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The Association Between Metabolic Syndrome, Hyperfiltration, and Long-Term GFR Decline in the General Population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-01)Introduction: One-quarter of adults worldwide meet the criteria of metabolic syndrome (MetS). MetS increases the risk of diabetes, chronic kidney disease (CKD), and cardiovascular disease. However, the association between MetS, hyperfiltration, and long-term glomerular filtration rate (GFR) decline in the general population is unknown.<p> <p>Methods: In the Renal Iohexol Clearance Survey (RENIS), ... -
Mercury, silver and selenium in serum before and after removal of amalgam restorations: results from a prospective cohort study in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-16)Objective A prospective cohort study on changes of health complaints after removal of amalgam restorations was carried out at the request of the Norwegian Directorate of Health. The aim was to provide and evaluate experimental treatment to patients with health complaints attributed to dental amalgam fillings. <p><p>Methods Patients (n = 32) with medically unexplained physical symptoms (MUPS), which ... -
Reducing unwarranted variation: can a ‘clinical dashboard’ be helpful for hospital executive boards and top-level leaders?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-23)Background/aim: In the past decades, there has been an increasing focus on defining, identifying and reducing unwarranted variation in clinical practice. There have been several attempts to monitor and reduce unwarranted variation, but the experience so far is that these initiatives have failed to reach their goals. In this article, we present the initial process of developing a safety, quality and ... -
Measuring socioeconomic position in studies of health inequalities
(Doctoral thesis; Doktorgradsavhandling, 2024-02-08)<p>There is a consistent finding that the higher the socioeconomic position (SEP), the better the health. The choice of SEP indicator is crucial in explaining these socioeconomic inequalities. However, a poorly motivated use of SEP indicators prevails in the literature on social health inequalities, hampering the transparency and comparability across studies. Its primary aim is to explore different ... -
Validation of forearm fracture diagnoses in administrative patient registers
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-24)Summary The validity of forearm fracture diagnoses recorded in fve Norwegian hospitals was investigated using image reports and medical records as gold standard. A relatively high completeness and correctness of the diagnoses was found. Algorithms used to define forearm fractures in administrative data should depend on study purpose.<p> <p>Purpose In Norway, forearm fractures are routinely recorded ... -
Association of C-reactive protein with future development of diabetes: A population-based 7-year cohort study among Norwegian adults aged 30 and older in the Tromsø Study 2007-2016
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-29)Objectives The extent to which observed associations between high-sensitivity C-reactive protein (hs-CRP) and incident diabetes are explained by obesity and hypertension remains unclear. This study aimed to investigate the association of hs-CRP with developing diabetes in a Norwegian general population sample.<p> <p>Design A cohort study using two population-based surveys of the Tromsø Study: ... -
The Norwegian registry for spine surgery (NORspine): cohort profile
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-17)Purpose - To review and describe the development, methods and cohort of the lumbosacral part of the Norwegian registry for spine surgery (NORspine).<p> <p>Methods - NORspine was established in 2007. It is government funded, covers all providers and captures consecutive cases undergoing operations for degenerative disorders. Patients’ participation is voluntary and requires informed consent. A set ... -
Associations of inner retinal layers with risk of incident dementia: An individual participant data analysis of four prospective cohort studies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-08)INTRODUCTION - Our main objective was to investigate whether retinal neurodegeneration, estimated from lower thickness of inner retinal layers, was associated with incident all-cause dementia and Alzheimer's disease (AD).<p> <p>METHODS - We performed an individual participant data meta-analysis using unpublished data from four prospective cohort studies with a total of 69,955 participants (n = ... -
Diagnostic accuracy of anti-3-[<sup>18</sup>F]-FACBC PET/MRI in gliomas
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-30)Purpose - The primary aim was to evaluate whether anti-3-[<sup>18</sup>F]FACBC PET combined with conventional MRI correlated better with histomolecular diagnosis (reference standard) than MRI alone in glioma diagnostics. The ability of anti-3-[<sup>18</sup>F]FACBC to differentiate between molecular and histopathological entities in gliomas was also evaluated.<p> <p>Methods - In this prospective ... -
Baseline Demographics, Comorbidities, Treatment Patterns and Burden of Atopic Dermatitis in Adults and Adolescents from the GLOBOSTAD Long-Term Observational Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-06)Introduction - Insights into real-world treatment of atopic dermatitis (AD) are relevant to clinical decision making. The aim of this analysis was to characterize patients who receive dupilumab for AD in a real-world setting.<p> <p>Methods - The GLOBOSTAD registry is an ongoing, longitudinal, prospective, observational study of patients with AD who receive dupilumab according to country-specific ... -
Baroreflex sensitivity following acute upper-body exercise in the cold among stable coronary artery disease patients
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-13)Background: A cold environment and exercise separately affect the autonomic nervous system (ANS), baroreflex sensitivity (BRS), and blood pressure variability (BPV) but their combined effects on post-exercise recovery are not known. Our cross-over trial examined these responses following upper-body static and dynamic exercise performed in a cold and neutral environment in patients with coronary ... -
Prospective randomized clinical studies involving reirradiation: update of a systematic review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-27)Background Reirradiation is a potentially useful option for many patients with recurrent cancer, aiming at cure or symptom palliation, depending on disease/recurrence type and stage. The purpose of this follow-up study to a previous review from 2016 was to summarize all recently published randomized trials. Points of interest again included identifcation of methodological strengths and weaknesses, ... -
Childhood trauma and outcome trajectories in patients with longstanding eating disorders across 17 years
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-27)Background: A large proportion of patients with eating disorders (ED) report experiences of childhood trauma. Latent trajectory analysis in ED samples reveals the complexities in course and outcome and can explore the long-term impact of adverse experiences in childhood.<p> <p>Method: A total of 84 patients with longstanding ED were included. ED symptoms were assessed by the Eating Disorder ... -
Activity-Based Protein Profiling in Methicillin-Resistant Staphylococcus aureus Reveals the Broad Reactivity of a Carmofur-Derived Probe
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-08)Activity-based protein profiling is a powerful chemoproteomic technique to detect active enzymes and identify targets and off-targets of drugs. Here, we report the use of carmofur- and activity-based probes to identify biologically relevant enzymes in the bacterial pathogen Staphylococcus aureus. Carmofur is an anti-neoplastic prodrug of 5-fluorouracil and also has antimicrobial and anti-biofilm ... -
Infection of liver sinusoidal endothelial cells with Muromegalovirus muridbeta1 involves binding to neuropilin-1 and is dynamin-dependent
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-09)Liver sinusoidal endothelial cells (LSEC) are scavenger cells with a remarkably high capacity for clearance of several blood-borne macromolecules and nanoparticles, including some viruses. Endocytosis in LSEC is mainly via the clathrin-coated pit mediated route, which is dynamin-dependent. LSEC can also be a site of infection and latency of betaherpesvirus, but mode of virus entry into these ... -
Liver sinusoidal endothelial cells show reduced scavenger function and downregulation of Fc gamma receptor IIB, yet maintain a preserved fenestration the Glmp gt/gt mouse model of slowly progressing liver fibrosis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-01)Liver sinusoidal endothelial cells (LSECs) are fenestrated endothelial cells with a unique, high endocytic clearance capacity for blood-borne waste macromolecules and colloids. This LSEC scavenger function has been insufficiently characterized in liver disease. The Glmp<sup>gt/gt</sup> mouse lacks expression of a subunit of the MFSD1/GLMP lysosomal membrane protein transporter complex, is born ... -
Comparing associations of handgrip strength and chair stand performance with all-cause mortality—implications for defining probable sarcopenia: the Tromsø Study 2015–2020
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-20)Background Widely adopted criteria suggest using either low handgrip strength or poor chair stand performance to identify probable sarcopenia. However, there are limited direct comparisons of these measures in relation to important clinical endpoints. We aimed to compare associations between these two measures of probable sarcopenia and all-cause mortality. <p><p>Methods Analyses included 7838 ... -
HelseIArbeid – et tiltak for økt mestring og arbeidsdeltakelse? - Kvalitativ del. Følgeforskning på HelseIArbeid – Bedriftstiltaket. En brukerorientert kvalitativ, etnografisk studie fra to arbeidsplasser
(Research report; Forskningsrapport, 2023)<p>Denne rapporten har grunnlag i den kvalitativt orienterte delen av følgeforskningsprosjektet «HelseIArbeid – et tiltak for økt mestring og arbeidsdeltakelse?». HelseIArbeid – bedriftstiltaket er en arbeidshelseintervensjon i regi av NAV og Spesialisthelsetjenesten, som i forskningsperioden ble levert i flere kommuner i Troms og Finnmark. <p>Konseptet HelseIArbeid innebærer en satsing på ... -
Human Exposure to PFAS and Other Anthropogenic Organofluorine Chemicals in Tromsø between 1986 and 2015
(Doctoral thesis; Doktorgradsavhandling, 2023-12-06)Summary In the last century, there has been a dramatic increase in chemical production and number and diversity of chemicals produced. Especially, organofluorine chemistry has increased its importance due to applications in pharmaceuticals, agrochemicals, refrigerant gases and in consumer products and industry with fluoropolymers and per- and polyfluoroalkyl substances (PFAS). PFAS are receiving ... -
Physical activity and survival in chronic comorbidity among adult HIV patients in Ethiopia: a prospective cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-07)Background - Antiretroviral therapy enables people living with HIV to live long lives, and these advances have transformed HIV infection from an acute to a chronic disease. Many non-communicable diseases, including type 2 diabetes, heart disease, and stroke, are influenced by physical inactivity. Therefore, the aim of this study was to assess the level of physical activity and survival in chronic ...
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