Recent additions

  • The chemotherapeutic drug methotrexate selects for antibiotic resistance 

    Gudmundsdottir, Jonina; Fredheim, Elizabeth G. Aarag; Koumans, Catharina I.M.; Hegstad, Joachim; Tang, Po-Cheng; Andersson, Dan I.; Samuelsen, Ørjan; Johnsen, Pål Jarle (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-11)
    Background: Understanding drivers of antibiotic resistance evolution is fundamental for designing optimal treatment strategies and interventions to reduce the spread of antibiotic resistance. Various cytotoxic drugs used in cancer chemotherapy have antibacterial properties, but how bacterial populations are affected by these selective pressures is unknown. Here we test the hypothesis that the widely ...
  • Identification of Endothelial Proteins in Plasma Associated With Cardiovascular Risk Factors 

    Butler, Lynn; Iglesias, Maria J.; Kruse, Larissa D.; Sanchez-Rivera, Laura; Enge, Linnea; Dusart, Philip; Hong, Mun-Gwan; Uhlén, Mathias; Renné, Thomas; Schwenk, Jochen M.; Bergstrom, Göran; Odeberg, Jacob (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-28)
    <b>Objective:</b> Endothelial cell (EC) dysfunction is a well-established response to cardiovascular disease risk factors, such as smoking and obesity. Risk factor exposure can modify EC signaling and behavior, leading to arterial and venous disease development. Here, we aimed to identify biomarker panels for the assessment of EC dysfunction, which could be useful for risk stratification or to monitor ...
  • Covid-19 transmission in fitness centers in Norway - a randomized trial 

    Helsingen, Lise Mørkved; Løberg, Magnus; Refsum, Erle; Gjøstein, Dagrun Kyte; Wieszczy, Paulina; Olsvik, Ørjan; Juul, Frederik Emil; Barua, Ishita; Jodal, Henriette C.; Herfindal, Magnhild; Mori, Yuichi; Jore, Solveig; Lund-Johansen, Fridtjof; Fretheim, Atle; Bretthauer, Michael; Kalager, Mette (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-16)
    Background: Closed fitness centers during the Covid-19 pandemic may negatively impact health and wellbeing. We assessed whether training at fitness centers increases the risk of SARS-CoV-2 virus infection.<p> <p>Methods: In a two-group parallel randomized controlled trial, fitness center members aged 18 to 64 without Covid-19-relevant comorbidities, were randomized to access to training at a ...
  • Development of quantitative assay for simultaneous measurement of purine metabolites and creatinine in biobanked urine by liquid chromatography-tandem mass spectrometry 

    Svistounov, Dmitri; Solbu, Marit Dahl; Jenssen, Trond Geir; Mathisen, Ulla Dorte; Hansen, Terkel; Elgstøen, Katja Benedikte Prestø; Zykova, Svetlana (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-20)
    Purine metabolism is essential for all known living creatures, including humans in whom elevated serum concentration of purine break-down product uric acid (UA) is probably an independent risk factor for mortality, type 2 diabetes and cardiovascular events. An automated multiplex assay that measures several purine metabolites could therefore prove useful in many areas of medical, veterinary and ...
  • Radiofrequency Microtenotomy or Physical Therapy for Achilles Tendinopathy: Results of a Randomized Clinical Trial 

    Al-Ani, Zeiad; Meknas, Dana; Kartus, Jüri-Tomas; Lyngedal, Øyvind; Meknas, Khaled (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-20)
    Background: Achilles tendinopathy is a painful disorder, and various treatment options are available. Bipolar radiofrequency microtenotomy (RFM) has shown promising results in treating tendinosis.<p> <p>Purpose/Hypothesis: The purpose was to compare the results between treatment with bipolar RFM and physical therapy (PT) for patients with midportion Achilles tendinopathy. It was hypothesized that ...
  • Radiofrequency Microtenotomy or Physical Therapy for Achilles Tendinopathy 

    Al-Ani, Zeiad; Meknas, Dana; Juri-Toomas, Kartus; Lyngedal, Øyvind; Meknas, Khaled (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-20)
    Background: Achilles tendinopathy is a painful disorder, and various treatment options are available. Bipolar radiofrequency microtenotomy (RFM) has shown promising results in treating tendinosis.<p> <p>Purpose/Hypothesis: The purpose was to compare the results between treatment with bipolar RFM and physical therapy (PT) for patients with midportion Achilles tendinopathy. It was hypothesized that ...
  • Plasma procoagulant phospholipid clotting time and venous thromboembolism risk 

    Ramberg, Cathrine; Wilsgård, line; Latysheva, Nadezhda; Brækkan, Sigrid Kufaas; Hindberg, Kristian; Sovershaev, Timofey; Snir, Omri; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-20)
    Background - Negatively charged procoagulant phospholipids, phosphatidylserine (PS) in particular, are vital to coagulation and expressed on the surface membrane of extracellular vesicles. No previous study has investigated the association between plasma procoagulant phospholipid clotting time (PPL<sub>CT</sub>) and future risk of venous thromboembolism (VTE).<p> <p>Objectives - To investigate the ...
  • Bacterial genomic epidemiology with mixed samples 

    Mäklin, Tommi; Kallonen, Teemu; Alanko, Jarno; Samuelsen, Ørjan; Hegstad, Kristin; Mäkinen, Veli; Corander, Jukka; Heinz, Eva; Honkela, Antti (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-15)
    Genomic epidemiology is a tool for tracing transmission of pathogens based on whole-genome sequencing. We introduce the mGEMS pipeline for genomic epidemiology with plate sweeps representing mixed samples of a target pathogen, opening the possibility to sequence all colonies on selective plates with a single DNA extraction and sequencing step. The pipeline includes the novel mGEMS read binner for ...
  • GABAA subunit single nucleotide polymorphisms show sex-specific association to alcohol consumption and mental distress in a Norwegian population-based sample 

    Moe, Jenny Skumsnes; Bolstad, Ingeborg; Mørland, Jørg Gustav; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-14)
    Little is known about genetic influences on the relationship between alcohol consumption and mental distress in the general population, where the majority report consumption and distress far below diagnostic thresholds. This study investigated single nucleotide polymorphisms (SNPs) from candidate gene studies on alcohol use disorder and depressive disorders, for association with alcohol consumption ...
  • Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants 

    Tell, Grethe S.; Haugsgjerd, Teresa Risan; Andersen, Lars Bo; Anderssen, Sigmund Alfred; Ariansen, Inger; Bjertness, Espen; Bjertness, Marius Bergsmark; Ekelund, Ulf; Graff Iversen, Sidsel; Kolle, Elin; Krokstad, Steinar; Madar, Ahmed Ali; Mathiesen, Ellisiv B.; MEYER, H.E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-24)
    Background - Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories.<p> <p>Methods - We used data from 1990 to 2019 on people aged 30–79 years from population-representative ...
  • Preventable fractions of cancer incidence attributable to 7-years weight gain in the Norwegian Women and Cancer (NOWAC) study 

    da Silva, Marisa Eleonor; Laaksonen, Maarit A.; Lissner, Lauren; Weiderpass, Elisabete; Rylander, Charlotta (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-15)
    There is a lack of tangible measures for directed public health action to halt the increase in weight and cancer. We estimated the fraction and preventable cases of all and major body fatness-related cancers attributable to 7-years weight gain (≥ 2 kg). We assessed validated self-reported anthropometrics from 44,114 women aged 34–49 years at the enrolment in 1991–1992 and from a second questionnaire ...
  • Vaccine Induced Immune Thrombotic Thrombocytopenia Causing a Severe Form of Cerebral Venous Thrombosis With High Fatality Rate: A Case Series 

    Wiedmann, Markus; Skattør, Thor Håkon; Stray-Pedersen, Arne; Romundstad, Luis Georg; Antal, Ellen-Ann; Marthinsen, Pål Bache; Sørvoll, Ingvild Hausberg; Ernstsen, Siw Leiknes; Lund, Christian G.; Holme, Pål Andre; Johansen, Tonje Okkenhaug; Brunborg, Cathrine; Aamodt, Anne Hege; Schultz, Nina Haagenrud; Skagen, Karolina Ryeng; Skjelland, Mona Elisabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-30)
    During a 2-week period, we have encountered five cases presenting with the combination of cerebral venous thrombosis (CVT), intracerebral hemorrhage and thrombocytopenia. A clinical hallmark was the rapid and severe progression of disease in spite of maximum treatment efforts, resulting in fatal outcome in for 4 out of 5 patients. All cases had received ChAdOx1 nCov-19 vaccine 1–2 weeks earlier and ...
  • A rapid, sensitive, and specific assay to measure TF activity based on chromogenic determination of thrombin generation 

    Østerud, Bjarne; Latysheva, Nadezhda; Schoergenhofer, Christian; Jilma, Bernd; Hansen, John-Bjarne; Snir, Omri (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-25)
    Background - Most tissue factor (TF) activity assays are based on measurement of factor X (FX) activation by TF in the presence of factor VII (FVII)/FVIIa. This requires long incubation, which may result in TF-independent activity of FX and inaccurate measurement of TF activity.<p> <p>Aim - To develop a sensitive and specific TF activity assay, which does not register a non-specific TF activity, ...
  • Rosuvastatin treatment decreases plasma procoagulant phospholipid activity after a VTE: A randomized controlled trial 

    Ramberg, Cathrine; Hindberg, Kristian; Biedermann, Joseph S.; Cannegieter, Suzanne C.; van der Meer, Felix J.; Snir, Omri; Leebeek, Frank W. G.; Kruip, Marieke J. H. A.; Hansen, John Bjarne; Lijfering, Willem M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-25)
    Background - Venous thromboembolism (VTE) is a frequent cardiovascular disease with severe complications, including recurrence and death. There is a great need for alternative prophylactic treatment options as anticoagulation is accompanied by increased bleeding risk. Statins are reported to reduce the risk of incident and recurrent VTE, but the mechanisms are elusive. Procoagulant phospholipids ...
  • Drug-eluting or bare-metal stents for left anterior descending or left main coronary artery revascularization 

    Piccolo, Raffaele; Bonaa, Kaare H.; Efthimiou, Orestis; Varenne, Olivier; Urban, Philip; Kaiser, Christoph; Räber, Lorenz; de Belder, Adam; Remkes, Wouter; Van’T Hof, Arnoud W. J.; Stankovic, Goran; Lemos, Pedro A.; Wilsgaard, Tom; Reifart, Jörg; Rodriguez, Alfredo E.; Ribeiro, Expedito E.; Serruys, Patrick W. J. C.; Abizaid, Alex; Sabaté, Manel; Byrne, Robert A.; de la Torre Hernandez, Jose M.; Wijns, William; Esposito, Giovanni; Jüni, Peter; Windecker, Stephan; Valgimigli, Marco (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-08)
    Background - New‐generation drug‐eluting stents (DES) reduce target‐vessel revascularization compared with bare‐metal stents (BMS), and recent data suggest that DES have the potential to decrease the risk of myocardial infarction and cardiovascular mortality. We evaluated the treatment effect of DES versus BMS according to the target artery (left anterior descending [LAD] and/or left main [LM] versus ...
  • Obesity does not protect from subarachnoid haemorrhage: Pooled analysis of 3 large prospective Nordic cohorts 

    Rautalin, Ilari; Kaprio, Jaakko; Ingebrigtsen, Tor; Jousilahti, Pekka; Løchen, Maja-Lisa; Romundstad, Pål Richard; Salomaa, Veikko; Vik, Anne; Wilsgaard, Tom; Mathiesen, Ellisiv B.; Sandvei, Marie Søfteland; Korja, Miikka (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-10)
    Background and purpose: Several population-based cohort studies have related higher body mass index (BMI) to a decreased risk of subarachnoid hemorrhage (SAH). The main objective of our study was to investigate whether the previously reported inverse association can be explained by modifying effects of the most important risk factors of SAH—smoking and hypertension.<p> <p>Methods: We conducted ...
  • Biofilm Responsive Zwitterionic Antimicrobial Nanoparticles to Treat Cutaneous Infection 

    Obuobi, Sybil Akua Okyerewa; Phung, Anna Ngoc; Julin, Kjersti; Johannessen, Mona; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-16)
    To avert the poor bioavailability of antibiotics during S. aureus biofilm infections, a series of zwitterionic nanoparticles containing nucleic acid nanostructures were fabricated for the delivery of vancomycin. The nanoparticles were prepared with three main lipids: (i) neutral (soy phosphatidylcholine; P), (ii) positively charged ionizable (1,2-dioleyloxy-3-dimethylaminopropane; D), and (iii) ...
  • Social and life skills in adolescents who have self-harmed: analysis of survey responses from a national sample of adolescents in Norway 

    Fadum, Elin Anita; Carlsen, Ellen Øen; Ramberg, Maria; Strand, Leif Aage; Håberg, Siri Eldevik; Borud, Einar Kristian; Martinussen, Monica (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-12)
    Objective - Social and life skills (SLS) may be important in the prevention and treatment of self-harm, but few studies have described this relationship. We examined three components of SLS in adolescents who reported self-harm that was, according to themselves, diagnosed by a clinician.<p> <p>Design - Cross-sectional.<p> <p>Setting - National screening prior to military service.<p> <p>Participants ...
  • The Infectious Dose Shapes Vibrio Cholerae Within-Host Dynamics 

    Gillman, Aaron Nicholas; Mahmutovic, Anel; Abel zur Wiesch, Pia; Abel, Sören (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-07)
    During infection, the rates of pathogen replication, death, and migration affect disease progression, dissemination, transmission, and resistance evolution. Here, we follow the population dynamics of Vibrio cholerae in a mouse model by labeling individual bacteria with one of >500 unique, fitness-neutral genomic tags. Using the changes in tag frequencies and CFU numbers, we inform a mathematical ...
  • Effect of cements on fracture resistance of monolithic zirconia crowns 

    Nakamura, Keisuke; Mouhat, Mathieu; Nergård, John Magnus; Lægreid, Solveig Jenssen; Kanno, Taro; Milleding, Percy; Ørtengren, Ulf Thore (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-01-26)
    Objectives - The present study investigated the effect of cements on fracture resistance of monolithic zirconia crowns in relation to their compressive strength.<p> <p>Materials and methods - Four different cements were tested: zinc phosphate cement (ZPC), glass-ionomer cement (GIC), self-adhesive resin-based cement (SRC) and resin-based cement (RC). RC was used in both dual cure mode (RC-D) and ...

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