Recent additions

  • Female genital self-image in women with and without female genital mutilation/cutting in Jeddah, Saudi Arabia 

    Rouzi, Abdulrahim A.; Berg, Rigmor; Alamoudi, Rana; Alzaban, Faten; Sehlo, Mohammad (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-29)
    Introduction - The consequences of female genital mutilation/cutting (FGM/C) on female genital self-image are not known.<p> <p>Aim - To assess whether women with and without FGM/C differed with regard to female genital self-image.<p> <p>Methods - A survey was administered to a group of women attending the King Abdulaziz University Hospital obstetrics and gynecology clinic from December 2016 ...
  • Combined Influence of Waist and Hip Circumference on Risk of Death in a Large Cohort of European and Australian Adults 

    Cameron, Adrian J.; Romaniuk, Helena; Orellana, Liliana; Dallongeville, Jean; Dobson, Annette J; Drygas, Wojciech; Ferrario, Marco; Ferrieres, Jean; Giampaoli, Simona; Gianfagna, Francesco; Iacoviello, Licia; Jousilahti, Pekka; Kee, Frank; Moitry, Marie; Niiranen, Teemu J; Pajak, Andrzej; Palmieri, Luigi; Palosaari, Tarja; Mannisto, Satu; Tamosiunas, Abdonas; Thorand, Barbara; Toft, Ulla; Vanuzzo, Diego; Salomaa, Veikko; Veronesi, Giovanni; Wilsgaard, Tom; Kuulasmaa, Kari; Söderberg, Stefan (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-30)
    Background - Waist circumference and hip circumference are both strongly associated with risk of death; however, their joint association has rarely been investigated.<p> <p>Methods and Results - The MONICA Risk, Genetics, Archiving, and Monograph (MORGAM) Project was conducted in 30 cohorts from 11 countries; 90 487 men and women, aged 30 to 74 years, predominantly white, with no history of ...
  • A possible effect of montelukast on neurological aging examined by the use of register data 

    Grinde, Bjørn; Schirmer, Henrik; Eggen, Anne Elise; Aigner, Ludwig; Engdahl, Bo Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-09)
    Background - The leukotriene receptor antagonist montelukast has been shown to rejuvenate aged brains in rats; however, data on humans are still scarce. Objective To investigate if montelukast may alleviate degenerative neurological changes using a register data. Setting Norwegian registry data analyses. <p> <p>Method - The present observational study was based on data from the Norwegian Prescription ...
  • Barn og unges medvirkning i barnevernet: en systematisk kartleggingsoversikt 

    Ormstad, Sari Susanna; Hestevik, Christine Hillestad; Munthe-Kaas, Heather Menzies; Blaasvær, Nora; Muller, Ashley Elizabeth; Berg, Rigmor (Research report; Forskningsrapport, 2020)
    Barn har rett til å medvirke i alle saker som vedrører dem. Barne-, ungdoms- og familiedirektoratet (Bufdir) ønsket en oversikt over forskning som har undersøkt barn og unges medvirkning i barnevernet: 1) hvordan barn og unge involveres i barnevernet, 2) barn og unges opplevelser med og preferanser for medvirkning, 3) dilemmaer knyttet til medvirkning, og 4) effektene av medvirkning.<p> <p>Metode ...
  • Serologic markers of Chlamydia trachomatis and other sexually transmitted infections and subsequent ovarian cancer risk: Results from the EPIC cohort 

    Idahl, Annika; Le Cornet, Charlotte; González Maldonado, Sandra; Waterboer, Tim; Bender, Noemi; Tjønneland, Anne; Hansen, Louise; Boutron-Ruault, Marie-Christine; Fournier, Agnès; Kvaskoff, Marina; Boeing, Heiner; Trichopoulou, Antonia; Valanou, Elissavet; Peppa, Eleni; Palli, Domenico; Agnoli, Claudia; Mattiello, Amalia; Tumino, Rosaria; Sacerdote, Carlotta; Onland-Moret, N. Charlotte; Gram, Inger Torhild; Weiderpass, Elisabete; Quirós, J. Ramón; Duell, Eric J.; Sánchez, Maria-Jose; Chirlaque, Maria-Dolores; Barricarte, Aurelio; Gil, Leire; Brändstedt, Jenny; Riesbeck, Kristian; Lundin, Eva; Khaw, Kay-Tee; Perez-Cornago, Aurora; Gunter, Marc; Dossus, Laure; Kaaks, Rudolf; Fortner, Renée T. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-03)
    A substantial proportion of epithelial ovarian cancer (EOC) arises in the fallopian tube and other epithelia of the upper genital tract; these epithelia may incur damage and neoplastic transformation after sexually transmitted infections (STI) and pelvic inflammatory disease. We investigated the hypothesis that past STI infection, particularly Chlamydia trachomatis, is associated with higher EOC ...
  • Smoking-Related Risks of Colorectal Cancer by Anatomical Subsite and Sex 

    Gram, Inger Torhild; Park, Song-Yi; Wilkens, Lynne R; Haiman, Christopher A.; Le Marchand, Loïc (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-23)
    The purpose of this study was to examine whether the increased risk of colorectal cancer due to cigarette smoking differed by anatomical subsite or sex. We analyzed data from 188,052 participants aged 45–75 years (45% men) who were enrolled in the Multiethnic Cohort Study in 1993–1996. During a mean follow-up period of 16.7 years, we identified 4,879 incident cases of invasive colorectal adenocarcinoma. ...
  • C-reactive protein-guided antibiotic prescribing for COPD exacerbations: A qualitative evaluation 

    Phillips, Rhiannon; Stanton, H.; Singh-Mehta, A.; Gillespie, David; Bates, Janine; Gal, Micaela; Thomas-Jones, Emma; Lowe, Rachel; Hood, Kerenza; Llor, Carl; Melbye, Hasse; Cals, Jochen; White, Patrick; Butler, Christopher C.; Francis, Nick (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-25)
    Background - Antibiotics are prescribed to >70% of patients presenting in primary care with an acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The PACE randomised controlled trial found that a C-reactive protein point-of-care test (CRP-POCT) management strategy for AECOPD in primary care resulted in a 20% reduction in patient-reported antibiotic consumption over 4 weeks.<p> <p>Aim ...
  • Metachronous Contralateral Testicular Cancer in the Cisplatin Era: A Population-Based Cohort Study 

    Hellesnes, Ragnhild; Myklebust, Tor Åge; Bremnes, Roy M.; Karlsdottir, Åsa; Kvammen, Øivind; Negaard, Helene Francisca Stigter; Tandstad, Torgrim; Wilsgaard, Tom; Fosså, Sophie Dorothea; Haugnes, Hege Sagstuen (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-23)
    PURPOSE - It is hypothesized that cisplatin-based chemotherapy (CBCT) reduces the occurrence of metachronous contralateral (second) germ cell testicular cancer (TC). However, studies including treatment details are lacking. The aim of this study was to assess the second TC risk, emphasizing the impact of previous TC treatment.<p> <p>PATIENTS AND METHODS - Based on the Cancer Registry of Norway, ...
  • Prognostic value of absolute quantification of mutated KRAS in circulating tumour DNA in lung adenocarcinoma patients prior to therapy 

    Wahl, Sissel Gyrid Freim; Hong, Yan Dai; Emdal, Elisabeth Fritzke; Ottestad, Anine Larsen; Dale, Vibeke Grotnes; Richardsen, Elin; Halvorsen, Tarje Onsøien; Grønberg, Bjørn Henning (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-27)
    Droplet digital polymerase chain reaction (ddPCR) is a highly sensitive and accurate method for quantification of nucleic acid sequences. We used absolute quantification of mutated v‐Ki‐ras2 Kirsten rat sarcoma viral oncogene homology gene (KRAS) by ddPCR to investigate the prognostic role of mutated KRAS in patients with KRAS‐mutated lung adenocarcinomas. Pre‐treatment plasma samples from 60 patients ...
  • Urinary excretion of epidermal growth factor and rapid loss of kidney function 

    Norvik, Jon Viljar; Harskamp, Laura R.; Nair, Viji; Shedden, Kerby; Solbu, Marit Dahl; Eriksen, Bjørn Odvar; Kretzler, Matthias; Gansevoort, Ron T.; Ju, Wenjun; Melsom, Toralf (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-17)
    Background - Lower urinary excretion of the kidney tubule–specific biomarker epidermal growth factor (uEGF) is associated with increased risk of renal function [glomerular filtration rate (GFR)] loss in diabetes and in patients with established chronic kidney disease (CKD). We investigated whether uEGF is associated with rapid GFR decline or incident CKD in the general population.<p> <p>Methods ...
  • Machine learning algorithms performed no better than regression models for prognostication in traumatic brain injury 

    Gravesteijn, BY; Nieboer, Daan; Ercole, Ari; Lingsma, Hester F; Nelson, David; Van Calster, Ben; Steyerberg, Ewout W; Andelic, Nada; Anke, Audny; Frisvold, Shirin; Helseth, Eirik; Røe, Cecilie; Røise, Olav; Skandsen, Toril; Vik, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-19)
    <i>Objective</i> - We aimed to explore the added value of common machine learning (ML) algorithms for prediction of outcome for moderate and severe traumatic brain injury.<br><br> <i>Study Design and Setting</i> - We performed logistic regression (LR), lasso regression, and ridge regression with key baseline predictors in the IMPACT-II database (15 studies, <i>n</i> = 11,022). ML algorithms ...
  • User requirements meet large-scale EHR suites: Norwegian preparations for Epic 

    Ellingsen, Gunnar; Hertzum, Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2020)
    Electronic health records (EHRs) are becoming the norm in healthcare. Typically, these EHRs are large-scale suite systems. The up-front presence of ready-for-use EHR suites changes the role of user requirements and the conditions for deciding which requirements to include in the final contract. In this paper, we investigate how user requirements are negotiated in the ongoing preparations for the ...
  • The effect of atmospheric pressure on oxygen saturation and dyspnea: the Tromsø study 

    Dohmen, Lisa M. E.; Spigt, Mark; Melbye, Hasse (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-03)
    A drop in atmospheric pressure, as observed at high altitudes, leads to decreased oxygen saturation. The effect of regular changes in barometric pressure at sea level has never been studied in a general population. A cohort of adults aged 40 years were examined with pulse oximetry at two separate visits, and the local barometric pressure was available from the local weather station. The study aimed ...
  • Fremtider 

    Risør, Torsten; Waltorp, Karen; Juul Jensen, Uffe (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-23)
    Der mangler ikke udfordringer for sundhed, sygdom og samfund i fremtiden. Ofte nævnes demografiske ændringer – en ældre befolkning og øget migration – som væsentlige grunde til forandring: flere med kroniske sygdomme og medfølgende risiko for flere indlæggelser og polyfarmaci; øget spredning af infektionssygdomme; forekomst af genetiske sygdomme i nye befolkningsgrupper. Direkte og indirekte ...
  • Stress and perceived health among primary care visitors in two corners of Europe: Scandinavia and Greece 

    Koppner, Jenny; Chatziarzenis, Marios; Faresjö, Tomas; Theodorsson, Elvar; Thorsell, Annika; Nilsson, Staffan; Olsen, Ole; Faresjö, Åshild Olsen (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-04)
    Background - The global financial crisis emerging in 2008 struck Greece especially hard, whereas Scandinavian countries were less affected. This has created a unique opportunity to study the long-term effect of community stress on populations. Increasing frequencies of mental health issues and poorer perceived health among the Greek population have been reported. The physiological marker of long-term ...
  • Repositioning of the global epicentre of non-optimal cholesterol 

    Taddei, Cristina; Zhou, Bin; Bixby, Honor; Carrillo-Larco, Rodrigo M.; Danaei, Goodarz; Jackson, Rod T.; Ahmed, Soheir H; Andersen, Lars Bo; Anderssen, Sigmund Alfred; Ariansen, Inger Kristine Holtermann; Bjertness, Espen; Bjertness, Marius Bergsmark; Graff-Iversen, Sidsel; Haugsgjerd, Teresa Risan; Janszky, Imre; Krokstad, Steinar; Laugsand, Lars Erik; Madar, Ahmed Ali; Mathiesen, Ellisiv B.; Meyer, Haakon E; Sen, Abhijit; Tell, Grete S.; Vatten, Lars Johan; Wilsgaard, Tom; Farzadfar, Farshad; Sophiea, Marisa K.; Di Cesare, Mariachiara; Iurilli, Maria L. C.; Martinez, Andrea Rodriguez; Asghari, Golaleh; Dhana, Klodian; Gulayin, Pablo; Kakarmath, Sujay; Santero, Marilina; Voortman, Trudy; Riley, Leanne M.; Cowan, Melanie J.; Savin, Stefan; Bennett, James E.; Stevens, Gretchen A.; Paciorek, Christopher J.; Aekplakorn, Wichai; Cifkova, Renata; Giampaoli, Simona; Kengne, Andre Pascal; Khang, Young-Ho; Kuulasmaa, Kari; Laxmaiah, Avula; Margozzini, Paula; Mathur, Prashant (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-03)
    High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which ...
  • Causes and Consequences of Gender Roles 

    Olsson, Maria (Doctoral thesis; Doktorgradsavhandling, 2021-05-03)
    This dissertation addresses the pervasive issue of women’s underrepresentation in agentic work and the equally important (but underexamined) issue of men’s underrepresentation in communal unpaid work. First, I review research and identify what conditions need to be met in order for counterstereotypical role models to break down some of the barriers to women’s entry into agentic work (Chapter 2). One ...
  • Prospects for improved glomerular filtration rate estimation based on creatinine-results from a transnational multicentre study 

    Bjõrk, Jonas; Nyman, Ulf; Courbebaisse, Marie; Couzi, Lionel; Dalton, R. Neil; Dubourg, Laurence; Ebert, Natalie; Eriksen, Bjõrn O.; Gaillard, Francois; Garrouste, Cyril; Grubb, Anders; Hansson, Magnus; Jacquemont1, Lola; Jones, Ian; Kamar, Nassim; Lamb, Edmund J.; Legendre, Christophe; Littmann, Karin; Mariat, Christophe; Melsom, Toralf; Rostaing, Lionel; Rule, Andrew D.; Schaeffner, Elke; Sundin, Per-Ola; Turner, Stephen; Åkesson, Anna; Delanaye, Pierre; Pottel, Hans (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-13)
    Background - The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation is routinely used to assess renal function but exhibits varying accuracy depending on patient characteristics and clinical presentation. The overall aim of the present study was to assess if and to what extent glomerular filtration rate (GFR) estimation based on creatinine can be improved.<p> <p>Methods ...
  • Combined effects of five prothrombotic genotypes and cancer on the risk of a first venous thromboembolic event 

    Skille, Hanne; Paulsen, Benedikte; Hveem, Kristian; Gabrielsen, Maiken Elvestad; Brumpton, Ben Michael; Hindberg, Kristian; Gran, Olga Vikhammer; Rosendaal, Frits Richard; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-16)
    Background - The role of combined prothrombotic genotypes in cancer‐related venous thromboembolism (VTE) is scarcely studied. We aimed to investigate the impact of a 5‐single nucleotide polymorphism (SNP) score on the risk of VTE in patients with and without cancer using a population‐based case‐cohort.<p> <p>Methods - Cases with a first VTE (n = 1493) and a subcohort (n = 13 072) were derived ...
  • Performance of Expanded Newborn Screening in Norway Supported by Post-Analytical Bioinformatics Tools and Rapid Second-Tier DNA Analyses 

    Tangeraas, Trine; Sæves, Ingjerd; Klingenberg, Claus; Jørgensen, Jens; Kristensen, Erle; Gunnarsdottir, Gunnþórunn; Hansen, Eirik Vangsøy; Strand, Janne Maren; Lundman, Emma; Ferdinandusse, Sacha; Salvador, Cathrin Lytomt; Woldseth, Berit; Bliksrud, Yngve Thomas; Sagredo, Carlos; Olsen, Øyvind Edon; Berge, Mona C.; Trømborg, Anette Kjoshagen; Ziegler, Anders; Zhang, Jin Hui; Sørgjerd, Linda Karlsen; Ytre-Arne, Mari Eknes; Hogner, Silje; Løvoll, Siv M.; Olavsen, Mette R. Kløvstad; Navarrete, Dionne; Gaup, Hege Junita; Lilje, Rina; Zetterström, Rolf H.; Stray-Pedersen, Asbjørg; Rootwelt-Revheim, Terje; Rinaldo, Piero; Rowe, Alexander D.; Pettersen, Rolf D. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-27)
    In 2012, the Norwegian newborn screening program (NBS) was expanded (eNBS) from screening for two diseases to that for 23 diseases (20 inborn errors of metabolism, IEMs) and again in 2018, to include a total of 25 conditions (21 IEMs). Between 1 March 2012 and 29 February 2020, 461,369 newborns were screened for 20 IEMs in addition to phenylketonuria (PKU). Excluding PKU, there were 75 true-positive ...

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