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Pathological mechanisms of the ubiquitin E3 ligases TRIM27, TRIM32 and TRIM45 in cancer and autophagy
(Doctoral thesis; Doktorgradsavhandling, 2025-09-26)TRIM proteins are E3 ubiquitin ligases, meaning that they modify other substrate proteins with ubiquitin, either tagging them for destruction or influencing their function. We have focused on three TRIM proteins, TRIM32, TRIM45, and TRIM27. Using in silico and in vitro methods we have further elucidated the importance of TRIM proteins in tumorigenesis and autophagy. In our study we found ... -
Testing the Protein Leverage Hypothesis in a Norwegian Population-Based Sample: The Tromsø Study 2015-2016
(Master thesis, 2025)The protein leverage hypothesis proposes that the obesity epidemic is driven by the essential need to obtain sufficient dietary protein. In diets that contain low levels of protein, a leveraging mechanism will cause overconsumption of foods high in carbohydrate and fat as people attempt to reach their protein target. Ultra-processed foods (UPFs) may be involved in this process as they often contain ... -
The Graduating European Dentist Curriculum Framework: A Multi-Stakeholder View
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-08-14)In 2025 the Association for Dental Education in Europe (ADEE) Graduating European Dentist (GED) taskforce held an international multi-stakeholder event that undertook a deep-dive into the perceived ideologies underpinning Oral Health Professional (OHP) education. This paper reports how the event was planned and conducted—and reports the challenges that were discussed in relation to delivering OHP ... -
Adolescence to Midlife Exercise Trajectories and Age at Natural Menopause: A Population Study of 246 147 Women in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-05-02)Objective - Lifestyle factors influence age at natural menopause, but the role of exercise remains uncertain. We aimed to identify adolescence to midlife exercise trajectories and study the associations of exercise trajectories with age at natural menopause.<p> <p>Design - Retrospective population-based cohort study.<p> <p>Setting - Self-administered questionnaires in the Norwegian breast ... -
Prediagnostic self-rated health and survival in women diagnosed with cancer in the Norwegian Women and Health Study: a prospective cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-08-13)Objectives - Self-rated health (SRH) is a well-established predictor of all-cause mortality. However, its predictive value in patients with cancer remains unclear. We aimed to elucidate the relationship between prediagnostic SRH and mortality among patients with cancer using data from the Norwegian Women and Health (NOWAC) Study.<p> <p>Design - A prospective cohort study.<p> <p>Settings and ... -
How have changes in public funding and accessibility influenced contraceptive use among Norwegian adolescents? A cohort study
(Master thesis; Mastergradsoppgave, 2023-08-17)Introduction - Since the law on the right to self-determined abortion passed in 1978, the Norwegian Government have intensified their work on preventing unintended pregnancies and abortions among adolescents. Some of the measures that have been introduced are the reimbursement scheme for hormonal contraceptives and the authorization of public health nurses and midwives to prescribe hormonal ... -
Perinatal fluoxetine exposure increases male rat sexual behavior
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-08-12)Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed to pregnant women due to their efficacy and safety profile, leading to potential exposure of the developing fetus and infant. Serotonin, which acts as a neurotransmitter in adults and is crucial for regulating male sexual behavior, also serves as a neurotrophic factor during early brain development. Yet, the long-term consequences ... -
Targeting Kinases for (Radio) Pharmaceutical Development
(Doctoral thesis; Doktorgradsavhandling, 2025-09-05)Kinases are a central class of proteins in biological signaling. In many cancers, kinase activity is altered due to mutations, overexpression, or misregulation. This makes kinases highly attractive targets for pharmaceutical and diagnostic development. This thesis explores these two approaches to kinase targeting: (A) the development of small molecule inhibitors for kinases and other oncological ... -
Platelets and Placenta - the New Hotspot of Fetomaternal Crosstalk. Unveiling Placental Implications of Human Platelet Antigen Alloimmunization
(Doctoral thesis; Doktorgradsavhandling, 2025-09-04)Fetal neonatal alloimmune thrombocytopenia (FNAIT) is caused by maternal alloantibodies that target human platelet antigens (HPAs) on fetal platelets, most commonly HPA-1a. Integrin β3, expressing the HPA-1a epitope, however, is also displayed on placental cells. Associations between HPA-1a alloimmunized mothers and low birthweight in addition to reports of chronic placental inflammations in ... -
From Resilience to Resistance: A longitudinal multimodal ethnographic study among young Haitians
(Doctoral thesis; Doktorgradsavhandling, 2025-08-29)This thesis provides an ethnographic exploration of the resilience, agency, and creative strategies of Haitian youth connected to a youth club in Delmas 31–33, Port-au-Prince. The study employs collaborative, multimodal, and sensorial methodologies to interpret embodied and performed expressions. Conducted over six years (2012–2018), the longitudinal approach allowed for the development of trust and ... -
Therapists perspectives on the Early Intervention after Rape study: a qualitative process evaluation of a randomized controlled trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-01-07)Background: Early interventions using trauma-focused cognitive behavioural therapy have the potential to alleviate post-traumatic stress symptoms in individuals who have experienced recent sexual assault. Specialized Sexual Assault Centers (SACs) in Norway offers psychosocial support, however, this support varies across SACs and its efficacy has not been researched. The Early Intervention after Rape ... -
Mammographic density by time and breast: a retrospective cohort study from BreastScreen Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-05-16)Background - Mammographic density is known to decrease over time in postmenopausal women. Longitudinal changes in mammographic density prior to breast cancer diagnosis have been widely discussed and less density reduction has been observed for breast developing versus not developing cancer. We aimed to verify these findings among participants of BreastScreen Norway.<p> <p>Methods - In this ... -
Inclusion in the cancer patient pathway among cancer patients with and without pre-existing mental or substance use disorders: a nationwide register-based study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-05-29)Background - Cancer patients with a pre-existing mental disorder or substance use disorder (SUD) have a poorer prognosis compared to other cancer patients, with suboptimal routes to diagnosis and treatment as possible contributing factors. Shorter intervals from suspicion of cancer to start of cancer treatment have been observed following the implementation of Cancer Patient Pathways (CPP) in the ... -
Retrospective evaluation of a CE-marked AI system, including 1,017,208 mammography screening examinations
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-03-26)Objectives - To retrospectively evaluate the performance of a CE-marked AI system for identifying breast cancer on screening mammograms. Evidence from large retrospective studies is crucial for planning prospective studies and to further ensure safe implementation.<p> <p>Materials and methods - We used data from screening examinations performed from 2004 to 2021 at ten breast centers in BreastScreen ... -
Health researchers’ voluntary science-communication with non-academics: motivations, barriers, and practices
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-05-09)Introduction: This study investigates the motivations, practices, and barriers encountered by health researchers in Norway when engaging in science communication with non-academic audiences. Given the legal mandate for public science communication in Nordic universities, understanding these dynamics is crucial for enhancing the quality and impact of research dissemination.<p> <p>Methods: The ... -
Helserelatert livskvalitet etter hjerteinfarkt
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-03-20)Bakgrunn - Norsk hjerteinfarktregister innhenter pasientrapporterte data om helserelatert livskvalitet tre måneder etter utskriving fra sykehus. Formålet med studien var å sammenligne helserelatert livskvalitet hos pasienter som har hatt hjerteinfarkt med en tilfeldig utvalgt norsk normpopulasjon.<p> <p>Materiale og metode - Pasienter registrert i Norsk hjerteinfarktregister i 2020–23 og en ... -
Prospective evaluation of 92 protein biomarkers for early detection of endometrial cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-04-03)The human epididymis protein 4 (HE4) remains the best available endometrial cancer (EC) biomarker; however, its discrimination between cases and cancer-free individuals is limited and might be improved when combined with other protein markers. We evaluated the discrimination capacity of 92 proteins as potential early detection biomarkers for EC in nested case–control studies in the European Prospective ... -
Safeguarding satisfactory anaesthetic practice - a cross-sectional study of anaesthetic personnel’s experiences and perspectives in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-07-17)Background: Globally, anesthesiologists and nurse anesthetists collaborate closely during anesthesia administration. However, there is a scarcity of guidelines detailing the division of tasks and responsibilities between these two professions. The Norwegian Standard for the Safe Practice of Anesthesia (NSA) was developed jointly by the Norwegian Association of Anesthesiologists and the Norwegian ... -
Development and validation of a risk prediction model for premenopausal breast cancer in 19 cohorts
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-05-01)Background - Incidence of premenopausal breast cancer (BC) has risen in recent years, though most existing BC prediction models are not generalizable to young women due to underrepresentation of this age group in model development.<p> <p>Methods - Using questionnaire-based data from 19 prospective studies harmonized within the Premenopausal Breast Cancer Collaborative Group (PBCCG), representing ... -
Re-attendance to mammographic screening after a false positive screening result
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-04-10)Objective - Attendance as well as re-attendance is important for an effective screening program for breast cancer. We aimed to evaluate re-attendance among women with a false positive versus negative screening result in BreastScreen Norway.<p> <p>Methods - The study sample included 3,990,388 screening examinations performed between 1996 and 2021 among women with an invitation to the subsequent ...
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