Det helsevitenskapelige fakultet

Recent additions

  • Depressive symptoms and anger and aggression in Russian adolescents 

    Ruchkin, Vladislav; Stickley, Andrew; Koposov, Roman Alexandriovich; Sukhodolsky, D; Isaksson, Johan (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-16)
    Research among adolescents exploring the association between depressive symptoms and aggression has produced inconsistent findings. This study investigated the prevalence of clinically significant (current major depressive episode) and subthreshold depressive symptoms in a general population sample of adolescents from Northern Russia and explored their association with aggression and anger, while ...

  • Behandling av senskader hos kreftpasienter 

    Kristoffersen, Agnete Egilsdatter; Bjelland, Mona (Journal article; Tidsskriftartikkel; Peer reviewed, 2023)
    En ny norsk studie utført av Kreftforeningen og Nasjonalt forskningssenter innen komplementær og alternativ medisin (NAFKAM) har undersøkt omfanget av senskader etter kreft og kreftbehandling i Norge og har kartlagt hvilke alternative behandlingsformer som brukes for å håndtere disse utfordringene.

  • Fatal and non-fatal breast cancers in women targeted by BreastScreen Norway: a cohort study 

    Tsuruda, Kaitlyn; Hoff, Solveig Kristin Roth; Akslen, Lars Andreas; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-04)
    Background - Many breast cancer survivors experience anxiety related to dying from their disease even if it is detected at an early stage. We aimed to increase knowledge about fatal and non-fatal breast cancer by describing how histopathological tumour profiles and detection modes were associated with 10-year breast cancer-specific survival.<p> <p>Methods - This cohort study included data from ...

  • Public health restrictions, directives, and measures in Arctic countries in the first year of the COVID-19 pandemic 

    Peterson, Malory; Akearok, Gwen Healey; Cueva, Katie; Lavoie, Josée G.; Larsen, Christina VL; Jóhannsdóttir, Lára; Cook, David; Nilsson, Lena Maria; Rautio, Arja; Timlin, Ulla; San Sebastián, Miguel; Gladun, Elena; Rink, Elizabeth; Broderstad, Ann Ragnhild; Dagsvold, Inger Johanne; Siri, Susanna Ragnhild Andersdatter; Ottendahl, Charlotte Brandstrup; Olesen, Ingelise; Zatseva, Larisa; Young, Rebecca Ipiaqruk; Chaliak, Ay’aqulluk Jim; Ophus, Emily; Stoor, Jon Petter Anders (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-29)
    Beginning January of 2020, COVID-19 cases detected in Arctic countries triggered government policy responses to stop transmission and limit caseloads beneath levels that would overwhelm existing healthcare systems. This review details the various restrictions, health mandates, and transmission mitigation strategies imposed by governments in eight Arctic countries (the United States, Canada, Greenland, ...

  • Altered biomarkers for cardiovascular disease and inflammation in autoimmune Addison's disease - a cross-sectional study 

    Sævik, Åse Bjorvatn; Ueland, Grethe Åstrøm; Åkerman, Anna-Karin; Methlie, Paal; Quinkler, Marcus; Jørgensen, Anders Palmstrøm; Höybye, Charlotte; Debowska, Aleksandra; Nedrebø, Bjørn Gunnar; Dahle, Anne Lise; Carlsen, Siri; Tomkowicz, Aneta; Sollid, Stina Therese; Nermoen, Ingrid; Grønning, Kaja; Dahlqvist, Per; Grimnes, Guri; Skov, Jakob; Finnes, Trine Elisabeth; Valland, Susanna Fonneland; Wahlberg, Jeanette; Holte, Synnøve Emblem; Kämpe, Olle; Bensing, Sophie; Husebye, Eystein Sverre; Øksnes, Marianne (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-09)
    Objective - Increased prevalence of cardiovascular disease has been reported in autoimmune Addison's disease (AAD), but pathomechanisms are poorly understood.<p> <p<Design - Cross-sectional study.<p> <p>Methods - We compared serum levels of 177 cardiovascular and inflammatory biomarkers in 43 patients with AAD at >18-h glucocorticoid withdrawal and 43 matched controls, overall and stratified ...

  • Physiotherapy as part of collaborative and person-centered rehabilitation services: the social systems constraining an innovative practice 

    Forslund, Lina; Arntzen, Cathrine; Nikolaisen, Morten; Gramstad, Astrid; Eliassen, Marianne (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-07)
    Background: A person-centered and collaborative practice is considered crucial in contemporary physiotherapy. These ideals are often embraced in theory but are difficult to put into practice. As problems and solutions are related, understanding and refining theory on practical problems can close the knowing-doing gap and link the problem to the development of possible solutions.<p> <p>Objective: ...

  • Effectiveness and potential mechanism of Jiawei-Xiaoyao-San for hyperthyroidism: a systematic review 

    Ma, Wenxin; Zhang, Xiaowen; Zhao, Ruotong; Tang, Yang; Zhu, Xiaoyun; Liu, Longkun; Xu, Mingyuan; Wang, Ge; Peng, Peiyue; Liu, Jianping; Liu, Zhaolan (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-13)
    Objectives: To evaluate the effectiveness and potential mechanism of traditional Chinese medicine Jiawei-Xiaoyao-San (JWXYS) as an adjunct or mono- therapy for antithyroid drugs (ATDs) in the treatment of hyperthyroidism.<p> <p>Methods: Eight databases and three trial registries were searched from inception until May 2023. Randomized controlled trials (RCTs) were included and meta-analysis was ...

  • GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification 

    Lagou, Vasiliki; Jiang, Longda; Ulrich, Anna; Zudina, Liudmila; González, Karla Sofia Gutiérrez; Balkhiyarova, Zhanna; Faggian, Alessia; Maina, Jared G.; Chen, Shiqian; Todorov, Petar V.; Sharapov, Sodbo; David, Alessia; Marullo, Letizia; Mägi, Reedik; Rujan, Roxana-Maria; Ahlqvist, Emma; Thorleifsson, Gudmar; Gao, Ηe; Εvangelou, Εvangelos; Benyamin, Beben; Scott, Robert A.; Isaacs, Aaron; Zhao, Jing Hua; Willems, Sara M.; Johnson, Toby; Gieger, Christian; Grallert, Harald; Meisinger, Christa; Müller-Nurasyid, Martina; Strawbridge, Rona J.; Goel, Anuj; Rybin, Denis; Albrecht, Eva; Jackson, Anne U.; Stringham, Heather M.; Corrêa, Ivan R.; Farber-Eger, Eric; Steinthorsdottir, Valgerdur; Uitterlinden, André G.; Munroe, Patricia B.; Brown, Morris J.; Schmidberger, Julian; Holmen, Oddgeir Lingaas; Thorand, Barbara; Hveem, Kristian; Wilsgaard, Tom; Mohlke, Karen L.; Wang, Zhe; Shmeliov, Aleksey; den Hoed, Marcel; Loos, Ruth J. F.; Kratzer, Wolfgang; Haenle, Mark; Koenig, Wolfgang; Boehm, Bernhard O.; Tan, Tricia M.; Tomas, Alejandra; Salem, Victoria; Barroso, Inês; Tuomilehto, Jaakko; Boehnke, Michael; Florez, Jose C.; Hamsten, Anders; Watkins, Hugh; Njølstad, Inger; Wichmann, H.-Erich; Caulfield, Mark J.; Khaw, Kay-Tee; van Duijn, Cornelia M.; Hofman, Albert; Wareham, Nicholas J.; Langenberg, Claudia; Whitfield, John B.; Martin, Nicholas G.; Montgomery, Grant; Scapoli, Chiara; Tzoulaki, Ioanna; Elliott, Paul; Thorsteinsdottir, Unnur; Stefansson, Kari; Brittain, Evan L.; McCarthy, Mark I.; Froguel, Philippe; Sexton, Patrick M.; Wootten, Denise; Groop, Leif; Dupuis, Josée; Meigs, James B.; Deganutti, Giuseppe; Demirkan, Ayse; Pers, Tune H.; Reynolds, Christopher A.; Aulchenko, Yurii S.; Kaakinen, Marika A.; Jones, Ben; Prokopenko, Inga (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-07)
    Conventional measurements of fasting and postprandial blood glucose levels investigated in genome-wide association studies (GWAS) cannot capture the effects of DNA variability on ‘around the clock’ glucoregulatory processes. Here we show that GWAS meta-analysis of glucose measurements under nonstandardized conditions (random glucose (RG)) in 476,326 individuals of diverse ancestries and without ...

  • Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH): prospective, individual participant data meta-analysis of randomised trials 

    Al-Shahi Salman, Rustam; Stephen, Jacqueline; Tierney, Jayne F; Lewis, Steff C; Newby, David E; Parry-Jones, Adrian R; White, Philip M; Connolly, Stuart J; Benavente, Oscar R; Dowlatshahi, Dar; Cordonnier, Charlotte; Viscoli, Catherine M; Sheth, Kevin N; Kamel, Hooman; Veltkamp, Roland; Larsen, Kristin Tveitan; Hofmeijer, Jeannette; Kerkhoff, Henk; Schreuder, Floris H B M; Shoamanesh, Ashkan; Klijn, Catharina J M; van der Worp, H Bart; Song, Lili; Wyller, Torgeir Bruun; Rønning, Ole Morten; Ihle-Hansen, Hege Beathe; Sandset, Else Charlotte; Carlsson, Maria Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-12)
    Background - The safety and efficacy of oral anticoagulation for prevention of major adverse cardiovascular events in people with atrial fibrillation and spontaneous intracranial haemorrhage are uncertain. We planned to estimate the effects of starting versus avoiding oral anticoagulation in people with spontaneous intracranial haemorrhage and atrial fibrillation.<p> <p>Methods - In this prospective ...

  • Prolonged Cardiopulmonary Resuscitation in Accidental Hypothermia: Physiological and pathophysiological effects of cardiopulmonary resuscitation (CPR) in hypothermia regarding hemodynamics, oxygen transport and regional blood flow 

    Valkov, Sergei (Doctoral thesis; Doktorgradsavhandling, 2023-12-21)
    This thesis was aimed to examine the physiological and pathophysiological effects of 3 hours continuous cardiopulmonary resuscitation (CPR) at 27°C concerning hemodynamics, oxygen transport, and regional blood flow. We aimed to explore mechanisms responsible for the successful resuscitation of accidental hypothermia victims in hypothermic cardiac arrest (HCA) and evaluate their value during prolonged ...

  • Recurrent venous thromboembolism and bleeding with extended anticoagulation: the VTE-PREDICT risk score 

    De Winter, Maria A.; Büller, Harry R.; Carrier, Marc; Cohen, Alexander T.; Hansen, John Bjarne; Kaasjager, Karin A. H.; Kakkar, Ajay K.; Middeldorp, Saskia; Raskob, Gary E.; Sørensen, Henrik T.; Visseren, Frank L. J.; Wells, Philip S.; Dorresteijn, Jannick A. N.; Nijkeuter, Mathilde; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-17)
    Aims Deciding to stop or continue anticoagulation for venous thromboembolism (VTE) after initial treatment is challenging, as individual risks of recurrence and bleeding are heterogeneous. The present study aimed to develop and externally validate models for predicting 5-year risks of recurrence and bleeding in patients with VTE without cancer who completed at least 3 months of initial treatment, ...

  • Description of the prehospital emergency healthcare system in Norway 

    Kjærvoll, Hege K.; Andersson, Lars-Jøran; Bakkelund, Karin Elvenes; Harring, Astrid Karina V.; Tjelmeland Myrhaugen, Ingvild Beathe (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-23)
    Background: Norway has a long coastline, steep mountains, and wide fjords, which presents some challenges to the prehospital emergency healthcare system. In recent years, the prehospital emergency medical services (EMS) have undergone significant changes, structurally, in terms of professionalisation of the services and in the education level of the personnel. In this article, we aim to describe ...

  • Suffering while resigning to an unacceptable violation of dignity 

    Hartviksen, Trude Anita; Aspfors, Jessica Marianne; Uhrenfeldt, Lisbeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-22)
    Background: The interaction of health personnel with relatives is linked to the quality of care results in nursing homes. However, there is limited knowledge of how relatives perceive being an integral part of the nursing home context. This secondary analysis has its starting point in an ethical concern about relatives’ experiences in a previous study.<p> <p>Aim: To critically discuss relatives’ ...

  • A window of opportunities: Composing a relational space for living and telling sustainable stories to live by 

    Lyngstad, Mette Bøe; Blix, Bodil Hansen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-22)
    This article is based on experiences with the Dreamcatchers, a project involving people living with substance addiction, and their significant others, in which the participants composed and explored narratives through creative, collaborative processes. In the article, we think with a narrative composed by one of the participants in the project to learn from her experiences. Our thinking is inspired ...

  • The dose-response relationship of pre-menopausal alcohol consumption with age at menopause: a population study of 280 497 women in Norway 

    Langås, Julie Røgler; Eskild, Anne; Hofvind, Solveig Sand-Hanssen; Bjelland, Elisabeth Krefting (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-03)
    Background: Previous research suggests that alcohol consumption is associated with high age at menopause. Yet, knowledge about the dose– response relationship is inconsistent. Thus, we studied the pattern of the association of pre-menopausal alcohol consumption with age at natural menopause.<p> <p>Methods: We performed a retrospective population-based study using self-reported data from 280 497 ...

  • How should tranexamic acid be administered in haemorrhagic shock? - continuous serum concentration measurements in a swine model 

    Lynghaug, Trine; Bakke, Håkon Kvåle; Fuskevåg, Ole Martin; Nielsen, Erik Waage; Dietrichs, Erik Sveberg (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11)
    Background: Tranexamic acid (TXA) reduces mortality in trauma patients. Intramuscular (IM) administration could be advantageous in low-resource and military settings. Achieving the same serum concentration as intravenous (IV) administration is important to achieve equal mortality reduction. Therefore, we aimed to investigate whether dividing an IM dose of TXA between two injection sites and whether ...

  • Evaluation of the One Health-Ness of 20 Years of Antimicrobial Resistance Surveillance in Norway 

    Norström, Madelaine; Simonsen, Gunnar Skov; Slettemeås, Jannice Schau; Furberg, Anne-Sofie; Urdahl, Anne Margrete (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-21)
    We evaluated the One Health-ness (OH-ness) of the surveillance system for antimicrobial resistance (AMR) in Norway by using the recently developed “Evaluation tool for One Health epidemiological surveillance capacities and capabilities” (OH–EpiCap tool). First, we defined the Norwegian AMR surveillance system that we would evaluate. The tool was applied by a group of stakeholders (key persons in the ...

  • Suitability of issuing sickness certificates in remote consultations during the COVID-19 pandemic. A mixed method study of GPs' experiences 

    Breivik, Elin; Kristiansen, Eli; Zanaboni, Paolo; Johansen, Monika Alise; Øyane, Nicolas Melchior Frederic; Bergmo, Trine Strand (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-20)
    Objective - To explore Norwegian GPs’ experiences with and perceived suitability of issuing sickness certifications in remote consultations during the COVID-19 pandemic.<p> <p>Design - We used a mixed methods research design. An online survey with 301 respondents was combined with qualitative interviews with ten GPs.<p> <p>Setting - Norwegian general practice.<p> <p>Results - Most GPs agreed ...

  • Stressful life events and resilience in individuals with and without a history of eating disorders: a latent class analysis 

    Lie, Selma; Wisting, Line Norøm; Stedal, Kristin; Rø, Øyvind; Friborg, Oddgeir (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-16)
    Background - Eating disorders (EDs) are associated with a range of stressful life events, but few have investigated protective factors that may affect these associations. The current study used mixture modelling to describe typologies in life stress exposure and availability of protective resources in individuals with and without eating disorders (EDs).<p> <p>Methods - A case – control sample ...

  • Trajectories of body mass index in adulthood and risk of subtypes of postmenopausal breast cancer 

    Busund, Marit Katinka; Ursin, Giske; Lund, Eiliv; Wilsgaard, Tom; Rylander, Karin Charlotta Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-28)
    Background - Body fatness is a dynamic exposure throughout life. To provide more insight into the association between body mass index (BMI) and postmenopausal breast cancer, we aimed to examine the age at onset, duration, intensity, and trajectories of body fatness in adulthood in relation to risk of breast cancer subtypes.<p> <p>Methods - Based on self-reported anthropometry in the prospective ...

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