials</i> - We reanalyzed samples originally ... -
Estimated Glomerular Filtration Rate (eGFR) based on cystatin C was associated with increased risk of hip and proximal humerus fractures in women and decreased risk of hip fracture in men, whereas eGFR based on creatinine was not associated with fracture risk in both sexes: The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-14)<i>Purpose</i> - Patients with end-stage kidney disease have an increased fracture risk. Whether mild to moderate reductions in kidney function is associated with increased fracture risk is uncertain. Results from previous studies may be confounded by muscle mass because of the use of creatinine-based estimates of the glomerular filtration rate (eGFRcre). We tested the hypothesis that lower eGFR ... -
The educational gradient in intake of energy, macro- and micronutrients in the Tromsø Study 2015-2016
(Master thesis; Mastergradsoppgave, 2020-05-27)<p>Background: Socioeconomic status is associated with inequalities in health. Unhealthy diet is a risk factor for non-communicable diseases, and socioeconomic inequalities exists also in diet. <p>Aim: To investigate the relationship between educational level and the intake of total energy, macro- and micronutrients. <p>Participants: 11,302 individuals (40-96 years) from Tromsø, Norway. <p>Methods: ... -
Child-focused practice in social services for adults in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-23)<i>Summary</i> - Children of social service users are at risk for developing mental health problems as well as social and behavioral problems. Social service counselors should therefore be aware of service users’ children and provide support for them. In fact, they are obligated by law to consider children's views and their best interests in cases affecting them. Despite this, little is known about ... -
Integrative, multi-omics, analysis of blood samples improves model predictions: applications to cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-05)<i>Background</i> - Cancer genomic studies often include data collected from several omics platforms. Each omics data source contributes to the understanding of the underlying biological process via source specific (“individual”) patterns of variability. At the same time, statistical associations and potential interactions among the different data sources can reveal signals from common biological ... -
Echocardiographic assessment of diastolic dysfunction in elderly patients with severe aortic stenosis before and after aortic valve replacement
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-28)Background - The 2016 guidelines of the American Society of Echocardiography (ASE) and European Association of Cardiovascular Imaging (EACVI) for evaluation of left ventricular (LV) diastolic dysfunction by Doppler flow and tissue Doppler- echocardiography do not adjust assessment of high filling pressures for patients with aortic stenosis (AS). However, most of the studies on this patient group ... -
Plasma levels of von Willebrand factor and future risk of incident venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-07)Several case-control studies have reported elevated plasma von Willebrand factor (VWF) levels in patients with venous thromboembolism (VTE) compared with controls. However, because few studies have investigated the association in a prospective design, it is unclear whether elevated plasma VWF is a risk factor or a consequence of the VTE event. Therefore, we aimed to investigate the prospective ... -
The Role of Plasma Extracellular Vesicles and Procoagulant Phospholipid Activity in Venous Thromboembolism
(Doctoral thesis; Doktorgradsavhandling, 2021-11-05)Venous thromboembolism (VTE) is the formation of a blood clot in, most commonly, the deep veins of the lower extremities and the pulmonary circulation. VTE is a prevalent disease associated with severe short- and long-term complications. Negatively charged procoagulant phospholipids (PPL), and phosphatidylserine (PS) in particular, are vital to efficient coagulation activation, and found expressed ... -
Expired carbon dioxide during newborn resuscitation as predictor of outcome
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-03)<i>Aim</i> - To explore and compare expired CO<sub>2</sub> (ECO<sub>2</sub>) and heart rate (HR), during newborn resuscitation with bag-mask ventilation, as predictors of 24-h outcome.<br><br> <i>Methods</i> - Observational study from March 2013 to June 2017 in a rural Tanzanian hospital. Side-stream measures of ECO<sub>2</sub>, ventilation parameters, HR, clinical information, and 24-h outcome ... -
Cardiovascular Effects of Epinephrine During Experimental Hypothermia (32°C) With Spontaneous Circulation in an Intact Porcine Model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-06)<i>Aims</i>: Rewarming from accidental hypothermia and therapeutic temperature management could be complicated by cardiac dysfunction. Although pharmacologic support is often applied when rewarming these patients, updated treatment recommendations are lacking. There is an underlying deficiency of clinical and experimental data to support such interventions and this prevents the development of clinical ... -
Associations with antibiotic prescribing for acute exacerbation of COPD in primary care: Secondary analysis of a randomised controlled trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-26)<i>Background</i> - C-reactive protein (CRP) point-of-care testing can reduce antibiotic use in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in primary care, without compromising patient care. Further safe reductions may be possible.<br><br> <i>Aim</i> - To investigate the associations between presenting features and antibiotic prescribing in patients with ... -
Molecular modeling study of the testosterone metabolizing enzyme UDP-glucuronosyltransferase 2B17
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-20)The dominant sex hormone testosterone is mainly metabolized by liver enzymes belonging to the uridine-diphospho (UDP) glucuronosyltransferase (UGT) family. These enzymes are the main phase II enzymes, and they have an important role in the detoxification of endogenous and exogenous compounds in humans. The aim of the present study was to improve the understanding of the binding properties of UGT2B17. ... -
Historical perspectives on using sham acupuncture in acupuncture clinical trials
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-02)<i>Background</i> - Trials of acupuncture in the West began before textbooks about acupuncture were generally available. This placed trials at risk of possible faulty assumptions about the practice of acupuncture and adoption of problematic research assumptions and methods. Further, this lack of information has had an influence on the theories of developing a valid and reliable sham control treatment ... -
Evaluating delivery of a CBT-based group intervention for schoolchildren with emotional problems: Examining the reliability and applicability of a video-based adherence and competence measure
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-28)Adherence and competence are essential parts of program fidelity and having adequate measures to assess these constructs is important. The Competence and Adherence Scale for Cognitive Behavioral Therapy (CAS CBT) was developed to evaluate the delivery of cognitive therapies for children with clinical anxiety. The present study is an assessment of the slightly adapted version of the CAS CBT evaluating ... -
Temporomandibular disorders in an adult population in northern Norway: A cross-sectional study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-16)<i>Objectives</i> - The aim of the study was to assess the prevalence of symptoms indicative of temporomandibular disorders (TMD) in an adult population in Troms County in Northern Norway, as well as the associations between TMD and socio-demographic factors, dental status, self-reported general, and oral health as well as oral health related quality of life (OHQoL).<br><br> <i>Methods</i> - Data ... -
Acceptability of collecting speech samples from the elderly via the telephone
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-17)<i>Objective</i> - There is a critical need to develop rapid, inexpensive and easily accessible screening tools for mild cognitive impairment (MCI) and Alzheimer’s disease (AD). We report on the efficacy of collecting speech via the telephone to subsequently develop sensitive metrics that may be used as potential biomarkers by leveraging natural language processing methods.<br><br> <i>Methods</i> ... -
Tumour cells express functional lymphatic endothelium-specific hyaluronan receptor in vitro and in vivo: Lymphatic mimicry promotes oral oncogenesis?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-05)Lymphatic metastasis represents the main route of tumour cell dissemination in oral squamous cell carcinoma (OSCC). Yet, there are no FDA-approved therapeutics targeting cancer-related lymphangiogenesis to date. The lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE-1), a specific lymphatic marker, is associated with poor survival in OSCC patients. In this study, we present a potential ...
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