Recent additions

  • Vaccine Induced Immune Thrombotic Thrombocytopenia Causing a Severe Form of Cerebral Venous Thrombosis With High Fatality Rate: A Case Series 

    Wiedmann, Markus; Skattør, Thor Håkon; Stray-Pedersen, Arne; Romundstad, Luis Georg; Antal, Ellen-Ann; Marthinsen, Pål Bache; Sørvoll, Ingvild Hausberg; Ernstsen, Siw Leiknes; Lund, Christian G.; Holme, Pål Andre; Johansen, Tonje Okkenhaug; Brunborg, Cathrine; Aamodt, Anne Hege; Schultz, Nina Haagenrud; Skagen, Karolina Ryeng; Skjelland, Mona Elisabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-30)
    During a 2-week period, we have encountered five cases presenting with the combination of cerebral venous thrombosis (CVT), intracerebral hemorrhage and thrombocytopenia. A clinical hallmark was the rapid and severe progression of disease in spite of maximum treatment efforts, resulting in fatal outcome in for 4 out of 5 patients. All cases had received ChAdOx1 nCov-19 vaccine 1–2 weeks earlier and ...
  • A rapid, sensitive, and specific assay to measure TF activity based on chromogenic determination of thrombin generation 

    Østerud, Bjarne; Latysheva, Nadezhda; Schoergenhofer, Christian; Jilma, Bernd; Hansen, John-Bjarne; Snir, Omri (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-25)
    Background - Most tissue factor (TF) activity assays are based on measurement of factor X (FX) activation by TF in the presence of factor VII (FVII)/FVIIa. This requires long incubation, which may result in TF-independent activity of FX and inaccurate measurement of TF activity.<p> <p>Aim - To develop a sensitive and specific TF activity assay, which does not register a non-specific TF activity, ...
  • Rosuvastatin treatment decreases plasma procoagulant phospholipid activity after a VTE: A randomized controlled trial 

    Ramberg, Cathrine; Hindberg, Kristian; Biedermann, Joseph S.; Cannegieter, Suzanne C.; van der Meer, Felix J.; Snir, Omri; Leebeek, Frank W. G.; Kruip, Marieke J. H. A.; Hansen, John Bjarne; Lijfering, Willem M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-25)
    Background - Venous thromboembolism (VTE) is a frequent cardiovascular disease with severe complications, including recurrence and death. There is a great need for alternative prophylactic treatment options as anticoagulation is accompanied by increased bleeding risk. Statins are reported to reduce the risk of incident and recurrent VTE, but the mechanisms are elusive. Procoagulant phospholipids ...
  • Drug-eluting or bare-metal stents for left anterior descending or left main coronary artery revascularization 

    Piccolo, Raffaele; Bonaa, Kaare H.; Efthimiou, Orestis; Varenne, Olivier; Urban, Philip; Kaiser, Christoph; Räber, Lorenz; de Belder, Adam; Remkes, Wouter; Van’T Hof, Arnoud W. J.; Stankovic, Goran; Lemos, Pedro A.; Wilsgaard, Tom; Reifart, Jörg; Rodriguez, Alfredo E.; Ribeiro, Expedito E.; Serruys, Patrick W. J. C.; Abizaid, Alex; Sabaté, Manel; Byrne, Robert A.; de la Torre Hernandez, Jose M.; Wijns, William; Esposito, Giovanni; Jüni, Peter; Windecker, Stephan; Valgimigli, Marco (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-08)
    Background - New‐generation drug‐eluting stents (DES) reduce target‐vessel revascularization compared with bare‐metal stents (BMS), and recent data suggest that DES have the potential to decrease the risk of myocardial infarction and cardiovascular mortality. We evaluated the treatment effect of DES versus BMS according to the target artery (left anterior descending [LAD] and/or left main [LM] versus ...
  • Obesity does not protect from subarachnoid haemorrhage: Pooled analysis of 3 large prospective Nordic cohorts 

    Rautalin, Ilari; Kaprio, Jaakko; Ingebrigtsen, Tor; Jousilahti, Pekka; Løchen, Maja-Lisa; Romundstad, Pål Richard; Salomaa, Veikko; Vik, Anne; Wilsgaard, Tom; Mathiesen, Ellisiv B.; Sandvei, Marie Søfteland; Korja, Miikka (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-10)
    Background and purpose: Several population-based cohort studies have related higher body mass index (BMI) to a decreased risk of subarachnoid hemorrhage (SAH). The main objective of our study was to investigate whether the previously reported inverse association can be explained by modifying effects of the most important risk factors of SAH—smoking and hypertension.<p> <p>Methods: We conducted ...
  • Biofilm Responsive Zwitterionic Antimicrobial Nanoparticles to Treat Cutaneous Infection 

    Obuobi, Sybil Akua Okyerewa; Phung, Anna Ngoc; Julin, Kjersti; Johannessen, Mona; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-16)
    To avert the poor bioavailability of antibiotics during S. aureus biofilm infections, a series of zwitterionic nanoparticles containing nucleic acid nanostructures were fabricated for the delivery of vancomycin. The nanoparticles were prepared with three main lipids: (i) neutral (soy phosphatidylcholine; P), (ii) positively charged ionizable (1,2-dioleyloxy-3-dimethylaminopropane; D), and (iii) ...
  • Social and life skills in adolescents who have self-harmed: analysis of survey responses from a national sample of adolescents in Norway 

    Fadum, Elin Anita; Carlsen, Ellen Øen; Ramberg, Maria; Strand, Leif Aage; Håberg, Siri Eldevik; Borud, Einar Kristian; Martinussen, Monica (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-12)
    Objective - Social and life skills (SLS) may be important in the prevention and treatment of self-harm, but few studies have described this relationship. We examined three components of SLS in adolescents who reported self-harm that was, according to themselves, diagnosed by a clinician.<p> <p>Design - Cross-sectional.<p> <p>Setting - National screening prior to military service.<p> <p>Participants ...
  • The Infectious Dose Shapes Vibrio Cholerae Within-Host Dynamics 

    Gillman, Aaron Nicholas; Mahmutovic, Anel; Abel zur Wiesch, Pia; Abel, Sören (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-07)
    During infection, the rates of pathogen replication, death, and migration affect disease progression, dissemination, transmission, and resistance evolution. Here, we follow the population dynamics of Vibrio cholerae in a mouse model by labeling individual bacteria with one of >500 unique, fitness-neutral genomic tags. Using the changes in tag frequencies and CFU numbers, we inform a mathematical ...
  • Effect of cements on fracture resistance of monolithic zirconia crowns 

    Nakamura, Keisuke; Mouhat, Mathieu; Nergård, John Magnus; Lægreid, Solveig Jenssen; Kanno, Taro; Milleding, Percy; Ørtengren, Ulf Thore (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-01-26)
    Objectives - The present study investigated the effect of cements on fracture resistance of monolithic zirconia crowns in relation to their compressive strength.<p> <p>Materials and methods - Four different cements were tested: zinc phosphate cement (ZPC), glass-ionomer cement (GIC), self-adhesive resin-based cement (SRC) and resin-based cement (RC). RC was used in both dual cure mode (RC-D) and ...
  • Sex-specific height-correction of weight in a population with ethnic groups that differ in stature - the SAMINOR 1 Survey: a cross-sectional study 

    Michalsen, Vilde Lehne; Coucheron, David Andre; Kvaløy, Kirsti; Melhus, Marita (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-07)
    Background: Body mass index (BMI, weight/height2) is a common proxy for body fatness, but it is negatively correlated with height. In Norway, the ethnic Sami people have had higher BMI and lower height than their non-Sami peers. This article aimed to examine if previous findings of higher obesity measures in Sami compared to non-Sami persist when applying an adequately height-corrected weight ...
  • Psychometric properties of the Brief Problem Monitor (BPM) in children with internalizing symptoms: examining baseline data from a national randomized controlled intervention study 

    Pedersen, Marit Løtveit; Jozefiak, Thomas; Sund, Anne Mari; Holen, Solveig; Neumer, Simon-Peter; Martinsen, Kristin D.; Rasmussen, Lene Mari P.; Patras, Joshua; Lydersen, Stian (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-27)
    Background - Prevention is essential to reduce the development of symptomology among children and adolescents into disorders, thereby improving public health and reducing costs. Therefore, easily administered screening and early assessment methods with good reliability and validity are necessary to effectively identify children’s functioning and how these develop. The Brief Problem Monitor (BPM) is ...
  • Tocilizumab increases citrullinated histone 3 in non-ST segment elevation myocardial infarction 

    Helseth, Ragnhild; Kleveland, Ola; Ueland, Thor; Wiseth, Rune; Damås, Jan Kristian; Broch, Kaspar; Michelsen, Annika Elisabet; Bendz, Bjørn; Gullestad, Lars; Aukrust, Pål; Seljeflot, Ingebjørg (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-10)
    Objective: Beyond reducing inflammation and troponin T (TnT) release, the interleukin-6 receptor antagonist tocilizumab reduces neutrophil counts in patients with non-ST segment elevation myocardial infarction (NSTEMI). It is unclear if this is related to formation of neutrophil extracellular traps (NETs), carrying inflammatory and thrombotic properties.<p> <p>Methods - In a placebo-controlled ...
  • Trends in Disability-Free Life Expectancy (DFLE) from 1995 to 2017 in the older Norwegian population by sex and education: The HUNT Study 

    Storeng, Siri Høivik; Øverland, Simon Nygaard; Skirbekk, Vegard; Hopstock, Laila Arnesdatter; Sund, Erik Reidar; Krokstad, Steinar; Strand, Bjørn Heine (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-28)
    Aim: Understanding whether increasing Life Expectancy (LE) translates to improved health and function among older adults is essential, but results are inconclusive. We aimed to estimate trends in Disability-Free Life Expectancy (DFLE) in the older Norwegian population by sex and education from 1995 to 2017.<p> <p>Method: National life table data were combined with cross-sectional data on functional ...
  • A porcine model of hemodialyzer reactions: roles of complement activation and rinsing back of extracorporeal blood 

    Pethő, Ákos; Piecha, Dorothea; Mészáros, Tamás; Urbanics, Rudolf; Moore, Christoph; Canaud, Bernard; Mollnes, Tom Eirik; Steppan, Sonja; Szénási, Gábor; Szebeni, János; Dézsi, László (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-09)
    Hemodialysis reactions (HDRs) resemble complement-activation-related pseudoallergy (CARPA) to certain i.v. drugs, for which pigs provide a sensitive model. On this basis, to better understand the mechanism of human HDRs, we subjected pigs to hemodialysis using polysulfone (FX CorDiax 40, Fresenius) or cellulose triacetate (SureFlux-15UX, Nipro) dialyzers, or Dialysis exchange-set without membranes, ...
  • Inspiratory crackles-early and late-revisited: identifying COPD by crackle characteristics 

    Melbye, Hasse; Aviles Solis, Juan Carlos; Jacome, Cristina; Pasterkamp, Hans (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-05)
    Background The significance of pulmonary crackles, by their timing during inspiration, was described by Nath and Capel in 1974, with early crackles associated with bronchial obstruction and late crackles with restrictive defects. Crackles are also described as ‘fine’ or ‘coarse’. We aimed to evaluate the usefulness of crackle characteristics in the diagnosis of chronic obstructive pulmonary disease ...
  • Salmon louse infestation levels on sea trout can be predicted from a hydrodynamic lice dispersal model 

    Bøhn, Thomas; Nilsen, Rune; Gjelland, Karl Øystein; Biuw, Martin; Primicerio, Raul; Karlsen, Ørjan; Serra Llinares, Rosa Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-13)
    1. The abundance of the parasitic salmon louse has increased with the growth in aquaculture of salmonids in open net pens. This represents a threat to wild salmonid populations as well as a key limiting factor for salmon farming. The Norwegian ‘traffic light’ management system for salmon farming aims to increase aquaculture production while securing sustainable wild salmonid populations. However, ...
  • Zinc-Chelating Compounds as Inhibitors of Human and Bacterial Zinc Metalloproteases 

    Rahman, Fatema; Wushur, Imin; Malla, Nabin; Åstrand, Ove Alexander Høgmoen; Rongved, Pål; Winberg, Jan-Olof; Sylte, Ingebrigt (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-22)
    Inhibition of bacterial virulence is believed to be a new treatment option for bacterial infections. In the present study, we tested dipicolylamine (DPA), tripicolylamine (TPA), tris pyridine ethylene diamine (TPED), pyridine and thiophene derivatives as putative inhibitors of the bacterial virulence factors thermolysin (TLN), pseudolysin (PLN) and aureolysin (ALN) and the human zinc metalloproteases, ...
  • Dysleksi: Tidlige risikomarkører for dysleksi 

    Riise, Sølvi Grønning (Master thesis; Mastergradsoppgave, 2021-12-15)
    The purpose of this master's thesis was to investigate whether or not students who were identified with poor literacy skills at 3rd grade, displayed poor literacy skills at the start of 1st grade and in 2nd grade. The theoretical framework for the master's thesis is the prevailing etiological model for dyslexia, namely the Multiple Deficit Model (MDM). It suggests that dyslexia (and other developmental ...
  • Management of patients with metastatic renal cell cancer and bone metastases 

    Nieder, Carsten; Dalhaug, Astrid; Pawinski, Adam (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-28)
    Background/Aim: Previous research has suggested that patients with metastatic renal cell cancer (mRCC) and bone metastases have a poorer prognosis compared to their counterparts with no skeletal involvement. Therefore, we analyzed the management and outcomes of such patients in our center. Patients and Methods: We performed a retrospective study of 35 consecutive patients who received systemic ...
  • On the Use of Time Series Kernel and Dimensionality Reduction to Identify the Acquisition of Antimicrobial Multidrug Resistance in the Intensive Care Unit 

    Escudero-Arnanz, Oscar; Rodríguez-Álvarez, Joaquín; Mikalsen, Karl Øyvind; Jenssen, Robert; Soguero-Ruiz, Cristina (Conference object; Konferansebidrag, 2021)
    The acquisition of Antimicrobial Multidrug Resistance (AMR) in patients admitted to the Intensive Care Units (ICU) is a major global concern. This study analyses data in the form of multivariate time series (MTS) from 3476 patients recorded at the ICU of University Hospital of Fuenlabrada (Madrid) from 2004 to 2020. 18% of the patients acquired AMR during their stay in the ICU. The goal of ...

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