Recent additions

  • Are the Relationships of Lean Mass and Fat Mass With Bone Microarchitecture Causal or Due to Familial Confounders? A Novel Study of Adult Female Twin Pairs 

    Bui, Minh; Zebaze, Roger; Li, Shuai; Hopper, John L.; Bjørnerem, Åshild (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-01)
    It is not known whether the relationships of lean mass (LM) and fat mass (FM) with bone microarchitecture and geometry are causal and/or are because of confounders, including familial confounders arising from genetic and environment effects shared by relatives. We tested the hypotheses that: (i) LM is associated with cortical bone traits, (ii) FM is associated with trabecular bone traits, and (iii) ...
  • Evaluating a centralised cancer support centre in the remote region of Northern Norway 

    Ervik, Bente; Andersen, Sigve; Skirbekk, Helge; Dønnem, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-20)
    Introduction: Being diagnosed with cancer and undergoing treatment is a life-changing experience, and many cancer patients find the physical, emotional and social effects of the disease to be stressful. This study explores the experiences of cancer patients and their relatives from all parts of Northern Norway visiting the centralised cancer support centre. <p> <p>Methods: In a comprehensive ...
  • Exploring the roles of TRIM27 and TRIM32 in autophagy 

    Garcia Garcia, Juncal (Doctoral thesis; Doktorgradsavhandling, 2021-05-21)
    <p>Tripartite motif family proteins (TRIMs) are a wide family of E3 ligases involved in the control of several cellular processes such as intracellular signaling, innate immunity, transcription, cell cycle regulation and carcinogenesis. In recent years, some members of this family have been found to have a role in autophagy. <p>The central theme of this thesis is the role of two TRIM proteins in ...
  • Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants 

    Rodriguez-Martinez, Andrea; Zhou, Bin; Sophiea, Marisa K.; Bentham, James; Paciorek, Christopher J.; Turilli, Maria L.C.; Andersen, Lars Bo; Anderssen, Sigmund Alfred; Ariansen, Inger Kristine Holtermann; Bjertness, Espen; Bjertness, Marius Bergsmark; Ekelund, Ulf; Graff-Iversen, Sidsel; Grøholt, Else Karin; Haugsgjerd, Teresa Risan; Bergh, Ingunn Holden; Janszky, Imre; Kolle, Elin; Krokstad, Steinar; Madar, Ahmed Ali; Sen, Abhijit; Skodje, Gry Irene; Sørgjerd, Elin Pettersen; Nilsen, Bente; Steene-Johannessen, Jostein; Tarp, Jakob; Tell, Grete S.; Torheim, Liv Elin; Wilsgaard, Tom; Carrillo-Larco, Rodrigo M.; Bennett, James E.; Di Cesare, Mariachiara; Taddei, Cristina; Bixby, Honor; Stevens, Gretchen A.; Riley, Leanne M.; Cowan, Melanie J.; Savin, Stefan; Danaei, Goodarz; Chirita-Emandi, Adela; Kengne, Andre P; Khang, Young-Ho; Laxmaiah, Avula; Malekzadeh, Reza; Miranda, Jaime; Moon, Jin Soo; Popovic, Stevo; Sørensen, Thorkild I.A.; Soric, Maroje; Starc, Gregor (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-07)
    Background - Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents.<p> <p>Methods - For this pooled analysis, we used a database of cardiometabolic ...
  • Choice of immunoassay to evaluate porcine cytokine levels 

    Ueland, Nora Lamark; Ludvigsen, Judith K.; Hellerud, Bernt C; Mollnes, Tom Eirik; Skjeflo, Espen Waage (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-06)
    <i>Background</i> - In order to adequately monitor cytokines in experimental models, currently available methods and commercially available kits should be compared.<br><br> <i>Aim</i> - To compare the plasma and tissue concentrations of IL-1β, IL-6, IL-8, IL-10, and TNF as a measure of systemic inflammation in septic pigs.<br><br> <i>Methods</i> - Cytokines were quantified from blood and tissue ...
  • The role of psychosocial factors and treatment need in dental service use and oral health among adults in Norway 

    Jönsson, Birgitta; Holde, Gro Eirin; Baker, Sarah R. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-11)
    <i>Objectives</i> - This study aimed to explore whether population characteristics were associated with the use of dental services, individual's personal oral health practices, dental caries and oral health‐related impacts using the revised Andersen's behavioural model as the theoretical framework.<br><br> <i>Methods</i> - This cross‐sectional study included participants from a Norwegian general ...
  • Hemodynamic effects of a soluble guanylate cyclase stimulator, Riociguat, and an activator, Cinaciguat, during NO-modulation in healthy pigs 

    Næsheim, Torvind; How, Ole-Jakob; Myrmel, Truls (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-14)
    Cardiovascular diseases are often characterized by dysfunctional endothelium. To compensate for the related lack of nitric oxide (NO), a class of soluble guanylate cyclase (sGC) stimulators and activators have been developed with the purpose of acting downstream of NO in the NO-sGC-cGMP cascade. These drugs have been discovered using photoaffinity labeling of sGC and high-throughput screening of a ...
  • Labour outcomes with defibulation at delivery in immigrant Somali and Sudanese women with type III female genital mutilation/cutting 

    Rouzi, Abdulrahim A.; Berg, Rigmor; Al-Wassia, Heidi; Alamoudi, Rana; Hariri, Wajeh; Sindi, Ghazi; Almansouri, Nisma; Sahly, Nora (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-24)
    INTRODUCTION There is a scarcity of studies on labour outcomes with defibulation. This study assessed the outcomes of labour with defibulation at delivery in women with type III female genital mutilation/cutting (FGM/C) compared to labour without defibulation. METHODS We identified and reviewed the records of all Somali and Sudanese women who delivered at King Abdulaziz University Hospital, ...
  • Yersinia enterocolitica: A Follow-up of the Outbreak in the Norwegian Armed Forces in 2014 

    Borud, Einar Kristian; Håberg, Siri Eldevik; Norheim, Arne Johan; Strand, Leif Åge; Fadum, Elin Anita (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-28)
    Introduction - In the spring of 2014, there was an outbreak of Yersinia enterocolitica (YE) gastroenteritis in four Norwegian military camps—the largest outbreak ever reported in Norway. YE is usually transmitted via food, and the gastrointestinal disease caused by the bacterium is considered a public health problem in several countries. Common symptoms of YE gastroenteritis are abdominal pain, ...
  • Recurrent disease after treatment for cervical intraepithelial neoplasia-The importance of a flawless definition of residual disease and length of follow-up 

    Bjørnerem, Mathilde Seeger; Sørbye, Sveinung; Skjeldestad, Finn Egil (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-09)
    Objective - To evaluate adherence to national guidelines for follow-up, and assess residual and recurrent disease after treatment for cervical intraepithelial neoplasia grade 2 or worse (CIN2+).<p> <p>Study design - In a case-series design women aged 25–69 years treated for primary CIN2+ in 2006–2011 (n = 752) were followed through August 9, 2019 for residual or recurrent disease, i.e., CIN2+ ...
  • Effects of a parent-administered exercise program in the neonatal intensive care unit: Dose does matter-a randomized controlled trial 

    Øberg, Gunn Kristin; Girolami, Gay L; Campell, Suzann K.; Ustad, Tordis; Heuch, Ivar; Jacobsen, Bjarne K.; Kaaresen, Per Ivar; Aulie, Vibeke Smith; Jørgensen, Lone (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-06)
    Background - Despite the risk of delayed motor development in infants born preterm, knowledge about interventions in the neonatal intensive care unitt (NICU) and the effects of dosing is sparse. <p> <p>Objective - The objectives of this study were to examine the effectiveness of a parent-administered exercise program in the NICU on motor outcome at 3 months corrected age (CA) and the effect of ...
  • STudy of Antithrombotic Treatment after IntraCerebral Haemorrhage: Protocol for a randomised controlled trial 

    Larsen, Kristin Tveitan; Forfang, Elisabeth; Pennlert, Johanna; Glader, Eva-Lotta; Kruuse, Christina; Wester, Per; Ihle-Hansen, Hege; Carlsson, Maria; Berge, Eivind; Al-Shahi Salman, Rustam; Wyller, Torgeir Bruun; Rønning, Ole M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-03)
    Background and aims - Many patients with prior intracerebral haemorrhage have indications for antithrombotic treatment with antiplatelet or anticoagulant drugs for prevention of ischaemic events, but it is uncertain whether such treatment is beneficial after intracerebral haemorrhage. STudy of Antithrombotic Treatment after IntraCerebral Haemorrhage will assess (i) the effects of long-term antithrombotic ...
  • The Confidence Database 

    Rahnev, Dobromir; Desender, Kobe; Lee, Alan L. F.; Adler, William T.; Aguilar-Lleyda, David; Akdoğan, Başak; Arbuzova, Polina; Atlas, Lauren Y.; Balcı, Fuat; Bang, Ji Won; Bègue, Indrit; Birney, Damian P.; Brady, Timothy F.; Calder-Travis, Joshua; Chetverikov, Andrey; Clark, Torin K.; Davranche, Karen; Denison, Rachel N.; Dildine, Troy C.; Double, Kit S.; Duyan, Yalçın A.; Faivre, Nathan; Fallow, Kaitlyn; Filevich, Elisa; Gajdos, Thibault; Gallagher, Regan M.; de Gardelle, Vincent; Gherman, Sabina; Haddara, Nadia; Hainguerlot, Marine; Hsu, Tzu-Yu; Hu, Xiao; Iturrate, Iñaki; Jaquiery, Matt; Kantner, Justin; Koculak, Marcin; Konishi, Mahiko; Koß, Christina; Kvam, Peter D.; Kwok, Sze Chai; Lebreton, Maël P.; Lempert, Karolina M.; Ming Lo, Chien; Luo, Liang; Maniscalco, Brian; Martin, Antonio; Massoni, Sébastien; Matthews, Julian; Mazancieux, Audrey; Merfeld, Daniel M.; O’Hora, Denis; Palser, Eleanor R.; Paulewicz, Borysław; Pereira, Michael; Peters, Caroline; Philiastides, Marios G.; Pfuhl, Gerit; Prieto, Fernanda; Rausch, Manuel; Recht, Samuel; Reyes, Gabriel; Rouault, Marion; Sackur, Jérôme; Sadeghi, Saeedeh; Samaha, Jason; Seow, Tricia X. F.; Shekhar, Medha; Sherman, Maxine T.; Siedlecka, Marta; Skóra, Zuzanna; Song, Chen; Soto, David; Sun, Sai; van Boxtel, Jeroen J. A.; Wang, Shuo; Weidemann, Christoph T.; Weindel, Gabriel; Wierzchoń, Michał; Xu, Xinming; Ye, Qun; Yeon, Jiwon; Zou, Futing; Zylberberg, Ariel (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-03)
    Understanding how people rate their confidence is critical for the characterization of a wide range of perceptual, memory, motor and cognitive processes. To enable the continued exploration of these processes, we created a large database of confidence studies spanning a broad set of paradigms, participant populations and fields of study. The data from each study are structured in a common, easy-to-use ...
  • Intestinal inflammatory profile shows increase in a diversity of biomarkers in irritable bowel syndrome 

    Berg, Leif Kyrre; Goll, Rasmus; Fagerli, Erik; Ludviksen, Judith K; Fure, Hilde; Odd Sverre, Moen; Sørbye, Sveinung; Mollnes, Tom Eirik; Florholmen, Jon (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-24)
    Background: It has been proposed that irritable bowel syndrome (IBS) is a low-grade mucosal inflammatory disease. <p> <p>Objective: To characterize the intestinal inflammatory profile in IBS patients with or without fructose intolerance.<p> <p>Design: Patients referred to colonoscopy with IBS complaints were screened for participation. IBS patients diagnosed according to the Rome II criteria ...
  • Tracking of serum 25-hydroxyvitamin D during 21 years 

    Kubiak, Julia Magdalena; Kamycheva, Elena; Jorde, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-11)
    Background/objectives - Our objective was to evaluate the degree of tracking for serum levels of 25-hydroxyvitamin D [25(OH)D] over time, by using data from three previously conducted surveys of the Tromsø study collected in the years 1994/1995 (Tromsø 4), 2007/2008 (Tromsø 6), and 2015/2016 (Tromsø 7).<p> <p>Subjects/methods - Subjects with valid 25(OH)D measurements in all three surveys were ...
  • Provider decision regret - a useful method for analysis of palliative thoracic re-irradiation for lung cancer? 

    Nieder, Carsten; Mannsåker, Bård; Yobuta, Rosalba; Haukland, Ellinor Christin (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-30)
    Background - The overall usefulness of palliative thoracic re-irradiation depends on the balance between efficacy, survival, and toxicity, and is difficult to judge from previous studies. In the absence of patient-reported data, we developed a method for provider decision regret that addresses the question “would we re-irradiate this patient again in light of the known outcome?” Furthermore, we ...
  • Symptom burden in patients with oligometastases at the start of palliative radiotherapy 

    Nieder, Carsten; Kämpe, Thomas A (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-04)
    Background/Aim: Recent studies suggested that patients with oligometastases have a better prognosis compared with those who have widespread dissemination. In both groups, radiotherapy is a commonly applied treatment. Patient-reported symptoms might depend on the burden of disease. Possibly, oligometastatic patients report lower scores for symptoms, such as fatigue or reduced appetite, which tend to ...
  • Long-term survival results after treatment for oligometastatic brain disease 

    Nieder, Carsten; Hintz, Mandy; Popp, Ilinca; Bilger, Angelika; Grosu, Anca L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-04)
    Aim - The aim of this study was to characterize the survival results of patients with up to four brain metastases after intense local therapy (primary surgery or stereotactic radiotherapy) if extracranial metastases were absent or limited to one site, e.g. the lungs.<p> <p>Background - Oligometastatic disease has repeatedly been reported to convey a favorable prognosis.<p> <p>Material and ...
  • Direct angiography demonstrates equal 8-12 years patency rates of radial artery and saphenous vein grafts 

    Bahar, Ramez; Dahl-Eriksen, Øystein; Busund, Rolf; Dahl, Per Erling; Hermansen, Stig Eggen; Iqbal, Amjid; Mannsverk, Jan; Myrmel, Truls; Steigen, Terje; Trovik, Thor; Sørlie, Dag Glen; Bartnes, Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-30)
    Objectives: The benefits of coronary artery bypass surgery depend on lasting graft patency. To aid rational graft selection, the relative long-term merits of radial artery and saphenous vein grafts need to be determined by a gold standard method and with minimal clinically driven selection bias. Methods: The patency rates of various conduits were determined by direct angiography in 76 patients from ...
  • No significant histological or ultrastructural tendinosis changes in the hamstring tendon in patients with mild to moderate osteoarthritis of the knee? 

    Ibrahim, Mustafa; Meknas, Khaled; Steigen, Sonja Eriksson; Olsen, Randi; Sernert, Ninni; Ejerhed, Lars ERik; Kartus, Jüri-Tomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-05)
    Purpose - To investigate the periarticular degenerative changes of the knee joint in association with osteoarthritis (OA). More tendinosis was expected to be found in the semitendinosus tendon in patients with knee OA than in patients without knee OA.<p> <p>Methods - Samples from 41 patients were included between January 2016 and October 2017. Twenty-one patients median age 53 (33–63) years with ...

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