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Epidemiology and natural history of POLG disease in Norway: a nationwide cohort study
(Journal article; Tidsskriftartikkel, 2024-06-07)<p><i>Objective</i> To investigate the prevalence and natural history of POLG disease in the Norwegian population. <p><i>Methods</i> A national, population-based, retrospective study using demographic, clinical, and genetic data of patients with genetically confirmed POLG disease. The patients were diagnosed between 2002 and 2022, and were included into the Norwegian POLG Patient Registry. Patients ... -
Co-creating a continuous leadership development program in rural municipal healthcare – an action research study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-22)Background An increasingly complex healthcare system entails an urgent need for competent and resilient leadership. However, there is a lack of extensive research on leadership development within healthcare. The knowledge gaps extend to various frameworks and contexts, particularly concerning municipal healthcare, knowledge leadership, and the application of knowledge in the field of practice. ... -
Use of locums in the Regular GP Scheme 2016–22
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-29)Bakgrunn I fastlegeordningen er det nødvendig å bruke vikarleger når fastleger har fravær eller pasientlister står uten fast lege. Vi har undersøkt forekomst og utvikling av registrerte vikaravtaler i fastlegeordningen i perioden 1.1.2016–31.12.2022.<p> <p>Materiale og metode I denne deskriptive registerstudien kategoriserte vi 21 418 vikaravtaler fra tidsrommet 1.1.2016–31.12.2022 etter ... -
Primary Retroperitoneal Lymph Node Dissection as Treatment for Low-volume Metastatic Seminoma in a Population-based Cohort: The Swedish Norwegian Testicular Cancer Group Experience
(Journal article; Tidsskriftartikkel, 2024-06-11)<p><i>Background and objective</i> There is an unmet need to avoid long-term morbidity associated with standard cytotoxic treatment for low-volume metastatic seminoma. Our aim was to assess the oncological efficacy and surgical safety of retroperitoneal lymph node dissection (RPLND) as treatment in a population-based cohort of metastatic seminoma patients with limited retroperitoneal lymphadenopat ... -
Deciphering Staphylococcus aureus–host dynamics using dual activity-based protein profiling of ATP-interacting proteins
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-24)The utilization of ATP within cells plays a fundamental role in cellular processes that are essential for the regulation of host–pathogen dynamics and the subsequent immune response. This study focuses on ATP-binding proteins to dissect the complex interplay between Staphylococcus aureus and human cells, particularly macrophages (THP-1) and keratinocytes (HaCaT), during an intracellular infection. ... -
Body weight and composition endpoints in cancer cachexia clinical trials: Systematic Review 4 of the cachexia endpoints series
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-13)Significant variation exists in the outcomes used in cancer cachexia trials, including measures of body composition, which are often selected as primary or secondary endpoints. To date, there has been no review of the most commonly selected measures or their potential sensitivity to detect changes resulting from the interventions being examined. The aim of this systematic review is to assess the ... -
Targeted temperature control following traumatic brain injury: ESICM/NACCS best practice consensus recommendations
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-20)Aims and scope The aim of this panel was to develop consensus recommendations on targeted temperature control (TTC) in patients with severe traumatic brain injury (TBI) and in patients with moderate TBI who deteriorate and require admission to the intensive care unit for intracranial pressure (ICP) management.<p> <p>Methods A group of 18 international neuro-intensive care experts in the acute ... -
Biomarker endpoints in cancer cachexia clinical trials: Systematic Review 5 of the cachexia endpoint series
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-23)Regulatory agencies require evidence that endpoints correlate with clinical benefit before they can be used to approve drugs. Biomarkers are often considered surrogate endpoints. In cancer cachexia trials, the measurement of biomarkers features frequently. The aim of this systematic review was to assess the frequency and diversity of biomarker endpoints in cancer cachexia trials. A comprehensive ... -
Impact of Prosigna test on adjuvant treatment decision in lymph node-negative early breast cancer—a prospective national multicentre study (EMIT-1)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-04)Background: EMIT-1 is a national, observational, single-arm trial designed to assess the value of the Prosigna, Prediction Analysis of Microarray using the 50 gene classifier (PAM50)/Risk of Recurrence (ROR), test as a routine diagnostic tool, examining its impact on adjuvant treatment decisions, clinical outcomes, side-effects and cost-effectiveness. Here we present the impact on treatment ... -
Child-Inclusive Mandatory Family Mediation in Norway: A sociocultural exploration of children’s participation
(Doctoral thesis; Doktorgradsavhandling, 2024-10-11)<p><i>Introduction:</i> Family mediation should help separating parents make agreements that attend to the best interest of the child. Children can be included in this process. The aim of this dissertation is to explore the practise of child-inclusive family mediation in Norway on three interdependent planes: a personal, an interpersonal, and a cultural and institutional plane. These planes follow ... -
Survival after docetaxel for metastatic castration-resistant prostate cancer in a rural health care setting
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-15)Introduction: The aim of this study was to evaluate overall survival of men who received systemic therapy with docetaxel for metastatic castrationresistant prostate cancer (MCRPC) in rural Nordland County, Norway. Prognostic factors related to treatment and other variables were evaluated.<p> <p>Material and methods: Overall, 132 pa tients were included in this retrospective study covering the ... -
Healthy lifestyle change and all-cause and cancer mortality in the European Prospective Investigation into Cancer and Nutrition cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-29)Background Healthy lifestyles are inversely associated with the risk of noncommunicable diseases, which are leading causes of death. However, few studies have used longitudinal data to assess the impact of changing lifestyle behaviours on all-cause and cancer mortality.<p> <p>Methods Within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, lifestyle profiles of 308,497 ... -
“I felt like a little kind of jolt of energy in my chest”: embodiment in learning in continuing professional development for general practitioners
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-29)Learning in medical education encompasses a broad spectrum of learning theories, and an embodiment perspective has recently begun to emerge in continuing professional development (CPD) for health professionals. However, empirical research into the experience of embodiment in learning in CPD is sparse, particularly in the practice of general medicine. In this study, we aimed to explore general ... -
Dietitians' experiences of nutrition assessment via TeleNutrition: “Video-calls are better than phone-calls, but it's probably difficult for patients to show their ankles on the screen”
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-27)Background & Aims: Nutrition assessment is integral to dietetic practice. TeleNutrition enabled dietitians to continue nutrition care provision during the COVID-19 pandemic but created challenges with undertaking nutrition assessment. The aim of the present study was to describe how dietitians in three Nordic countries perceived their nutrition assessment practice when physically distant from ... -
Depressive Symptoms Are Not Associated with Predementia Cerebrospinal Fluid Amyloid Pathology
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-10)Introduction: Depressive symptoms are associated with Alzheimer’s disease (AD), but their neurobiological and neuropsychological correlates remain poorly understood. We investigate if depressive symptoms are associated with amyloid (Aβ) pathology and cognition in predementia AD.<p><p> Methods: We included subjective cognitive decline (SCD, n = 160) and mild cognitive impairment (MCI, n = 192) from ... -
The association between emotional abuse in childhood and healthcare utilization in adulthood among sami and non-sami: the SAMINOR 2 questionnaire survey
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-21)Background Emotional abuse in childhood is the most common type of childhood abuse worldwide and is associated with a variety of somatic and mental health issues. However, globally and in indigenous contexts, research on the associations between emotional abuse in childhood and somatic and mental specialist healthcare utilization in adulthood is sparse.<p> <p>Aim The main aim of this study ... -
“Using network analysis modularity to group health code systems and decrease dimensionality in machine learning models”
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-11)Background: Machine learning (ML) prediction models in healthcare and pharmacy-related research face challenges with encoding high-dimensional Healthcare Coding Systems (HCSs) such as ICD, ATC, and DRG codes, given the trade-off between reducing model dimensionality and minimizing information loss. Objectives: To investigate using Network Analysis modularity as a method to group HCSs to improve ... -
Måleegenskaper ved den norske versjonen av Parenting Stress Index (PSI), 2. utgave
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-22)Beskrivelse Parenting Stress Index (PSI) er et kartleggingsverktøy for å måle foreldrestress i foreldre-barnrelasjonen, og er tilgjengelig både i fullversjon og kortversjon. Måleinstrumentet ble utviklet av Richard R. Abidin i 1995, og oversatt til norsk av John A. Rønning i 2006. PSI-fullversjon består av et barnedomene på seks delskalaer og et foreldredomene på syv delskalaer som til sammen ... -
Breaking down barriers to mental healthcare access in prison: a qualitative interview study with incarcerated males in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-17)Background Mental health problems are highly prevalent in prison populations. Incarcerated persons generally come from disadvantaged backgrounds and are living under extraordinary conditions while in prison. Their healthcare needs are complex compared to the general population. Studies have found that incarcerated individuals are reluctant to seek help and that they experience challenges in ... -
DNA methylation fine-tunes pro-and anti-inflammatory signalling pathways in inactive ulcerative colitis tissue biopsies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-21)DNA methylation has been implied to play a role in the immune dysfunction associated with inflammatory bowel disease (IBD) and the disease development of ulcerative colitis (UC). Changes of the DNA methylation and correlated gene expression in patient samples with inactive UC might reveal possible regulatory features important for further treatment options for UC. Targeted bisulfite sequencing ...
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