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Can a mock medication-taking learning activity enable pharmacy students to experience the range of barriers and facilitators to medication adherence? An analysis informed by the Theoretical Domains Framework and COM-B model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-08)Background: Pharmacy professionals are well-placed to provide medication adherence support to patients. The Capability, Opportunity, Motivation-Behaviour (COM–B) and Theoretical Domains Framework (TDF) are two complementary models previously applied to medication-taking behaviour. Understanding the patient-specific barriers and facilitators to adherence using psychological frameworks from the ... -
Experiences of people living with HIV in low- and middle-income countries and their perspectives in self-management: a meta-synthesis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-31)Introduction Availability of anti-retroviral treatment has changed HIV in to a manageable chronic disease, making efective self-management essential. However, only a few studies in low- and middle-income countries (LMICs) reported experiences of people living with HIV (PLWH) on self-management.<p> <p>Methods This meta-synthesis of qualitative studies investigated perspectives of PLWH in LMICs on ... -
Whole genome sequencing of recombinant viruses obtained from co-infection and superinfection of Vero cells with modified vaccinia virus ankara vectored influenza vaccine and a naturally occurring cowpox virus
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-03)Modified vaccinia virus Ankara (MVA) has been widely tested in clinical trials as recombinant vector vaccine against infectious diseases and cancers in humans and animals. However, one biosafety concern about the use of MVA vectored vaccine is the potential for MVA to recombine with naturally occurring orthopoxviruses in cells and hosts in which it multiplies poorly and, therefore, producing ... -
Diagnostic flow for all patients referred with non-specific symptoms of cancer to a diagnostic centre in Denmark: A descriptive study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-05)Background: Since 2012, Cancer Patient Pathways for Non-specific Symptoms and Signs of Cancer (NSSC-CPP) have been implemented in Scandinavia and UK.<p> <p>Objectives: This study aimed to describe the diagnostic flow for all patients referred from 1 January to 30 June 2020 to the NSSC-CPP in the Diagnostic Centre in Farsø (DC-F), Denmark. Methods: During the study period, we prospectively recorded ... -
Machine Learning Models for Predicting Disability and Pain Following Lumbar Disc Herniation Surgery
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-07)IMPORTANCE Lumber disc herniation surgery can reduce pain and disability. However, a sizable minority of individuals experience minimal benefit, necessitating the development of accurate prediction models.<p> <p>OBJECTIVE To develop and validate prediction models for disability and pain 12 months after lumbar disc herniation surgery. <p>DESIGN, SETTING, AND PARTICIPANTS A prospective, multicenter, ... -
Thrombolytic Treatment in Wake-Up Stroke: A Propensity Score-Matched Analysis of Treatment Effectiveness in the Norwegian Stroke Registry
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-31)BACKGROUND: Previous clinical trials found improved outcome of thrombolytic treatment in patients with ischemic wake-up stroke (WUS) selected by advanced imaging techniques. The authors assessed the effectiveness of thrombolytic treatment in patients with WUS in a nationwide stroke registry.<p> <p>METHODS AND RESULTS: Using propensity score matching, the authors assessed the effectiveness and ... -
‘There’s a will, but not a way’: Norwegian GPs’ experiences of collaboration with child welfare services – a grounded theory study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-24)Background Adverse childhood experiences can have immediate effects on a child’s wellbeing and health and may also result in disorders and illness in adult life. General practitioners are in a good position to identify and support vulnerable children and parents and to collaborate with other agencies such as child welfare services. There is a need for better integration of relevant services. ... -
Gentamicin bør fortsatt inngå i empirisk sepsisregime hos voksne
(Journal article; Tidsskriftartikkel, 2024-02-26)Kombinasjonen av et smalspektret betalaktamantibiotikum og aminoglykosid bør fortsatt være førstevalg i norske retningslinjer som empirisk antibiotikabehandling av de fleste alvorlige infeksjoner. -
Body mass index is associated with health-related quality of life and disease characteristics in young adults with juvenile idiopathic arthritis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-02)Background There is a growing interest concerning the relationship between obesity and several medical conditions and inflammation. Nevertheless, there is a lack of studies regarding body mass index (BMI) among patients with juvenile idiopathic arthritis (JIA). Our aim was to investigate the impact of BMI on health-related quality of life (HRQoL) measured with a 36-Item Short Form Survey (SF-36), ... -
Modulation of multidrug-resistant clone success in Escherichia coli populations: a longitudinal, multi-country, genomic and antibiotic usage cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-11)Background The effect of antibiotic usage on the success of multidrug-resistant (MDR) clones in a population remains unclear. With this genomics-based molecular epidemiology study, we aimed to investigate the contribution of antibiotic use to Escherichia coli clone success, relative to intra-strain competition for colonisation and infection.<p> <p>Methods We sequenced all the available E coli ... -
The relationship between physical performance and alcohol consumption levels in Russian adults
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-16)Investigating the relationship between alcohol consumption and physical performance, we used data from the 2015–2018 Know Your Heart study on 4215 adults aged 35–69 from Arkhangelsk and Novosibirsk, Russia. We classified participants’ drinking status into non-drinking, non-problem drinking, hazardous drinking, and harmful drinking based on their self-reported drinking behaviors. To evaluate ... -
Inadequate nutritional care for malnourished patients in four university hospitals – The QuaNuT study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-30)Background & Aims: Adequate nutritional care to malnourished patients is described as a human right, and recommendations from nutritional care guidelines are legally binding in Norway. The primary objective of this study was to investigate nutritional care in malnourished hospitalized patients. We also wanted to describe the association between malnutrition and length of stay (LOS), readmission, ... -
Exploring public health nurses' acceptability of clinical assessment tools in a Norwegian child health centre
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-12)Background: Infants’ symptoms of mental struggle are often diffuse and undifferentiated, and health services do not identify many infants at risk of poor development. However, primary health care is advantageous for early identification, given there are frequent consultations during the infant’s first two years. Health policy encourages using evidence-based screening but use varies in primary ... -
Generative artificial intelligence to produce high-fidelity blastocyst-stage embryo images
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-10)STUDY QUESTION - Can generative artificial intelligence (AI) models produce high-fidelity images of human blastocysts?<p> <p>SUMMARY ANSWER - Generative AI models exhibit the capability to generate high-fidelity human blastocyst images, thereby providing substantial training datasets crucial for the development of robust AI models.<p> <p>WHAT IS KNOWN ALREADY - The integration of AI into IVF ... -
Randomized controlled trial of nasogastric tube use after esophagectomy: Study protocol for the kinetic trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-16)Esophagectomy is a complex and complication laden procedure. Despite centralization, variations in perioparative strategies reflect a paucity of evidence regarding optimal routines. The use of nasogastric (NG) tubes post esophagectomy is typically associated with significant discomfort for the patients. We hypothesize that immediate postoperative removal of the NG tube is non-inferior to current ... -
Data Resource Profile: The HUNT Biobank
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-04)<uli> <li>The Trøndelag Health Study (HUNT) Biobank, located at Levanger, Mid-Norway, holds biological material from 110 000 participants (aged 13–100 years) from the longitudinal population-based HUNT Study, Norway, including whole blood, serum, plasma, DNA, RNA, urine, saliva and fecal samples, optimally handled and stored for research purposes.</li> <li>Among 94 000 participants with ... -
Novel loss-of-function variants expand ABCC9-related intellectual disability and myopathy syndrome
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-13)Loss-of-function mutation of ABCC9, the gene encoding the SUR2 subunit of ATP sensitive-potassium (KATP) channels, was recently associated with autosomal recessive ABCC9-related intellectual disability and myopathy syndrome (AIMS). Here we identify nine additional subjects, from seven unrelated families, harbouring different homozygous loss-of-function variants in ABCC9 and presenting with a conserved ... -
Attitudes towards wife-beating justification and its association with female genital mutilation - analysis of ever-married Somali women in the 2020 Somali Health and Demographic Survey
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-17)Background - In Somalia, despite its prohibition, female circumcision persists alongside significant intimate partner violence. This study examines the prevalence of wife-beating justification among Somali women and its link to the perception that female genital mutilation/cutting (FGM/C) is a religious obligation.<p> <p>Methods - We studied 7726 married Somali women 15–49 y of age from the 2020 ... -
Needs for community-based rehabilitation services and support 12 months after moderate and severe physical traumatic injuries: a brief report
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08)Patients with physical traumatic injuries frequently require long-term rehabilitation services. To strengthen rehabilitation services in the postacute phase, we need to assess characteristics of this population and their healthcare and rehabilitation needs in the community. This brief report summarizes the frequency of unmet rehabilitation needs in community-based rehabilitation during the first ... -
A histological study of the protracted dismantling of the spent (Sertoli-only) shark spermatocyst post-spermiation: Insight from species with or without testis-associated lymphomyeloid tissue
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-27)Sertoli cells of sharks are non-permanent components of the spermatocyst that they share exclusively with only one germ cell stage. After spermiation, all Sertoli cells, and thus the whole spent cyst, are disposed of in an area adjacent to the spermatozoal spermatocysts, that is, the resorption zone (RZ). Differences in the histology and magnitude of the RZ of the mature blue shark and Greenland ...
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